|
Texaphyrin
Texaphyrin is a sub-class of heterocyclic macrocycle molecules known as porphyrins. The molecule was invented by University of Texas at Austin professor Jonathan Sessler. The name texaphryin arose because some of the molecules have a shape that can superimpose onto the points of the star featured on the state flag of Texas. Texaphyrins were nominated as the "State Molecule of Texas", but the buckyball was chosen instead. Sessler has described possible medicinal uses of these compounds in the ''Proceedings of the National Academy of Sciences'' and other scientific journals. Pharmacyclics, Inc., a publicly traded company begun by Sessler, licensed the technology behind texaphyrins from the university to develop commercial and medical uses for the molecules. Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc. It is a photosensitiser for use in photodynamic therapy to treat skin conditions and Prostate cancer Prostate cancer is cancer of the prostat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photodynamic Therapy
Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. It also treats malignant cancers including head and neck, lung, bladder and particular skin. The technology has also been tested for treatment of prostate cancer, both in a dog model and in human prostate cancer patients. It is recognised as a treatment strategy that is both minimally invasive and minimally toxic. Other light-based and laser therapies such as laser wound healing and rejuvenation, or intense pulsed light hair removal do not require a photosensitizer. Photosensitisers have been employed to sterilise blood plasma and wate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jonathan Sessler
Jonathan Sessler (born 20 May 1956 in Urbana, Illinois) is a professor of chemistry at The University of Texas at Austin. He is notable for his pioneering work on expanded porphyrins and their applications to biology and medicine. He is a co-founder of Pharmacyclics, Inc., a company that works with expanded porphyrins, and Anionics, Inc., which develops anion recognition chemistry. Pharmacyclics was sold to AbbVie for $21 billion in 2015. History and career Sessler received his Bachelor of Science in Chemistry in 1977 from the University of California, Berkeley and his Ph.D. in chemistry in 1982 from Stanford University. He continued as a post-doctoral fellow at L'Université Louis Pasteur, and worked in Kyoto, Japan before becoming an Assistant Professor of Chemistry at The University of Texas at Austin in 1984. He was treated for cancer at Stanford University Medical Center during work on his Ph.D. Discussions with his colleagues regarding possible treatments eventual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Texaphyrin
Texaphyrin is a sub-class of heterocyclic macrocycle molecules known as porphyrins. The molecule was invented by University of Texas at Austin professor Jonathan Sessler. The name texaphryin arose because some of the molecules have a shape that can superimpose onto the points of the star featured on the state flag of Texas. Texaphyrins were nominated as the "State Molecule of Texas", but the buckyball was chosen instead. Sessler has described possible medicinal uses of these compounds in the ''Proceedings of the National Academy of Sciences'' and other scientific journals. Pharmacyclics, Inc., a publicly traded company begun by Sessler, licensed the technology behind texaphyrins from the university to develop commercial and medical uses for the molecules. Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc. It is a photosensitiser for use in photodynamic therapy to treat skin conditions and Prostate cancer Prostate cancer is cancer of the prostat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motexafin Lutetium
Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc. It is a photosensitiser for use in photodynamic therapy to treat skin conditions and superficial cancers. It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries). It is photoactivated by 732 nm light which allows greater depth of penetration. Clinical trials Phase II clinical trials were in progress in 1999. A phase I trial for prostate cancer Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gland in the male reproductive system that su ... reported in 2009. References Tetrapyrroles Lutetium complexes {{dermatologic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrocycle
Macrocycles are often described as molecules and ions containing a ring of twelve or more atoms. Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature area of chemistry. Synthesis The formation of macrocycles by ring-closure is called macrocylization. Pioneering work was reported for studies on terpenoid macrocycles. The central challenge to macrocyclization is that ring-closing reactions do not favor the formation of large rings. Instead, small rings or polymers tend to form. This kinetic problem can be addressed by using high-dilution reactions, whereby intramolecular processes are favored relative to polymerizations. Some macrocyclizations are favored using template reactions. Templates are ions, molecules, surfaces etc. that bind and pre-organize compounds, guiding them toward formation of a particular ring size. The crown ethers are often generated in the presence of an alkali metal cation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecule
A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and biochemistry, the distinction from ions is dropped and ''molecule'' is often used when referring to polyatomic ions. A molecule may be homonuclear, that is, it consists of atoms of one chemical element, e.g. two atoms in the oxygen molecule (O2); or it may be heteronuclear, a chemical compound composed of more than one element, e.g. water (molecule), water (two hydrogen atoms and one oxygen atom; H2O). In the kinetic theory of gases, the term ''molecule'' is often used for any gaseous particle regardless of its composition. This relaxes the requirement that a molecule contains two or more atoms, since the noble gases are individual atoms. Atoms and complexes connected by non-covalent interactions, such as hydrogen bonds or ionic bonds, are typic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Porphyrin
Porphyrins ( ) are a group of heterocyclic macrocycle organic compounds, composed of four modified pyrrole subunits interconnected at their α carbon atoms via methine bridges (=CH−). The parent of porphyrin is porphine, a rare chemical compound of exclusively theoretical interest. Substituted porphines are called porphyrins. With a total of 26 π-electrons, of which 18 π-electrons form a planar, continuous cycle, the porphyrin ring structure is often described as aromatic. One result of the large conjugated system is that porphyrins typically absorb strongly in the visible region of the electromagnetic spectrum, i.e. they are deeply colored. The name "porphyrin" derives from the Greek word πορφύρα (''porphyra''), meaning ''purple''. Complexes of porphyrins Concomitant with the displacement of two N-''H'' protons, porphyrins bind metal ions in the N4 "pocket". The metal ion usually has a charge of 2+ or 3+. A schematic equation for these syntheses is shown: :H2porp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Texas At Austin
The University of Texas at Austin (UT Austin, UT, or Texas) is a public research university in Austin, Texas. It was founded in 1883 and is the oldest institution in the University of Texas System. With 40,916 undergraduate students, 11,075 graduate students and 3,133 teaching faculty as of Fall 2021, it is also the largest institution in the system. It is ranked among the top universities in the world by major college and university rankings, and admission to its programs is considered highly selective. UT Austin is considered one of the United States's Public Ivies. The university is a major center for academic research, with research expenditures totaling $679.8 million for fiscal year 2018. It joined the Association of American Universities in 1929. The university houses seven museums and seventeen libraries, including the LBJ Presidential Library and the Blanton Museum of Art, and operates various auxiliary research facilities, such as the J. J. Pickle Researc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
State Flag Of Texas
The flag of Texas is the official flag of the U.S. state of Texas. It is well known for its prominent single white star which gives the flag its commonly-used name: "Lone Star Flag". This lone star, in turn, gives rise to the state's nickname: "The Lone Star State". The flag, flown at homes and businesses statewide, is highly popular among Texans and is treated with a great degree of reverence and esteem within Texas. Along with the flag of Hawaii, it is one of two state flags to have previously served as a national flag of an independent country. In 2001, the North American Vexillological Association surveyed its members on the designs of the 72 U.S. state, territorial, and Canadian provincial flags and ranked the Texas flag second, behind New Mexico. Flag design The state flag is officially described by law as: History and adoption Legislation authorizing the flag was introduced in the Congress of the Republic of Texas on December 28, 1838, by Senator William H. Wharton. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buckyball (molecule)
Buckminsterfullerene is a type of fullerene with the formula C60. It has a cage-like fused-ring structure (truncated icosahedron) made of twenty hexagons and twelve pentagons, and resembles a soccer ball. Each of its 60 carbon atoms is bonded to its three neighbors. Buckminsterfullerene is a black solid that dissolves in hydrocarbon solvents to produce a violet solution. The compound was discovered in 1985 and has received intense study, although few real world applications have been found. Occurrence Buckminsterfullerene is the most common naturally occurring fullerene. Small quantities of it can be found in soot. It also exists in space. Neutral C60 has been observed in planetary nebulae and several types of star. The ionised form, C60+, has been identified in the interstellar medium, where it is the cause of several absorption features known as diffuse interstellar bands in the near-infrared. History Theoretical predictions of buckyball molecules appeared in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
