Taxine
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Taxine
Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. The amount of taxine alkaloids depends on the species of yew, with ''Taxus baccata'' and '' Taxus cuspidata'' containing the most. The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine. The taxine alkaloids are cardiotoxins with taxine B being the most active. Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. Provenance Taxine can be found in Taxus species: '' Taxus cuspidata, T. baccata'' (English yew), '' Taxus x media, Taxus canadensis, Taxus floridana,'' and '' Taxus brevifolia'' (Pacific or western yew). All of these species contain taxine in every part of the plant except in the aril, the fles ...
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Taxine B
Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. The amount of taxine alkaloids depends on the species of yew, with ''Taxus baccata'' and ''Taxus cuspidata'' containing the most. The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine. The taxine alkaloids are cardiotoxins with taxine B being the most active. Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. Provenance Taxine can be found in Taxus species: ''Taxus cuspidata, T. baccata'' (English yew), '' Taxus x media, Taxus canadensis, Taxus floridana,'' and ''Taxus brevifolia'' (Pacific or western yew). All of these species contain taxine in every part of the plant except in the aril, the fleshy co ...
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Taxus Cuspidata
''Taxus cuspidata'', the Japanese yew or spreading yew, is a member of the genus ''Taxus'', native to Japan, Korea, northeast China and the extreme southeast of Russia. It is an evergreen tree or large shrub growing to 10–18 m tall, with a trunk up to 60 cm diameter. The leaves are lanceolate, flat, dark green, 1–3 cm long and 2–3 mm broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flattish rows either side of the stem except on erect leading shoots where the spiral arrangement is more obvious. The seed cones are highly modified, each cone containing a single seed 4–8 mm long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, 8–12 mm long and wide and open at the end. The arils are mature 6–9 months after pollination. Individual trees from Sikhote-Alin are known to have been 1,000 years old. Uses It is widely grown in eastern Asi ...
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Taxus Baccata
''Taxus baccata'' is a species of evergreen tree in the family Taxaceae, native to western, central and southern Europe (including Britain and Ireland), northwest Africa, northern Iran, and southwest Asia.Rushforth, K. (1999). ''Trees of Britain and Europe''. Collins . It is the tree originally known as yew, though with other related trees becoming known, it may now be known as common yew, English yew, or European yew. It is primarily grown as an ornamental. Most parts of the plant are poisonous, with toxins that can be absorbed through inhalation and through the skin; consumption of even a small amount of the foliage can result in death. Taxonomy and naming The word ''yew'' is from Proto-Germanic ''*īwa-'', possibly originally a loanword from Gaulish ''*ivos'', compare Breton ''ivin,'' Irish '' ēo'', Welsh ''ywen'', French '' if'' (see Eihwaz for a discussion). In German it is known as ''Eibe''. ''Baccata'' is Latin for ''bearing berries''. The word ''yew'' as it was originally ...
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Taxus
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish bark, lanceolate, flat, dark-green leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is spread over 2–3 months, increasing the chances of successful seed d ...
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Taxus Baccata MHNT
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish bark, lanceolate, flat, dark-green leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is spread over 2–3 months, increasing the chances of successful seed di ...
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Taxus × Media
''Taxus ''×'' media'', sometimes known simply as ''Taxus media'', is a conifer (more specifically, a yew) created by the hybridization of English yew ''Taxus baccata'' and Japanese yew ''Taxus cuspidata''. This hybridization is thought to have been performed by the Massachusetts-based horticulturalist T.D. Hatfield in the early 1900s. '' Taxonomy and common naming Taxus × media is available in a large number of shrubby, often wide-spreading, cultivars under a variety of names. Description Like most yew species, ''T. ''×'' media'' prefers well-drained and well-watered soils, but has some degree of drought tolerance and in fact may die in conditions of excessive precipitation if the soil beneath the plant is not sufficiently well-drained. ''Taxus ''×'' media'' is among the smallest extant species in the genus ''Taxus'' and (depending upon cultivar) may not even grow to the size of what one would consider a typical tree. Immature shrubs are very small and achieve (over the ti ...
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Taxus Baccata MHNT Seed
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish Bark (botany), bark, lanceolate, flat, dark-green leaf, leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The conifer cone, seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red Berry (botany), berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by Thrush (bird), thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is sprea ...
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Taxane
Taxanes are a class of diterpenes. They were originally identified from plants of the genus ''Taxus'' (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer. Taxanes present difficulties in formulation as medicines because they are poorly soluble in water. Production As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesized. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of ''Corylus avellana'' (the common hazel plant) has been reported. Mechanism of action The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and ta ...
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Combustion Analysis
Combustion analysis is a method used in both organic chemistry and analytical chemistry to determine the elemental composition (more precisely empirical formula) of a pure organic compound by combusting the sample under conditions where the resulting combustion products can be quantitatively analyzed. Once the number of moles of each combustion product has been determined the empirical formula or a partial empirical formula of the original compound can be calculated. Applications for combustion analysis involve only the elements of carbon (C), hydrogen (H), nitrogen (N), and sulfur (S) as combustion of materials containing them convert these elements to their oxidized form (CO2, H2O, NO or NO2, and SO2) under high temperature high oxygen conditions. Notable interests for these elements involve measuring total nitrogen in food or feed to determine protein percentage, measuring sulfur in petroleum products, or measuring total organic carbon (TOC) in water. History The method was ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Archiv Der Pharmazie
The ''Archiv der Pharmazie'' (German pronunciation: arˈçiːf ˈdeːɐ̯ farmaˈtsiː English: ''Archive of Pharmacy'') is a monthly peer-reviewed scientific journal covering all aspects of chemistry in the life sciences. The journal was established in 1822 and is published by Wiley-VCH on behalf of the Deutsche Pharmazeutische Gesellschaft. Until 2019, the editor-in-chief was Holger Stark (Heinrich Heine University Düsseldorf). He was succeeded in 2020 by Andreas Link (University of Greifswald). History The first edition appeared in 1822 under the name ''Archiv des Apothekervereins im nördlichen Teutschland für die Pharmacie und ihre Huelfswissenschaften'' (English: ''Archive of the Pharmacists' Association in Northern Germany for Pharmacy and its Auxiliary Sciences''). From 1924 (volume 242) the journal was called ''Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft'' (English: ''Archive of Pharmacy and Reports from the German Pharmaceutical S ...
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