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Taraxein
Taraxein is a possibly nonexistent protein isolated from the blood of patients with schizophrenia, claimed by Robert Galbraith Heath to produce schizophrenia-like symptoms when injected into healthy subjects.Heath RG, Mårtens S, Leach BE, Cohen M, Angel C (1957): Effect on behavior in humans with the administration of taraxein. Am J Psychiatry, 114: 14–24. Despite initial interest, attempts at confirmation failed. The results are today commonly assumed to be due to self-deception.Alan Baumeistera, The Search for an Endogenous Schizogen: The Strange Case of Taraxein, Journal of the History of the Neurosciences: Basic and Clinical Perspectives Volume 20, Issue 2, 2011 p. 106-102 The name is derived from the Greek word τάραξις (taraxis), meaning disordered or confused mind. Taraxein was discovered during the investigation of the hypothesis that catecholamine metabolism is altered in schizophrenia. A blue substance was found in extracts from people with schizophrenia but not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Galbraith Heath
Robert Galbraith Heath (May 9, 1915 – September 21, 1999) was an American psychiatrist. He followed the theory of biological psychiatry that organic defects were the sole source of mental illness, and that consequently mental problems were treatable by physical means. He published 425 papers and three books. One of his first papers is dated 1946. He was profiled as a "famous American psychiatrist" in 1983 by ''Psychiatric Annals''. Heath founded the Department of Psychiatry and Neurology at Tulane University, New Orleans, in 1949 and remained its chairman until 1980. He performed many experiments there involving electrical stimulation of the brain via surgically implanted electrodes. He placed deep brain stimulation (DBS) electrodes into the brains of more than 54 patients. Indeed, he has been cited as the first, or one of the first, researcher(s) to have placed electrodes deep into the brains of living human patients. It has been suggested that this work was financed in part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-deception
Self-deception is a process of denying or rationalizing away the relevance, significance, or importance of opposing evidence and logical argument. Self-deception involves convincing oneself of a truth (or lack of truth) so that one does not reveal any self-knowledge of the deception. Brief history While Freudian analysis of the conscious and the unconscious minds dominated the field, psychological scientists in the 1970s became curious about how those two seemingly separate worlds could work together. The lack of mechanistic models available to this line of research, led to the debate being unresolved. Later, the focus has been shifted to vision-related research in social psychology. Theorization Analysis The traditional paradigm of self-deception is modeled after ''interpersonal'' deception, where ''A'' intentionally gets ''B'' to believe some proposition ''p'', all the while knowing or believing truly ¬''p'' (not ''p''). Such deception is intentional and requires the decei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catecholamine
A catecholamine (; abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine. Catechol can be either a free molecule or a substituent of a larger molecule, where it represents a 1,2-dihydroxybenzene group. Catecholamines are derived from the amino acid tyrosine, which is derived from dietary sources as well as synthesis from phenylalanine. Catecholamines are water-soluble and are 50% bound to plasma proteins in circulation. Included among catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. Release of the hormones epinephrine and norepinephrine from the adrenal medulla of the adrenal glands is part of the fight-or-flight response. Tyrosine is created from phenylalanine by hydroxylation by the enzyme phenylalanine hydroxylase. Tyrosine is also ingested directly from dietary protein. Catecholamine-secreting cells use sev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Septal Nuclei
The septal area (medial olfactory area), consisting of the lateral septum and medial septum, is an area in the lower, posterior part of the medial surface of the frontal lobe, and refers to the nearby septum pellucidum. The septal nuclei are located in this area. The septal nuclei are composed of medium-size neurons which are classified into dorsal, ventral, medial, and caudal groups. The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus. The septal nuclei are essential in generating the theta rhythm of the hippocampus. The septal area (medial olfactory area) has no relation to the sense of smell, but it is considered a pleasure zone in animals. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens. In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly (i.e., press a bar to rece ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louisiana State Penitentiary
The Louisiana State Penitentiary (known as Angola, and nicknamed the "Alcatraz of the South", "The Angola Plantation" and "The Farm"Sutton, Keith "Catfish".Out There: Angola angling. ''ESPN Outdoors''. May 31, 2006. Retrieved on August 25, 2010.) is a maximum-security prison farm in Louisiana operated by the Louisiana Department of Public Safety & Corrections. It is named "Angola" after the former slave plantation that occupied this territory. The plantation was named after the country of Angola from which many slaves originated before arriving in Louisiana. Angola is the largest maximum-security prison in the United States with 6,300 prisoners and 1,800 staff, including corrections officers, janitors, maintenance, and wardens. Due to these large numbers, it has been given the nickname "a gated community". Located in West Feliciana Parish, the prison is set between oxbow lakes on the east side of a bend of the Mississippi River, thus flanked on three sides by water. It lies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunoglobulins
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few varian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autoimmune
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, post-infectious IBS, diabetes mellitus type 1, Henoch–Schönlein purpura (HSP) sarcoidosis, systemic lupus erythematosus (SLE), Sjögren syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), ankylosing spondylitis, polymyositis (PM), dermatomyositis (DM), Alopecia Areata and multiple sclerosis (MS). Autoimmune diseases are very often treated with steroids. Autoimmunity means presence of antibodies or T cells that react with self-protein and is present in all individuals, even in normal health state. It causes autoimmune diseases if self-reactivity can lead to tissue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Proteins
Blood-proteins, also termed plasma proteins, are proteins present in blood plasma. They serve many different functions, including transport of lipids, hormones, vitamins and minerals in activity and functioning of the immune system. Other blood proteins act as enzymes, complement components, protease inhibitors or kinin precursors. Contrary to popular belief, haemoglobin is not a blood protein, as it is carried within red blood cells, rather than in the blood serum. Serum albumin accounts for 55% of blood proteins, is a major contributor to maintaining the oncotic pressure of plasma and assists, as a carrier, in the transport of lipids and steroid hormones. Globulins make up 38% of blood proteins and transport ions, hormones, and lipids assisting in immune function. Fibrinogen comprises 7% of blood proteins; conversion of fibrinogen to insoluble fibrin is essential for blood clotting. The remainder of the plasma proteins (1%) are regulatory proteins, such as enzymes, proenzym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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