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Suman Kumar Dhar
Suman Kumar Dhar (born 1968) is an Indian molecular biologist and a professor at the ''Special Centre for Molecular Medicine'' of Jawaharlal Nehru University. He is known for his studies on the DNA replication and cell cycle regulation in Helicobacter pylori and Plasmodium falciparum, two pathogens affecting humans. An elected fellow of the National Academy of Sciences, India, Indian National Science Academy and the Indian Academy of Sciences, he is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology in 2010. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2012, for his contributions to biological sciences. Biography Suman Kumar Dhar, born on 6 March 1968 in the Indian state of West Bengal, graduated in chemistry from Burdwan Univers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kalimpong
Kalimpong (Hindi: कलिम्पोंग) is a town and the headquarters of an eponymous district in the Indian state of West Bengal. It is located at an average elevation of . The town is the headquarters of the Kalimpong district. The region comes under Gorkhaland Territorial Administration which is an autonomous governing body within the state of West Bengal. The Indian Army's 27 Mountain Division is located on the outskirts of the city. Kalimpong is known for its educational institutions, many of which were established during the British colonial period. It used to be a gateway in the trade between Tibet and India before China's annexation of Tibet and the Sino-Indian War. Kalimpong and neighbouring Darjeeling were major centres calling for a separate Gorkhaland state in the 1980s, and more recently in 2010. The municipality sits on a ridge overlooking the Teesta River and is a tourist destination owing to its temperate climate, natural environment and proximity to p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Cycle Regulation
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of its cytoplasm, chromosomes and other components into two daughter cells in a process called cell division. In cells with nuclei (eukaryotes, i.e., animal, plant, fungal, and protist cells), the cell cycle is divided into two main stages: interphase and the mitotic (M) phase (including mitosis and cytokinesis). During interphase, the cell grows, accumulating nutrients needed for mitosis, and replicates its DNA and some of its organelles. During the mitotic phase, the replicated chromosomes, organelles, and cytoplasm separate into two new daughter cells. To ensure the proper replication of cellular components and division, there are control mechanisms known as cell cycle checkpoints after each of the key steps ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastric Ulcer
Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain and upper abdominal pain that improves with eating. With a gastric ulcer, the pain may worsen with eating. The pain is often described as a burning or dull ache. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of cases. Common causes include the bacteria ''Helicobacter pylori'' and non-steroidal anti-inflammatory drugs (NSAIDs). Other, less common causes include tobacco smoking, stress as a result of other serious health conditions, Behçet's di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acriflavine
Acriflavine (INN: acriflavinium chloride) is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names. Uses Medical use Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness and as a topical antiseptic. Other uses Acriflavine is used in biochemistry for fluorescently labeling high molecular weight RNA. It is used as treatment for external fungal infections of aquarium fish. Research In an animal model, acriflavine has been shown to inhibit HIF-1, which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use. Acriflavine might be effective ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geminin
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the ''GMNN'' gene. A nuclear protein present in most eukaryotes and highly conserved across species, numerous functions have been elucidated for geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. One example of its function is the inhibition of Cdt1. History Geminin was originally identified as an inhibitor of DNA replication and substrate of the anaphase-promoting complex. Coincidentally, geminin was also shown to expand the neural plate in the developing Xenopus embryo. Structure Geminin is a nuclear protein made up of about 200 amino acids, with a molecular weight of approximately 25 kDa. It contains an atypical leucine zipper coiled-coil domain. It has no known enzymatic activity nor DNA binding motifs. Function Cell cycle control Geminin is absent during G1 phase and accumulates through S, G2 pha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORC6
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene. Background The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. Function The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Interactions ORC6 has been shown to interact with MCM5, ORC2, Replication protein A1, ORC4, DBF4, ORC3, CDC45-related protein, MCM4 and Cell divisio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amoebiasis
Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba ''Entamoeba histolytica''. Amoebiasis can be present with no, mild, or severe symptoms. Symptoms may include lethargy, loss of weight, colonic ulcerations, abdominal pain, diarrhea, or bloody diarrhea. Complications can include inflammation and ulceration of the colon with tissue death or perforation, which may result in peritonitis. Anemia may develop due to prolonged gastric bleeding. Microbial cyst#In protists, Cysts of ''Entamoeba'' can survive for up to a month in soil or for up to 45 minutes under fingernails. Invasion of the intestinal lining results in bloody diarrhea. If the parasite reaches the bloodstream it can spread through the body, most frequently ending up in the liver where it can cause amoebic liver abscesses. Liver abscesses can occur without previous diarrhea. Diagnosis is typically made by stool examination using microscopy, but it can be difficult to distingu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Entamoeba Histolytica
''Entamoeba histolytica'' is an anaerobic parasitic amoebozoan, part of the genus ''Entamoeba''. Predominantly infecting humans and other primates causing amoebiasis, ''E. histolytica'' is estimated to infect about 35-50 million people worldwide. ''E. histolytica'' infection is estimated to kill more than 55,000 people each year. Previously, it was thought that 10% of the world population was infected, but these figures predate the recognition that at least 90% of these infections were due to a second species, ''E. dispar''. Mammals such as dogs and cats can become infected transiently, but are not thought to contribute significantly to transmission. The word '' histolysis'' literally means disintegration and dissolution of organic tissues. Transmission The active (trophozoite) stage exists only in the host and in fresh loose feces; cysts survive outside the host in water, in soils, and on foods, especially under moist conditions on the latter. The infection can occur when a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2016 JNU Protests
On 9 February 2016, some students of Jawaharlal Nehru University (JNU) held a protest on their campus against the capital punishment meted out to the 2001 Indian Parliament attack convict Afzal Guru, and Kashmiri separatist Maqbool Bhat. The organizers of the event were former members of the Democratic Students' Union (DSU). The event was held despite the university administration withdrawing permission for the event shortly before it was due to begin, due to protests by members of the student union of ABVP. The event saw clashes between various student groups. A video was circulated by Indian news channel Zee news in which a small group of individuals, whom a later investigation described as outsiders to the university wearing masks, shouted "anti-India" slogans. The slogans were criticized by many individuals, including political leaders and students of JNU. Four days after the event, JNU Students' Union president Kanhaiya Kumar was arrested by the Delhi police and charged wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brigham And Women’s Hospital
Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two founding members of Mass General Brigham, the largest healthcare provider in Massachusetts. Sunil Eappen serves as the hospital's current president. Brigham and Women's Hospital conducts the second largest (behind MGH) hospital-based research program in the world, with an annual research budget of more than $630 million. Pioneering achievements at BWH have included the world's first successful heart valve operation and the world's first solid organ transplant. In the 2020 '' U.S. News & World Report'' hospital rankings, BWH was ranked second in Massachusetts (behind MGH) and twelfth nationally. History Brigham and Women's Hospital was established with the 1980 merger of three Harvard-affiliated hospitals: Peter Bent Brigham Hospital ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Nebraska
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shanti Swarup Bhatnagar Prize For Science And Technology
The Shanti Swarup Bhatnagar Prize for Science and Technology (SSB) is a science award in India given annually by the Council of Scientific and Industrial Research (CSIR) for notable and outstanding research, Applied science, applied or Fundamental science, fundamental, in biology, chemistry, environmental science, engineering, mathematics, medicine, and physics. The prize recognizes outstanding Indian work (according to the view of Council of Scientific and Industrial Research, CSIR awarding committee) in science and technology. It is the most coveted award in Interdisciplinarity, multidisciplinary science in India. The award is named after the founder Director of the Council of Scientific & Industrial Research, Shanti Swaroop Bhatnagar, Shanti Swarup Bhatnagar. It was first awarded in 1958. Any citizen of India engaged in research in any field of science and technology up to the age of 45 years is eligible for the prize. The prize is awarded on the basis of contributions made thr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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