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Sulfapyridine
Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than the development of resistance by bacteria, is the main reason for its decline in use. History M&B 693 was one of the first generation of sulfonamide antibiotics. It was discovered by Lionel Whitby at the British firm May & Baker Ltd and logged in their Test Book on 2 November, 1937 under Code No M&B 693. During the aftermath to the disastrous convoy SC7, in October 1940, Surgeon-Lieut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
May & Baker
May & Baker was a British chemical company founded by John May and William Gerrard Baker in Wandsworth, London in 1839. They initially specialized in the manufacture of chemicals derived from mercury and bismuth. Over the years they diversified into other chemical fields including photographic chemicals, pharmaceuticals, agrochemicals, and chemicals for research and development. The company was bought by Établissements Poulenc Frères (later to become Société des Usines Chimiques Rhône-Poulenc) in 1922, and subsequently moved to Dagenham, Essex, although it continued to trade under the May & Baker name. During this time May & Baker branched into pharmaceuticals, with one of their major discoveries being sulphapyridine (M&B 693), first produced in 1937. This compound, May & Baker's most famous product, was one of the first generation of sulfonamide antibiotics. During WW2, M&B 693 saved many thousands of lives, including Sir Winston Churchill who was treated with it for p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide Antibiotics
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Compound
Azo compounds are organic compounds bearing the functional group diazenyl (, in which R and R′ can be either aryl or alkyl groups). IUPAC defines azo compounds as: "Derivatives of diazene (diimide), , wherein both hydrogens are substituted by hydrocarbyl groups, e.g. azobenzene or diphenyldiazene." The more stable derivatives contain two aryl groups. The group is called an ''azo group'' (, ). Many textile and leather articles are dyed with azo dyes and pigments. Aryl azo compounds Aryl azo compounds are usually stable, crystalline species. Azobenzene is the prototypical aromatic azo compound. It exists mainly as the ''trans'' isomer, but upon illumination, converts to the ''cis'' isomer. Aromatic azo compounds can be synthesized by azo coupling, which entails an electrophilic substitution reaction where an aryl diazonium cation is attacked by another aryl ring, especially those substituted with electron-donating groups: :ArN2+ + Ar'H -> ArN=NAr' + H+ Since diazoniu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesalamine
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is generally used for mildly to moderately severe disease. It is taken by mouth or rectally. The formulations which are taken by mouth appear to be similarly effective. Common side effects include headache, nausea, abdominal pain, and fever. Serious side effects may include pericarditis, liver problems, and kidney problems. Use in pregnancy and breastfeeding appears safe. In people with a sulfa allergy certain formulations may result in problems. Mesalazine is an aminosalicylate and anti-inflammatory. It works by direct contact with the intestines. Mesalazine was approved for medical use in the United States in 1987. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication and sold under many brand names worldwide. In 2020, it was the 184th mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfasalazine
Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. It is taken by mouth. Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Severe side effects include bone marrow suppression, liver problems, Stevens–Johnson syndrome, and kidney problems. It should not be used in people allergic to aspirin or sulfonamide. Use during pregnancy appears to be safe for the baby. Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works. One proposed mechanism is the inhibition of prostaglandins, resulting in local anti-inflammatory effects in the colon. The medication is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid. That which is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Winston Churchill
Sir Winston Leonard Spencer Churchill (30 November 187424 January 1965) was a British statesman, soldier, and writer who served as Prime Minister of the United Kingdom twice, from 1940 to 1945 Winston Churchill in the Second World War, during the Second World War, and again from 1951 to 1955. Apart from two years between 1922 and 1924, he was a Member of Parliament (United Kingdom), Member of Parliament (MP) from 1900 to 1964 and represented a total of five UK Parliament constituency, constituencies. Ideologically an Economic liberalism, economic liberal and British Empire, imperialist, he was for most of his career a member of the Conservative Party (UK), Conservative Party, which he led from 1940 to 1955. He was a member of the Liberal Party (UK), Liberal Party from 1904 to 1924. Of mixed English and American parentage, Churchill was born in Oxfordshire to Spencer family, a wealthy, aristocratic family. He joined the British Army in 1895 and saw action in British Raj, Br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SS Assyrian (1914)
SS ''Assyrian'' was a cargo ship that was built in Hamburg for German owners in 1914, transferred to British owners in 1920 as war reparations and sunk by a U-boat in 1940. She was launched as MS ''Fritz'', and when she changed owners in 1920 she was renamed MS ''Assyrian''. She had been built as a motor ship but in 1925 she was converted to a steamship and became SS ''Assyrian''. From MS ''Fritz'' to SS ''Assyrian'' Blohm + Voss of Hamburg built the ship, completing her as MS ''Fritz'' in August 1914 for Woermann-Linie, who registered her in Hamburg. In 1919 she was designated for war reparations and in 1920 she was acquired by the British Ellerman and Papayanni Lines, who renamed her ''Assyrian'' and registered her in Liverpool. In 1925 Ellerman's had her converted from diesel to steam propulsion with a pair of three-cylinder triple-expansion steam engines built by Cooper and Greig of Dundee, Scotland and rated at a combined power output of 280 NHP. Steam came from a pair of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMS Leith (U36)
HMS ''Leith'' was a sloop of the Royal Navy that served in the Second World War. Building, commissioning and early service ''Leith'' was ordered on 1 November 1932 under the 1931 Programme. She was laid down at Devonport Dockyard on 6 February 1933, launched on 9 September 1933 and commissioned on 10 July 1934. She was initially assigned to the New Zealand Division of the Royal Navy, manned by the Chatham Port Division. ''Leith'' arrived at Auckland on 13 November 1934, and was deployed in the Pacific and locally in New Zealand waters. She was recommissioned in December 1936 in order to continue to serve with the New Zealand Division and was again in July 1939. She had an active career in the Pacific, making numerous visits to Colonial possessions, and on one occasion taking Salote Tupou III, Queen of Tonga on a visit to outlying islands. Wartime career The Pacific and return to the UK The outbreak of the Second World War saw ''Leith'' still in the Pacific. In September 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convoy SC 7
SC 7 was the code name for a large Allied World War II convoy of 35 merchant ships and six escorts, which sailed eastbound from Sydney, Nova Scotia, for Liverpool and other United Kingdom ports on 5 October 1940. While crossing the Atlantic, the convoy was intercepted by one of the first ''Kriegsmarine'' submarine wolfpacks. During the ensuing battle, the escort was completely overwhelmed and 20 of the 35 cargo vessels were sunk and 2 more damaged, with 141 lives lost. The disastrous outcome of the convoy demonstrated the German submarines' potential of being able to work more efficiently using wolfpack tactics and the inadequacy of British anti-submarine tactics at the time. Ships of the convoy The slow convoy SC 7 left Sydney, Nova Scotia on 5 October 1940 bound for Liverpool and other British ports. The convoy was supposed to make but several merchant ships were much slower, necessitating a further reduced speed. The convoy consisted of older, smaller ships, mostly with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lionel Whitby
Brigadier Sir Lionel Ernest Howard Whitby, CVO, MC (8 May 1895 – 24 November 1956) was a British haematologist, British Army officer and academic. He served as Regius Professor of Physic at the University of Cambridge from 1945 to 1956, Master of Downing College, Cambridge from 1947 to 1956, and Vice-Chancellor of the University of Cambridge from 1951 to 1953. Early life Whitby was born on 8 May 1895 in Yeovil, Somerset. He was the second of three sons born to Benjamin Whitby and his wife, Jane Elizabeth Whitby (née Milborne). He was educated at King's College, an independent school in Taunton, Somerset, and at Bromsgrove School, an independent school in Bromsgrove, Worcestershire. In 1914, having completed his schooling, he was awarded a senior open scholarship to attend Downing College, Cambridge. However, he did not immediately take up his place at the University of Cambridge, and instead enlisted in the military at the start of World War I. Having returned from military ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
