Streptomyces Natalensis
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Streptomyces Natalensis
''Streptomyces natalensis'' is a bacterial species in the genus ''Streptomyces''. Uses Natamycin Natamycin, also known as pimaricin, is an antifungal medication used to treat fungal infections around the eye. This includes infections of the eyelids, conjunctiva, and cornea. It is used as eyedrops. Natamycin is also used in the food indust ... is an antifungal agent produced during fermentation by ''S. natalensis''. References Further reading * * External links natalensis {{Streptomyces-stub ...
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Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ...
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Actinomycetota
The ''Actinomycetota'' (or ''Actinobacteria'') are a phylum of all gram-positive bacteria. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to soil systems. In soil they help to decompose the organic matter of dead organisms so the molecules can be taken up anew by plants. While this role is also played by fungi, ''Actinomycetota'' are much smaller and likely do not occupy the same ecological niche. In this role the colonies often grow extensive mycelia, like a fungus would, and the name of an important order of the phylum, '' Actinomycetales'' (the actinomycetes), reflects that they were long believed to be fungi. Some soil actinomycetota (such as ''Frankia'') live symbiotically with the plants whose roots pervade the soil, fixing nitrogen for the plants in exchange for access to some of the plant's saccharides. Other species, such as many members of the genus '' Mycobacterium'', ar ...
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Actinomycetia
The Actinomycetia are a class of bacteria. Taxonomy The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). * Acidothermales Sen et al. 2014 * Actinomycetales Buchanan 1917 (Approved Lists 1980) * Actinopolysporales Goodfellow and Trujillo 2015 * Bifidobacteriales Stackebrandt et al. 1997 * Catenulisporales Donadio et al. 2015 * Cryptosporangiales Nouioui et al. 2018 * Frankiales Sen et al. 2014 * Geodermatophilales Sen et al. 2014 * Glycomycetales Labeda 2015 * Jatrophihabitantales Salam et al. 2020 * Jiangellales Tang et al. 2015 * Kineosporiales Kämpfer 2015 * Micrococcales Prévot 1940 (Approved Lists 1980) * Micromonosporales Genilloud 2015 * Mycobacteriales Janke 1924 (Approved Lists 1980) * Nakamurellales Sen et al. 2014 * Propionibacteriales (Rainey et al. 1997) Patrick and McDowell 2015 * Pseudonocardiales Labeda and Goodfellow 2015 * Sporichthyales ...
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Actinomycetales
The Actinomycetales is an order of Actinomycetota. A member of the order is often called an actinomycete. Actinomycetales are generally gram-positive and anaerobic and have mycelia in a filamentous and branching growth pattern. Some actinomycetes can form rod- or coccoid-shaped forms, while others can form spores on aerial hyphae. Actinomycetales bacteria can be infected by bacteriophages, which are called actinophages. Actinomycetales can range from harmless bacteria to pathogens with resistance to antibiotics. Reproduction Actinomycetales have 2 main forms of reproduction: spore formation and hyphae fragmentation. During reproduction, Actinomycetales can form conidiophores, sporangiospores, and oidiospores. In reproducing through hyphae fragmentation, the hyphae formed by Actinomycetales can be a fifth to half the size of fungal hyphae, and bear long spore chains. Presence and associations Actinomycetales can be found mostly in soil and decaying organic matter, as well as in ...
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Streptomycetaceae
The ''Streptomycetaceae'' are a family of ''Actinomycetota'', making up the monotypic order ''Streptomycetales''. It includes the important genus ''Streptomyces''. This was the original source of many antibiotics, namely streptomycin, the first antibiotic against tuberculosis. Genomics Sequence alignments of actinomycetotal genomes have led to the identification of three conserved signature indels which are unique to the order Streptomycetales. The enzyme PBGD contains a four-amino-acid insertion which is present in all ''Streptomyces'' species and ''Kitasatospora setae'', but not any other Actinomycetota. Similarly, a one- amino-acid insertion is present in a conserved region of adenylate kinase and is found in all ''Streptomyces'' species and '' K. setae'', but is not found in any other Actinomycetota. Five conserved signature proteins have also been identified which are present in various sequenced ''Streptomyces'' species, but not in ''K. setae''; however, as the complete ...
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Streptomyces
''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Streptomycetes are characterised by a complex secondary metabolism. They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, grisemycin, bottromycins and chloramphenicol). The antibiotic streptomycin takes its name directly from ''Streptomyces''. Streptomycetes are infrequent pathogens, though infections in humans, such as mycetoma, can be caused by '' S. somaliensis'' and '' S. sudanensis'', and in plants can be caused by '' S. cavi ...
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Natamycin
Natamycin, also known as pimaricin, is an antifungal medication used to treat fungal infections around the eye. This includes infections of the eyelids, conjunctiva, and cornea. It is used as eyedrops. Natamycin is also used in the food industry as a preservative. Allergic reactions may occur. It is unclear if medical use during pregnancy or breastfeeding is safe. It is in the macrolide and polyene families of medications. It results in fungal death by altering the cell membrane. Natamycin was discovered in 1955 and approved for medical use in the United States in 1978. It is on the World Health Organization's List of Essential Medicines. It is produced by fermentation of certain types of the bacterium ''Streptomyces''. Uses Medical Natamycin is used to treat fungal infections, including '' Candida'', ''Aspergillus'', ''Cephalosporium'', ''Fusarium'', and ''Penicillium''. It is applied topically as a cream, in eye drops, or (for oral infections) in a lozenge. Natamyc ...
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