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Streptoalloteichus
''Streptoalloteichus'' is a genus of bacteria within the family ''Pseudonocardiaceae'' that contains two known species: * '' S. hindustanus'', which is known for the production of tallysomycin, an antitumor antibiotic; * '' S. tenebrarius'', which is known for production of tobramycin Tobramycin is an aminoglycoside antibiotic derived from '' Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas ..., and which was previously classified as ''Streptomyces tenebrarius''. References External links''Streptoalloteichus''J.P. Euzéby: List of Prokaryotic names with Standing in Nomenclature Pseudonocardiales Bacteria genera {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptoalloteichus Hindustanus
''Streptoalloteichus'' is a genus of bacteria within the family ''Pseudonocardiaceae'' that contains two known species: * '' S. hindustanus'', which is known for the production of tallysomycin, an antitumor antibiotic; * '' S. tenebrarius'', which is known for production of tobramycin Tobramycin is an aminoglycoside antibiotic derived from '' Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas ..., and which was previously classified as ''Streptomyces tenebrarius''. References External links''Streptoalloteichus''J.P. Euzéby: List of Prokaryotic names with Standing in Nomenclature Pseudonocardiales Bacteria genera {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptoalloteichus Tenebrarius
''Streptoalloteichus tenebrarius'' is a bacterium that biosynthesizes the aminoglycoside antibiotics tobramycin Tobramycin is an aminoglycoside antibiotic derived from '' Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas ... and apramycin. References Streptomyces {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudonocardiaceae
The Pseudonocardiaceae are a family of bacteria in the order Actinomycetales and the only member of the suborder Pseudonocardineae. Genomics The species within the family Pseudonocardiaceae form a distinct clade in phylogenetic trees based on concatenated protein sequences. Additionally, ''Nakamurella multipartite'', currently part of the order Frankiales, also formed a clade with the Pseudonocardiaceae species in 100% of the bootstrap replications of the phylogenetic trees. A conserved signature indel has been identified which is found in ''N. multipartite'' and all but one of the Pseudonocardiaceae species. This one-amino-acid insertion in UMP kinase serves to both provide a molecular marker for nearly all of the Pseudonocardiaceae and suggests ''N. multipartite'' is closely related to this group. Some evidence also suggests the orders Pseudonocardiales and Corynebacteriales are closely related. Several conserved signature indels have been identified which are found in both P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudonocardiales
The Pseudonocardiaceae are a family of bacteria in the order Actinomycetales and the only member of the suborder Pseudonocardineae. Genomics The species within the family Pseudonocardiaceae form a distinct clade in phylogenetic trees based on concatenated protein sequences. Additionally, ''Nakamurella multipartite'', currently part of the order Frankiales, also formed a clade with the Pseudonocardiaceae species in 100% of the bootstrap replications of the phylogenetic trees. A conserved signature indel has been identified which is found in ''N. multipartite'' and all but one of the Pseudonocardiaceae species. This one-amino-acid insertion in UMP kinase serves to both provide a molecular marker for nearly all of the Pseudonocardiaceae and suggests ''N. multipartite'' is closely related to this group. Some evidence also suggests the orders Pseudonocardiales and Corynebacteriales are closely related. Several conserved signature indels have been identified which are found in both ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antitumor Antibiotic
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals ( signal transduction). The development of therapies with specific molecular or genetic targets, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tobramycin
Tobramycin is an aminoglycoside antibiotic derived from '' Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas''. It was patented in 1965, and approved for medical use in 1974. It is on the World Health Organization's List of Essential Medicines. Medical uses Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations both have low systemic absorption. The formulation for injection is branded Nebcin. The nebulised formulation (brand name Tobi) is indicated in the treatment of exacerbations of chronic infection with ''Pseudomonas aeruginosa'' in people diagnosed with cystic fibrosis. Tobrex eye drops are a 0.3% t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
