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Sticky Mouse
Sticky mouse is a murine possessing a gene mutation in the enzyme alanyl-tRNA synthetase (AARS). The sticky mouse, with this particular mutation, presents a good model in which to investigate mechanisms of neuronal degeneration. Its most immediately obvious symptom is a sticky secretion on the mouse's fur (thus the name); however, it is accompanied by lack of muscle control, ataxia, alopecia, loss of Purkinje cells in the cerebellum, and eventually, death. Sticky mouse is one of several animal mutants that are known to have problems in mRNA translation and are used in studies. See also * Wasted mouse (wst) - EEF1A2 defect * Harlequin mouse * Reeler - RELN defect * Shaking rat Kawasaki A laboratory rat or lab rat is a brown rat of the subspecies '' Rattus norvegicus domestica'' which is bred and kept for scientific research. While less commonly used for research than mice (see laboratory mouse), rats have served as an importa ... - RELN defect References External lin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
House Mouse
The house mouse (''Mus musculus'') is a small mammal of the order Rodentia, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus '' Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the semi-tame populations near human activity. The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually agouti coloured), but domesticated fancy mice and laboratory mice ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodent Diseases
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are native to all major land masses except for New Zealand, Antarctica, and several oceanic islands, though they have subsequently been introduced to most of these land masses by human activity. Rodents are extremely diverse in their ecology and lifestyles and can be found in almost every terrestrial habitat, including human-made environments. Species can be arboreal, fossorial (burrowing), saltatorial/richochetal (leaping on their hind legs), or semiaquatic. However, all rodents share several morphological features, including having only a single upper and lower pair of ever-growing incisors. Well-known rodents include mice, rats, squirrels, prairie dogs, porcupines, beavers, guinea pigs, and hamsters. Rabbits, hares, and pikas, whose ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shaking Rat Kawasaki
A laboratory rat or lab rat is a brown rat of the subspecies '' Rattus norvegicus domestica'' which is bred and kept for scientific research. While less commonly used for research than mice (see laboratory mouse), rats have served as an important animal model for research in psychology and biomedical science. Origins In 18th century Europe, wild brown rats ran rampant and this infestation fueled the industry of rat-catching. Rat-catchers would not only make money by trapping the rodents, but also by selling them for food or, more commonly, for rat-baiting. Rat-baiting was a popular sport, which involved filling a pit with rats and timing how long it took for a terrier to kill them all. Over time, breeding the rats for these contests may have produced variations in color, notably the albino and hooded varieties. The first time one of these albino mutants was brought into a laboratory for a study was in 1828 for an experiment on fasting. Over the next 30 years, rats were u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reeler
A reeler is a mouse mutant, so named because of its characteristic "reeling" gait. This is caused by the profound underdevelopment of the mouse's cerebellum, a segment of the brain responsible for locomotion. The mutation is autosomal and recessive, and prevents the typical cerebellar folia from forming. Cortical neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the central nervous system. The reason is the lack of Reelin, an extracellular matrix glycoprotein, which, during the corticogenesis, is secreted mainly by the Cajal-Retzius cells. In the reeler neocortex, cortical plate neurons are aligned in a practically inverted fashion (‘‘outside-in’’). In the ventricular zone of the cortex fewer neurons have been found to have radial glial processes. In the dentate gyrus of hippocampus, no characteristic radial glial scaffold is formed and no compact granule cell layer is established. Therefore, the reeler m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harlequin Mouse
Harlequin (; it, Arlecchino ; lmo, Arlechin, Bergamasque pronunciation ) is the best-known of the ''zanni'' or comic servant characters from the Italian ''commedia dell'arte'', associated with the city of Bergamo. The role is traditionally believed to have been introduced by Zan Ganassa in the late 16th century, was definitively popularized by the Italian actor Tristano Martinelli in Paris in 1584–1585, and became a stock character after Martinelli's death in 1630. The Harlequin is characterized by his checkered costume. His role is that of a light-hearted, nimble, and astute servant, often acting to thwart the plans of his master, and pursuing his own love interest, Columbina, with wit and resourcefulness, often competing with the sterner and melancholic Pierrot. He later develops into a prototype of the romantic hero. Harlequin inherits his physical agility and his trickster qualities, as well as his name, from a mischievous " devil" character in medieval passion p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EEF1A2
Elongation factor 1-alpha 2 is a protein that in humans is encoded by the ''EEF1A2'' gene. Function This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform ( alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. Clinical significance This gene may be critical in the development of ovarian cancer Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different c .... Regulation EEF1A2 is a direct target of miRNA-663 and miRNA-744. References Further reading * * * * * * * * * * * * * * External links * {{gene-20-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wasted Mouse
Wasted may refer to: Arts, entertainment, and media Literature *'' Wasted: Tales of a GenX Drunk'', a 1997 memoir by Mark Judge *'' Wasted: A Memoir of Anorexia and Bulimia'', a 1998 autobiography by Marya Hornbacher *'' Wasted: A Childhood Stolen, An Innocence Betrayed, A Life Redeemed'', a 2008 memoir by Mark Johnson Music EPs * ''Wasted'' (EP), by L.A. Guns Songs * "Wasted" (Carrie Underwood song) * "Wasted" (Def Leppard song) * "Wasted" (Gucci Mane song) * "Wasted" (Jennifer Paige song) * "Wasted" (Juice Wrld song) * "Wasted" (Margaret song) * "Wasted" (Peking Duk song) * "Wasted" (Tiësto song) *"Wasted", by Ally Ryan *"Wasted", by And One *"Wasted", by Angus & Julia Stone from ''A Book Like This'' *"Wasted", by Anis Don Demina *"Wasted", by Black Flag from ''Nervous Breakdown'' *"Wasted", by Blancmange from ''Happy Families'' *"Wasted", by Cartel from ''Cartel'' *"Wasted", by Circle Jerks from ''Group Sex'' *"Wasted", by Demi Lovato from ''Holy Fvck'' *"Wasted", by Digga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal
Animals are multicellular, eukaryotic organisms in the Kingdom (biology), biological kingdom Animalia. With few exceptions, animals Heterotroph, consume organic material, Cellular respiration#Aerobic respiration, breathe oxygen, are Motility, able to move, can Sexual reproduction, reproduce sexually, and go through an ontogenetic stage in which their body consists of a hollow sphere of Cell (biology), cells, the blastula, during Embryogenesis, embryonic development. Over 1.5 million Extant taxon, living animal species have been Species description, described—of which around 1 million are Insecta, insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from to . They have Ecology, complex interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology. Most living animal species are in Bilateria, a clade whose members have a Symmetry in biology#Bilate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
House Mouse
The house mouse (''Mus musculus'') is a small mammal of the order Rodentia, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus '' Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the semi-tame populations near human activity. The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually agouti coloured), but domesticated fancy mice and laboratory mice ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
