Stephen L. Mayo
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Stephen L. Mayo
Stephen L. Mayo (born 1961) is a professor at the California Institute of Technology, where he is the William K. Bowes Jr. Leadership Chair in the Division of Biology and Biological Engineering, and the Bren Professor of Biology and Chemistry. His research focuses on structural biology and the development of computational methods for protein design. Mayo was elected to the United States National Academy of Sciences in 2004 and was appointed to a six-year term on the National Science Board in 2013. Early life and education One of three sons, Mayo was born in 1961. His father had a career in the Air Force and his mother worked as a teacher's aide. Mayo attended Pennsylvania State University as an undergraduate and received a B.S. in chemistry in 1983. He received his Ph.D. from Caltech in 1987, after working on several projects primarily with Harry B. Gray and Bill Goddard. While a graduate student, Mayo co-founded a company, Molecular Simulations, Inc., which would later become Acc ...
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National Science Board
The National Science Board (NSB) of the United States establishes the policies of the National Science Foundation (NSF) within the framework of applicable national policies set forth by the President and the Congress. The NSB also serves as an independent policy advisory body to the President and Congress on science and engineering research and education issues. The Board has a statutory obligation to "...render to the President and to the Congress reports on specific, individual policy matters related to science and engineering and education in science engineering, as Congress or the President determines the need for such reports," (e.g. Science and Engineering Indicators; Report to Congress on Mid-scale Instrumentation at the National Science Foundation). All Board members are presidential appointees. NSF's director serves as an ex officio 25th member and is appointed by the President and confirmed by the US Senate. Mission statement The Board's mission statement states: "Suppor ...
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Tenure
Tenure is a category of academic appointment existing in some countries. A tenured post is an indefinite academic appointment that can be terminated only for cause or under extraordinary circumstances, such as financial exigency or program discontinuation. Tenure is a means of defending the principle of academic freedom, which holds that it is beneficial for society in the long run if scholars are free to hold and examine a variety of views. By country United States and Canada Under the tenure systems adopted by many universities and colleges in the United States and Canada, some faculty positions have tenure and some do not. Typical systems (such as the widely adopted "1940 Statement of Principles on Academic Freedom and Tenure" of the American Association of University Professors) allow only a limited period to establish a record of published research, ability to attract grant funding, academic visibility, teaching excellence, and administrative or community service. They ...
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Science Writer
Science journalism conveys reporting about science to the public. The field typically involves interactions between scientists, journalists, and the public. Origins Modern science journalism dates back to ''Digdarshan'' (means showing the direction) that was an educational monthly magazine started publication in 1818 from Srirampore, Bengal, India. ''Digdarshan'' carried articles on different aspects of science, such as plants, steam boat, etc. It was available in Bengali, Hindi and English languages. One of the occasions an article was attributed to a "scientific correspondent" was "A Gale in the Bay of Biscay" by William Crookes which appeared in ''The Times'' on 18 January 1871, page 7. Thomas Henry Huxley (1825–1895) and John Tyndall (1820–1893) were scientists who were greatly involved in journalism and Peter Chalmers Mitchell (1864–1945) was Scientific Correspondent for ''The Times'' from 1918 to 1935.Gristock, J. (2006"J.G. Crowther, Kuhn and Systems of Mediation ...
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Hang Glider
Hang gliding is an air sport or recreational activity in which a pilot flies a light, non-motorised foot-launched heavier-than-air aircraft called a hang glider. Most modern hang gliders are made of an aluminium alloy or composite frame covered with synthetic sailcloth to form a wing. Typically the pilot is in a harness suspended from the airframe, and controls the aircraft by shifting body weight in opposition to a control frame. Early hang gliders had a low lift-to-drag ratio, so pilots were restricted to gliding down small hills. By the 1980s this ratio significantly improved, and since then pilots have been able to soar for hours, gain thousands of feet of altitude in thermal updrafts, perform aerobatics, and glide cross-country for hundreds of kilometers. The Federation Aeronautique Internationale and national airspace governing organisations control some regulatory aspects of hang gliding. Obtaining the safety benefits of being instructed is highly recommended and indeed a ...
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Antiviral
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit its development. Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Natural viricides are produced by some plants such as eucalyptus and Australian tea trees. Medical uses Most of the antiviral drugs now available are designed to help deal with HIV, herpes viruses, the ...
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United States Department Of Defense
The United States Department of Defense (DoD, USDOD or DOD) is an executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national security and the United States Armed Forces. The DoD is the largest employer in the world, with over 1.34 million active-duty service members (soldiers, marines, sailors, airmen, and guardians) as of June 2022. The DoD also maintains over 778,000 National Guard and reservists, and over 747,000 civilians bringing the total to over 2.87 million employees. Headquartered at the Pentagon in Arlington, Virginia, just outside Washington, D.C., the DoD's stated mission is to provide "the military forces needed to deter war and ensure our nation's security". The Department of Defense is headed by the secretary of defense, a cabinet-level head who reports directly to the president of the United States. Beneath the Department of Defense are th ...
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Protein Folding
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA to a linear chain of amino acids. At this stage the polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding of many proteins begins even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), ...
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Protein Sequence
Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the laboratory. Protein primary structures can be directly sequenced, or inferred from DNA sequences. Formation Biological Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding along it. In biological systems, proteins are produced during translation by a cell's ribosomes. Some organisms can also make short peptides by non-ribosomal peptide synthesis, which often use amino acids other than the standard 20, and may be cyclised, modified and cross-linked. Chemical Peptides can be synthesised chemically via a range of laboratory methods. Chemical methods typically synthesise ...
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Fluorescent Protein
Fluorescent proteins include: * Green fluorescent protein (GFP) * Yellow fluorescent protein (YFP) * Red fluorescent protein Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when excited. Several variants have been developed using directed mutagenesis. The original was isolated from Discosoma, and named DsRed. Others are now available that flu ... (RFP) {{Short pages monitor ...
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Antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few vari ...
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Biotechnology Company
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and ...
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