Stanisław Kostanecki
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Stanisław Kostanecki
Stanisław Kostanecki (born 16 April 1860 in Myszaków, now in Poland then Kingdom of Prussia – 15 November 1910 in Würzburg) was a Polish organic chemist, professor who pioneered in vegetable dye chemistry e.g. curcumin. Known for Kostanecki acylation name reactions. In 1896, he developed the theory of dyes and studied the natural vegetable dyes. Among his many students were famous scientists Kazimierz Funk Kazimierz Funk (; February 23, 1884 – November 19, 1967), commonly anglicized as Casimir Funk, was a Polish-American biochemist generally credited with being among the first to formulate (in 1912) the concept of vitamins, which he called "vita ... and Wiktor Lampe. 1860 births 1910 deaths Polish organic chemists {{Chemist-stub ...
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Myszaków
Myszaków is a village in the administrative district of Gmina Zagórów, within Słupca County, Greater Poland Voivodeship, in west-central Poland. It lies approximately south-west of Zagórów, south of Słupca, and south-east of the regional capital Poznań. One of the battles of the Polish January Uprising against the Russian Empire was fought near the village in 1863. There is a mass grave of the Polish insurgents in the village. Notable people *Stanisław Kostanecki (1860–1910), one of the most renown Polish organic chemists *Kazimierz Kostanecki (1863–1940), Polish physician, anatomist, cytologist, murdered by the Germans in the Sachsenhausen concentration camp * (1866–1941), Polish economist, rector of the University of Warsaw The University of Warsaw ( pl, Uniwersytet Warszawski, la, Universitas Varsoviensis) is a public university in Warsaw, Poland. Established in 1816, it is the largest institution of higher learning in the country offering 37 different fi ...
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Poland
Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populous member state of the European Union. Warsaw is the nation's capital and largest metropolis. Other major cities include Kraków, Wrocław, Łódź, Poznań, Gdańsk, and Szczecin. Poland has a temperate transitional climate and its territory traverses the Central European Plain, extending from Baltic Sea in the north to Sudeten and Carpathian Mountains in the south. The longest Polish river is the Vistula, and Poland's highest point is Mount Rysy, situated in the Tatra mountain range of the Carpathians. The country is bordered by Lithuania and Russia to the northeast, Belarus and Ukraine to the east, Slovakia and the Czech Republic to the south, and Germany to the west. It also shares maritime boundaries with Denmark and Sweden. ...
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Kingdom Of Prussia
The Kingdom of Prussia (german: Königreich Preußen, ) was a German kingdom that constituted the state of Prussia between 1701 and 1918.Marriott, J. A. R., and Charles Grant Robertson. ''The Evolution of Prussia, the Making of an Empire''. Rev. ed. Oxford: Clarendon Press, 1946. It was the driving force behind the unification of Germany in 1871 and was the leading state of the German Empire until its dissolution in 1918. Although it took its name from the region called Prussia, it was based in the Margraviate of Brandenburg. Its capital was Berlin. The kings of Prussia were from the House of Hohenzollern. Brandenburg-Prussia, predecessor of the kingdom, became a military power under Frederick William, Elector of Brandenburg, known as "The Great Elector". As a kingdom, Prussia continued its rise to power, especially during the reign of Frederick II, more commonly known as Frederick the Great, who was the third son of Frederick William I.Horn, D. B. "The Youth of Frederick ...
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Würzburg
Würzburg (; Main-Franconian: ) is a city in the region of Franconia in the north of the German state of Bavaria. Würzburg is the administrative seat of the ''Regierungsbezirk'' Lower Franconia. It spans the banks of the Main River. Würzburg is situated approximately east-southeast of Frankfurt am Main and approximately west-northwest of Nuremberg (). The population (as of 2019) is approximately 130,000 residents. The administration of the ''Landkreis Würzburg'' ( district of Würzburg) is also located in the town. The regional dialect is East Franconian. History Early and medieval history A Bronze Age (Urnfield culture) refuge castle, the Celtic Segodunum,Koch, John T. (2020)CELTO-GERMANIC Later Prehistory and Post-Proto-Indo-European vocabulary in the North and West p. 131 and later a Roman fort, stood on the hill known as the Leistenberg, the site of the present Fortress Marienberg. The former Celtic territory was settled by the Alamanni in the 4th or 5th century ...
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Poles
Poles,, ; singular masculine: ''Polak'', singular feminine: ''Polka'' or Polish people, are a West Slavic nation and ethnic group, who share a common history, culture, the Polish language and are identified with the country of Poland in Central Europe. The preamble to the Constitution of the Republic of Poland defines the Polish nation as comprising all the citizens of Poland, regardless of heritage or ethnicity. The majority of Poles adhere to Roman Catholicism. The population of self-declared Poles in Poland is estimated at 37,394,000 out of an overall population of 38,512,000 (based on the 2011 census), of whom 36,522,000 declared Polish alone. A wide-ranging Polish diaspora (the '' Polonia'') exists throughout Europe, the Americas, and in Australasia. Today, the largest urban concentrations of Poles are within the Warsaw and Silesian metropolitan areas. Ethnic Poles are considered to be the descendants of the ancient West Slavic Lechites and other tribes that inhabi ...
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Chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component atoms. Chemists carefully measure substance proportions, chemical reaction rates, and other chemical properties. In Commonwealth English, pharmacists are often called chemists. Chemists use their knowledge to learn the composition and properties of unfamiliar substances, as well as to reproduce and synthesize large quantities of useful naturally occurring substances and create new artificial substances and useful processes. Chemists may specialize in any number of subdisciplines of chemistry. Materials scientists and metallurgists share much of the same education and skills with chemists. The work of chemists is often related to the ...
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Professor
Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors are usually experts in their field and teachers of the highest rank. In most systems of List of academic ranks, academic ranks, "professor" as an unqualified title refers only to the most senior academic position, sometimes informally known as "full professor". In some countries and institutions, the word "professor" is also used in titles of lower ranks such as associate professor and assistant professor; this is particularly the case in the United States, where the unqualified word is also used colloquially to refer to associate and assistant professors as well. This usage would be considered incorrect among other academic communities. However, the otherwise unqualified title "Professor" designated with a capital let ...
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Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ...
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Curcumin
Curcumin is a bright yellow chemical produced by plants of the ''Curcuma longa'' species. It is the principal curcuminoid of turmeric (''Curcuma longa''), a member of the ginger family, Zingiberaceae. It is sold as a herbal supplement, cosmetics ingredient, food flavoring, and food coloring. Chemically, curcumin is a diarylheptanoid, belonging to the group of curcuminoids, which are natural phenol, phenolic pigments responsible for the yellow color of turmeric. Laboratory and clinical research have not confirmed any medical use for curcumin. It is difficult to study because it is both unstable and poorly bioavailable. It is unlikely to produce useful leads for drug development. History Curcumin was named in 1815 when Henri Auguste Vogel and Pierre Joseph Pelletier reported the first isolation of a "yellow coloring-matter" from the rhizomes of turmeric. Later, it was found to be a mixture of resin and turmeric oil. In 1910, Milobedzka and Lampe reported the chemical structure ...
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Kostanecki Acylation
The Kostanecki acylation is a method used in organic synthesis to form chromones or coumarins by acylation of ''O''-hydroxyaryl ketones with aliphatic acid anhydrides, followed by cyclization. If benzoic anhydride (or benzoyl chloride) is used, a particular type of chromone called a flavone is obtained. Mechanism The mechanism consists of three well-differentiated reactions:Ellis, G. P. (1977) ''Chromenes, Chromanones, and Chromones from The Chemistry of Heterocyclic Compounds'', Weissberger, A. and Taylor, E. C., eds.; Wiley & Sons: New York, vol. 31, p. 495. # Phenol ''O''-acylation with formation of a tetrahedral intermediate # Intramolecular aldol condensation to cyclize and to form a hydroxydihydrochromone # Elimination of the hydroxyl group to form the chromone (or coumarin) Examples * Alvocidib (flavopiridol) * Dimefline *Flavoxate See also * Allan–Robinson reaction * Baker–Venkataraman rearrangement The Baker–Venkataraman rearrangement is the chemical reaction o ...
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Name Reactions
A name reaction is a chemical reaction named after its discoverers or developers. Among the tens of thousands of organic reactions that are known, hundreds of such reactions are well-known enough to be named after people. Well-known examples include the Grignard reaction, the Sabatier reaction, the Wittig reaction, the Claisen condensation, the Friedel-Crafts acylation, and the Diels-Alder reaction. Books have been published devoted exclusively to name reactions;Alfred Hassner, C. Stumer. ''Organic syntheses based on name reactions''. Elsevier, 2002. Li, Jie Jack. ''Name Reactions: A Collection of Detailed Reaction Mechanisms''. Springer, 2003. the Merck Index, a chemical encyclopedia, also includes an appendix on name reactions. As organic chemistry developed during the 20th century, chemists started associating synthetically useful reactions with the names of the discoverers or developers; in many cases, the name is merely a mnemonic. Some cases of reactions that were not reall ...
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Natural Dye
Natural dyes are dyes or colorants derived from plants, invertebrates, or minerals. The majority of natural dyes are vegetable dyes from plant sources—roots, berries, bark, leaves, and wood—and other biological sources such as fungi. Archaeologists have found evidence of textile dyeing dating back to the Neolithic period. In China, dyeing with plants, barks and insects has been traced back more than 5,000 years.Goodwin (1982), p. 11. The essential process of dyeing changed little over time. Typically, the dye material is put in a pot of water and heated to extract the dye compounds into solution with the water. Then the textiles to be dyed are added to the pot, and held at heat until the desired color is achieved. Textile fibre may be dyed before spinning or weaving ("dyed in the wool"), after spinning ("yarn-dyed") or after weaving ("piece-dyed"). Many natural dyes require the use of substances called mordants to bind the dye to the textile fibres. Mordants (from the Latin ver ...
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