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Spiral Ganglion
The spiral (cochlear) ganglion is a group of neuron cell bodies in the modiolus, the conical central axis of the cochlea. These bipolar neurons innervate the hair cells of the organ of Corti. They project their axons to the ventral and dorsal cochlear nuclei as the cochlear nerve, a branch of the vestibulocochlear nerve (CN VIII). Structure Neurons whose cell bodies lie in the spiral ganglion are strung along the bony core of the cochlea, and send fibers (axons) into the central nervous system (CNS). These bipolar neurons are the first neurons in the auditory system to fire an action potential, and supply all of the brain's auditory input. Their dendrites make synaptic contact with the base of hair cells, and their axons are bundled together to form the auditory portion of eighth cranial nerve. The number of neurons in the spiral ganglion is estimated to be about 35,000–50,000. Two apparent subtypes of spiral ganglion cells exist. Type I spiral ganglion cells comprise th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cochlear Duct
The cochlear duct (bounded by the scala media) is an endolymph filled cavity inside the cochlea, located between the tympanic duct and the vestibular duct, separated by the basilar membrane and the vestibular membrane (Reissner's membrane) respectively. The cochlear duct houses the organ of Corti. Structure The cochlear duct is part of the cochlea. It is separated from the tympanic duct (scala tympani) by the basilar membrane. It is separated from the vestibular duct (scala vestibuli) by the vestibular membrane (Reissner's membrane). The stria vascularis is located in the wall of the cochlear duct. Development The cochlear duct develops from the ventral otic vesicle (otocyst). It grows slightly flattened between the middle and outside of the body. This development may be regulated by the genes EYA1, SIX1, GATA3, and TBX1. The organ of Corti develops inside the cochlear duct. Function The cochlear duct contains the organ of Corti. This is attached to the basilar m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dendrites
Dendrites (from Greek δένδρον ''déndron'', "tree"), also dendrons, are branched protoplasmic extensions of a nerve cell that propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons (usually via their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron. Dendritic arborization, also known as dendritic branching, is a multi-step biological process by which neurons form new dendritic trees and branches to create new synapses. The morphology of dendrites such as branch density and grouping patterns are highly correlated to the function of the neuron. Malformation of dendrites is also tightly correlated to impaired nervous sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auditory System
The auditory system is the sensory system for the sense of hearing. It includes both the sensory organs (the ears) and the auditory parts of the sensory system. System overview The outer ear funnels sound vibrations to the eardrum, increasing the sound pressure in the middle frequency range. The middle-ear ossicles further amplify the vibration pressure roughly 20 times. The base of the stapes couples vibrations into the cochlea via the oval window, which vibrates the perilymph liquid (present throughout the inner ear) and causes the round window to bulb out as the oval window bulges in. Vestibular and tympanic ducts are filled with perilymph, and the smaller cochlear duct between them is filled with endolymph, a fluid with a very different ion concentration and voltage. Vestibular duct perilymph vibrations bend organ of Corti outer cells (4 lines) causing prestin to be released in cell tips. This causes the cells to be chemically elongated and shrunk ( somatic motor), and h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of New England, Maine
The University of New England (UNE) is a private research university in Maine with campuses in Portland and Biddeford, as well as a study abroad campus in Tangier, Morocco. During the 2020 academic year, 7,208 students were enrolled in UNE's campus-based and online programs. It traces it historical origins to 1831 when Westbrook Seminary opened on what is now the UNE Portland Campus. UNE is the largest private university in the state of Maine and the largest educator of healthcare professionals for Maine. It is organized into five colleges that combine to offer more than 70 undergraduate, graduate, online, and professional degrees. Known predominantly for its programs in the sciences and health sciences, UNE also offers degrees in the marine sciences, data science, environmental science, mathematics, business, education, the humanities, and many other subjects. Its College of Osteopathic Medicine is the only medical school in Maine and its College of Dental Medicine is the o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ Of Corti
The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transduction occurs through vibrations of structures in the inner ear causing displacement of cochlear fluid and movement of hair cells at the organ of Corti to produce electrochemical signals.The Ear Pujol, R., Irving, S., 2013 Italian anatomist (1822–1876) discovered the organ of Corti in 1851. The structure evolved from the [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brainstem
The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is continuous with the thalamus of the diencephalon through the tentorial notch, and sometimes the diencephalon is included in the brainstem. The brainstem is very small, making up around only 2.6 percent of the brain's total weight. It has the critical roles of regulating cardiac, and respiratory function, helping to control heart rate and breathing rate. It also provides the main motor and sensory nerve supply to the face and neck via the cranial nerves. Ten pairs of cranial nerves come from the brainstem. Other roles include the regulation of the central nervous system and the body's sleep cycle. It is also of prime importance in the conveyance of motor and sensory pathways from the rest of the brain to the body, and from the body bac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vestibular Ganglion
The vestibular ganglion (also called Scarpa's ganglion) is the ganglion of the vestibular nerve. It is located inside the internal auditory meatus. The ganglion contains the cell bodies of Bipolar neuron, bipolar neurons whose peripheral processes form synaptic contact with hair cells of the vestibular system, vestibular sensory end organs. These include hair cells of the cristae ampullares of the semicircular duct and macula in the utricle and saccule. It is named for Antonio Scarpa.A. Scarpa. Anatomicarum annotationum. 2 volumes, Modena and Pavia, 1779, 1785. 2nd edition, Milano, 1792. At birth, it is already close to its final size. References External links Diagram (in French) Vestibulocochlear nerve Vestibular system {{Neuroanatomy-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auditory Vesicle
Otic vesicle, or auditory vesicle, consists of either of the two sac-like invaginations formed and subsequently closed off during embryonic development. It is part of the neural ectoderm, which will develop into the membranous labyrinth of the inner ear. This labyrinth is a continuous epithelium, giving rise to the vestibular system and auditory components of the inner ear. During the earlier stages of embryogenesis, the otic placode invaginates to produce the otic cup. Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ganglion
A ganglion is a group of neuron cell bodies in the peripheral nervous system. In the somatic nervous system this includes dorsal root ganglia and trigeminal ganglia among a few others. In the autonomic nervous system there are both sympathetic and parasympathetic ganglia which contain the cell bodies of postganglionic sympathetic and parasympathetic neurons respectively. A pseudoganglion looks like a ganglion, but only has nerve fibers and has no nerve cell bodies. Structure Ganglia are primarily made up of somata and dendritic structures which are bundled or connected. Ganglia often interconnect with other ganglia to form a complex system of ganglia known as a plexus. Ganglia provide relay points and intermediary connections between different neurological structures in the body, such as the peripheral and central nervous systems. Among vertebrates there are three major groups of ganglia: * Dorsal root ganglia (also known as the spinal ganglia) contain the cell bodies of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudiment (biology)
Vestigiality is the retention, during the process of evolution, of genetically determined structures or attributes that have lost some or all of the ancestral function in a given species. Assessment of the vestigiality must generally rely on comparison with homologous features in related species. The emergence of vestigiality occurs by normal evolutionary processes, typically by loss of function of a feature that is no longer subject to positive selection pressures when it loses its value in a changing environment. The feature may be selected against more urgently when its function becomes definitively harmful, but if the lack of the feature provides no advantage, and its presence provides no disadvantage, the feature may not be phased out by natural selection and persist across species. Examples of vestigial structures (also called degenerate, atrophied, or rudimentary organs) are the loss of functional wings in island-dwelling birds; the human vomeronasal organ; and the hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Outer Hair Cells
Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. In mammals, the auditory hair cells are located within the spiral organ of Corti on the thin basilar membrane in the cochlea of the inner ear. They derive their name from the tufts of stereocilia called ''hair bundles'' that protrude from the apical surface of the cell into the fluid-filled cochlear duct. The stereocilia number from 50-100 in each cell while being tightly packed together and decrease in size the further away they are located from the kinocilium. The hair bundles are arranged as stiff columns that move at their base in response to stimuli applied to the tips. Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inner Hair Cells
Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. In mammals, the auditory hair cells are located within the spiral organ of Corti on the thin basilar membrane in the cochlea of the inner ear. They derive their name from the tufts of stereocilia called ''hair bundles'' that protrude from the apical surface of the cell into the fluid-filled cochlear duct. The stereocilia number from 50-100 in each cell while being tightly packed together and decrease in size the further away they are located from the kinocilium. The hair bundles are arranged as stiff columns that move at their base in response to stimuli applied to the tips. Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
