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Selective Progesterone Receptor Modulators
A selective progesterone receptor modulator (SPRM) is an drug, agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone. A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full receptor antagonist, antagonists (e.g., aglepristone) is that their action differs in different tissue (biology), tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of dissociating undesirable adverse effects from the development of synthetic PR-modulator drug candidates. History Ever since the discovery of the progesterone hormone in the mid-1930s. and especially after the discovery of its receptor in 1970 there has been a significant interest in developing an antagonistic agent for therapeutic use. Various progesterone structural analog, analogs, known ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ulipristal Acetate
Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency contraception (birth control) and uterine fibroids. As emergency contraception it should be used within 120 hours of vaginally penetrating intercourse. For fibroids it may be taken for up to six months. It is taken by mouth. Common side effects include headache, nausea, feeling tired, and abdominal pain. It should not be used in women who are already pregnant. It is in the selective progesterone receptor modulator (SPRM) class of medications. It works by preventing the effects of progesterone, therefore preventing ovulation but not affecting fertilization or implantation. Ulipristal acetate was approved for medical use in the United States in 2010. It is on the World Health Organization's List of Essential Medicines. Medical uses Emergency contraception For emergency contraception a 30 mg tablet is used within 120 hours (5 days) after unprotected intercourse or contr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
