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Sanguinarine
Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose taxonomic name, ''Sanguinaria canadensis,'' its name is drawn; the Mexican prickly poppy (''Argemone mexicana''); ''Chelidonium majus;'' and ''Macleaya cordata.'' Toxicity Sanguinarine is a toxin that kills animal cells through its action on the Na+/K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. If applied to the skin, sanguinarine may cause a massive scab of dead flesh where it killed the cells where it was applied, called an ''eschar''. For this reason, sanguinarine is termed an escharotic. It is said to be 2.5 times more toxic than dihydrosanguinarine. Alternative medicine Native Americans once used sanguinarine in the form of bloodroot as a medical remedy, believing it had curative properties as an emetic, respiratory aid, and for a variety of ailments. In Colonial America, sanguinarine fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sanguinarine Structure V
Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose taxonomic name, ''Sanguinaria canadensis,'' its name is drawn; the Mexican prickly poppy (''Argemone mexicana''); ''Chelidonium majus;'' and '' Macleaya cordata.'' Toxicity Sanguinarine is a toxin that kills animal cells through its action on the Na+/K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. If applied to the skin, sanguinarine may cause a massive scab of dead flesh where it killed the cells where it was applied, called an ''eschar''. For this reason, sanguinarine is termed an escharotic. It is said to be 2.5 times more toxic than dihydrosanguinarine. Alternative medicine Native Americans once used sanguinarine in the form of bloodroot as a medical remedy, believing it had curative properties as an emetic, respiratory aid, and for a variety of ailments. In Colonial America, sanguinarine f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sanguinarine
Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose taxonomic name, ''Sanguinaria canadensis,'' its name is drawn; the Mexican prickly poppy (''Argemone mexicana''); ''Chelidonium majus;'' and ''Macleaya cordata.'' Toxicity Sanguinarine is a toxin that kills animal cells through its action on the Na+/K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. If applied to the skin, sanguinarine may cause a massive scab of dead flesh where it killed the cells where it was applied, called an ''eschar''. For this reason, sanguinarine is termed an escharotic. It is said to be 2.5 times more toxic than dihydrosanguinarine. Alternative medicine Native Americans once used sanguinarine in the form of bloodroot as a medical remedy, believing it had curative properties as an emetic, respiratory aid, and for a variety of ailments. In Colonial America, sanguinarine fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bloodroot
''Sanguinaria canadensis'', bloodroot, is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus ''Sanguinaria'', included in the poppy family Papaveraceae, and is most closely related to '' Eomecon'' of eastern Asia. ''Sanguinaria canadensis'' is sometimes known as Canada puccoon, bloodwort, redroot, red puccoon, and black paste. Plants are variable in leaf and flower shape, and have been separated as a different subspecies due to these variable shapes, indicating a highly variable species. In bloodroot, the juice is red and poisonous. Products made from sanguinaria extracts, such as black salve, are escharotic and can cause permanent disfiguring scarring. Although preliminary studies have suggested that sanguinaria may have potential applications in cancer therapy, clinical studies are lacking, and its use is not recommended. Description Bloodroot grows from tall. It has one large basal leaf, up to across, with five ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidemic Dropsy
Epidemic dropsy is a form of edema of extremities due to poisoning by ''Argemone mexicana'' (Mexican prickly poppy). Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with ''Argemone mexicana'' seed oil. Sanguinarine and dihydrosanguinarine are two major toxic alkaloids of argemone oil, which cause widespread capillary dilatation, proliferation and increased capillary permeability. When mustard oil is adulterated deliberately (as in most cases) or accidentally with argemone oil, proteinuria (specifically loss of albumin) occurs, with a resultant edema as would occur in nephrotic syndrome. Other major symptoms are bilateral pitting edema of extremities, headache, nausea, loose bowels, erythema, glaucoma and breathlessness. Leakage of the protein-rich plasma component into the extracellular compartment leads to the formation of edema. The haemodynamic consequences of this vascular dilatation and permeability lead to a state of relative hypovolem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dihydrosanguinarine
Dihydrosanguinarine is an alkaloid found in the herbs '' Corydalis adunca'' and '' Lamprocapnos spectabilis''. Israilov I, Melikov F, Murav'eva D. Alkaloids of Dicentra. Chem Nat Compd 1984; 20:74–76. See also * Dihydrosanguinarine 10-monooxygenase * Sanguinarine * Epidemic dropsy Epidemic dropsy is a form of edema of extremities due to poisoning by ''Argemone mexicana'' (Mexican prickly poppy). Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with ''Argemone mexicana'' seed oil. Sanguin ... References Benzodioxoles Isoquinoline alkaloids Quinoline alkaloids {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chelidonium Majus
''Chelidonium majus'', the greater celandine, is a perennial herbaceous flowering plant in the poppy family Papaveraceae. One of two species in the genus ''Chelidonium'', it is native to Europe and western Asia and introduced widely in North America. The plant known as lesser celandine ('' Ficaria verna'') is not closely related, as it belongs to the buttercup family Ranunculaceae. Description Greater celandine is a perennial herbaceous plant with an erect habit, and reaches high. The blue-green leaves are pinnate with lobed and wavy margins, up to long. When injured, the plant exudes a yellow to orange latex. The flowers consist of four yellow petals, each about long, with two sepals. A double-flowered variety occurs naturally. The flowers appear from late spring to summer, May to September (in the UK), in umbelliform cymes of about 4 flowers. The seeds are small and black, borne in a long, cylindrical capsule. Each has an elaiosome, which attracts ants to disperse the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Argemone Mexicana
''Argemone mexicana'' (Mexican poppy, Mexican prickly poppy, flowering thistle, cardo or cardosanto) is a species of poppy found in Mexico and now widely naturalized in many parts of the world. An extremely hardy pioneer plant, it is tolerant of drought and poor soil, often being the only cover on new road cuttings or verges. It has bright yellow latex. It is poisonous to grazing animals, and it is rarely eaten, but it has been used medicinally by many peoples, including those in its native area, as well as the Natives of the western US, parts of Mexico and many parts of India. In India, during the colorful festival Holika Dahan, adults and children worship by offering flowers, and this species is in its maximum flowering phase during March when the Holi festival is celebrated. It is also referred to as "kateli ka phool” in India. Chemical constituents ''Argemone mexicana'' seeds contain 22–36% of a pale yellow non-edible oil, called ''argemone oil'' or ''katkar oil'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dihydrobenzophenanthridine Oxidase
Dihydrobenzophenanthridine oxidase (DHBP oxidase) is an enzyme. In the IUBMB Enzyme Nomenclature, dihydrobenzophenanthridine oxidase is . Dihydrobenzophenanthridine oxidase produces oxidized forms of benzophenanthridine alkaloids: * In ''Sanguinaria canadensis'' (bloodroot), dihydrobenzophenanthridine oxidase produces sanguinarine from dihydrosanguinarine, and chelirubine from dihydrochelirubine. * In ''Eschscholzia californica ''Eschscholzia californica'', the California poppy, golden poppy, California sunlight or cup of gold, is a species of flowering plant in the family Papaveraceae, native to the United States and Mexico. It is cultivated as an ornamental plant ...'' (California poppy), dihydrobenzophenanthridine oxidase produces macarpine from dihydromacarpine. External links Chelirubine, Macarpine and Sanguinarine Biosynthesis* * * KEGG (Kyoto Encyclopedia of Genes and Genomes) Alkaloid biosynthesis I - Reference pathway EC 1.5.3 {{1.5-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eschar
An eschar (; Greek: ''ἐσχάρᾱ'', ''eskhara''; Latin: ''eschara'') is a slough or piece of dead tissue that is cast off from the surface of the skin, particularly after a burn injury, but also seen in gangrene, ulcer, fungal infections, necrotizing spider bite wounds, tick bites associated with spotted fevers and exposure to cutaneous anthrax. The term ‘eschar’ is not interchangeable with ‘scab’. An eschar contains necrotic tissue whereas a scab is composed of dried blood and exudate. Black eschars are most frequently attributed in medicine to cutaneous anthrax (infection by ''Bacillus anthracis''), which may be contracted through herd animal exposure and also from '' Pasteurella multocida'' exposure in cats and rabbits. A newly identified human rickettsial infection, ''R. parkeri'' rickettsiosis, can be differentiated from Rocky Mountain spotted fever by the presence of an eschar at the site of inoculation. Eschar is sometimes called a ''black wound'' becau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escharotic
An eschar (; Greek: ''ἐσχάρᾱ'', ''eskhara''; Latin: ''eschara'') is a slough or piece of dead tissue that is cast off from the surface of the skin, particularly after a burn injury, but also seen in gangrene, ulcer, fungal infections, necrotizing spider bite wounds, tick bites associated with spotted fevers and exposure to cutaneous anthrax. The term ‘eschar’ is not interchangeable with ‘scab’. An eschar contains necrotic tissue whereas a scab is composed of dried blood and exudate. Black eschars are most frequently attributed in medicine to cutaneous anthrax (infection by ''Bacillus anthracis''), which may be contracted through herd animal exposure and also from ''Pasteurella multocida'' exposure in cats and rabbits. A newly identified human rickettsial infection, ''R. parkeri'' rickettsiosis, can be differentiated from Rocky Mountain spotted fever by the presence of an eschar at the site of inoculation. Eschar is sometimes called a ''black wound'' because t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chelidonine
Chelidonine is an isolate of ''Papaveraceae'' with acetylcholinesterase and butyrylcholinesterase inhibitory activity. Introduction Chelidonine is the major alkaloid component of '' Chelidonium majus''. ''Chelidonium majus L''. is the only species of the tribe Chelidonieae of the family Papaveraceae. Papaveraceae is rich in specific alkaloids. ''C. majus'' contains various isoquinoline alkaloids with protopine, protoberberine and benzophenanthridine structures. This benzophenanthridine alkaloid can induce apoptosis in some transformed or malignant cell lines. D-Chelidonine, the main alkaloid of ''Chelidonium majus'', was first isolated in 1839.Keller, K. (1971). Total synthesis of dl-chelidonine. ''Journal of the American Chemical Society'', ''117''(51), 3836. The supposed healing properties of greater celandine (''Chelidonium majus'') were believed in throughout Europe and Asia during the Imperial Roman period (Pliny 1966), and New World aboriginal cultures used BIA-containing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids Found In Papaveraceae
Alkaloids are a class of base (chemistry), basic, natural product, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including bacteria, fungus, fungi, Medicinal plant, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
