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Sanaria
Sanaria is a biotechnology company developing vaccines protective against malaria and other infectious diseases as well as related products for use in malaria research. Sanaria's vaccines are based on the use of the sporozoite, sporozoite (SPZ) stage of the malaria parasite, ''Plasmodium,'' as an immunogen, and as a platform technology for liver-vectored gene delivery. SPZ are normally introduced into humans by mosquito bite where they migrate to the liver and further develop to liver stages, and eventually back into the blood stream where the parasite infects red blood cells (RBC) and causes malaria. ''Plasmodium falciparum'' is the species responsible for more than 95% deaths caused by malaria. The WHO estimates there were 249 million clinical cases and 608,000 deaths in 2022 alone. Sanaria has developed the technology to grow and harvest aseptic, purified ''Plasmodium falciparum'' (Pf) SPZ and formulate them as vaccines for human use. Sanaria's first generation vaccine is cal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PfSPZ Vaccine
PfSPZ Vaccine is a metabolically active non-replicating whole sporozoite (SPZ) malaria vaccine being developed by Sanaria against ''Plasmodium falciparum'' (Pf) malaria. Clinical trials have been safe, extremely well tolerated and highly efficacious. The first generation PfSPZ product is attenuated by gamma irradiation; the second generation vaccines PfSPZ-CVac and PfSPZ LARC2 are, respectively, attenuated chemically and genetically. Multiple studies are ongoing with trials of the PfSPZ vaccines. All three products are produced using the same manufacturing process. These products are stored and distributed below -150 °C using liquid nitrogen (LN2) vapor phase (LNVP) freezers and Dry shipper, cryoshippers. History In the first half of the 20th century there were first attempts to protect people from malaria. At the beginning Pasteur's approach of developing bacterial vaccines was used as a big hope in eradication of this fatal disease. But inactivated malaria sporozoites (by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |