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Syntex Corporation
Laboratorios Syntex SA (later Syntex Laboratories, Inc.) was a pharmaceutical company formed in Mexico City in January 1944 by Russell Marker, Emeric Somlo, and Federico Lehmann to manufacture therapeutic steroids from the Mexican yams called ''cabeza de negro'' (''Dioscorea mexicana'') and ''Barbasco'' (''Dioscorea composita''). The demand for barbasco by Syntex initiated the Mexican barbasco trade. As the American Chemistry Society later explained: “In early 1944, the new Mexican company was chartered and named Syntex, S.A. (‘Synthesis and Mexico’). Russell Marker, shortly thereafter, left Syntex on account of his ruthless cofounder. Luis E. Miramontes, George Rosenkranz and Carl Djerassi's successful synthesis of norethindrone (also known as norethindrone) — which was later proven to be an effective pregnancy inhibitor — led to an infusion of capital into Syntex and the Mexican steroid pharmaceutical industry. George Rosenkranz and Carl Djerassi went on to synthesize ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mexico City
Mexico City ( es, link=no, Ciudad de México, ; abbr.: CDMX; Nahuatl: ''Altepetl Mexico'') is the capital and largest city of Mexico, and the most populous city in North America. One of the world's alpha cities, it is located in the Valley of Mexico within the high Mexican central plateau, at an altitude of . The city has 16 boroughs or ''demarcaciones territoriales'', which are in turn divided into neighborhoods or ''colonias''. The 2020 population for the city proper was 9,209,944, with a land area of . According to the most recent definition agreed upon by the federal and state governments, the population of Greater Mexico City is 21,804,515, which makes it the sixth-largest metropolitan area in the world, the second-largest urban agglomeration in the Western Hemisphere (behind São Paulo, Brazil), and the largest Spanish language, Spanish-speaking city (city proper) in the world. Greater Mexico City has a gross domestic product, GDP of $411 billion in 2011, which makes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Government Of Mexico
The Federal government of Mexico (alternately known as the Government of the Republic or ' or ') is the national government of the Mexico, United Mexican States, the central government established by its constitution to share sovereignty over the republic with the governments of the 31 individual Mexican states, and to represent such governments before international bodies such as the United Nations. The Mexican federal government has three branches: executive, legislative, and judicial and functions per the Constitution of Mexico, Constitution of the United Mexican States, as enacted in 1917, and as amended. The executive power is exercised by the executive branch, which is headed by the president and his Cabinet of Mexico, Cabinet, which, together, are independent of the legislature. Legislative power is vested upon the Congress of Mexico, Congress of the Union, a bicameral legislature comprising the Senate of Mexico, Senate and the Chamber of Deputies of Mexico, Chamber of Deput ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Noretynodrel
Noretynodrel, or norethynodrel, sold under the brand name Enovid among others, is a progestin medication which was previously used in birth control pills and in the treatment of gynecological disorders but is now no longer marketed. It was available both alone and in combination with an estrogen. The medication is taken by mouth. Noretynodrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It is a relatively weak progestogen. The medication has weak estrogenic activity, no or only very weak androgenic activity, and no other important hormonal activity. It is a prodrug of various active metabolites in the body, such as norethisterone among others. Noretynodrel was introduced for medical use in 1957. It was specifically approved at this time in combination with mestranol for the treatment of gynecological and menstrual disorders. Subsequently, in 1960, this formulation was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madison, Wisconsin
Madison is the county seat of Dane County and the capital city of the U.S. state of Wisconsin. As of the 2020 census the population was 269,840, making it the second-largest city in Wisconsin by population, after Milwaukee, and the 80th-largest in the U.S. The city forms the core of the Madison Metropolitan Area which includes Dane County and neighboring Iowa, Green, and Columbia counties for a population of 680,796. Madison is named for American Founding Father and President James Madison. The city is located on the traditional land of the Ho-Chunk, and the Madison area is known as ''Dejope'', meaning "four lakes", or ''Taychopera'', meaning "land of the four lakes", in the Ho-Chunk language. Located on an isthmus and lands surrounding four lakes—Lake Mendota, Lake Monona, Lake Kegonsa and Lake Waubesa—the city is home to the University of Wisconsin–Madison, the Wisconsin State Capitol, the Overture Center for the Arts, and the Henry Vilas Zoo. Madison is ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ralph Dorfman
Ralph Isadore Dorfman, (1911 – November 19, 1985) was a Jewish American biochemist. His work on metabolism in pharmacology and the use of steroid hormones contributed to the development of the combined oral contraceptive pill."Dr. Ralph I. Dorfman" '''', December 12, 1985, accessed February 5, 2019 Dorfman was born in Chicago, Illinois.Simoni, Robert D., Robert L. Hill, Martha Vaughan and Herbert Tabor "The Metabolism of Steroid Hormones: Ralph I. Dorfm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jerzy Rzedowski
Jerzy Rzedowski Rotter (born December 27, 1926) is a Mexican botanist. His focus is on Mexican floristics, taxonomy, and ecology. Education and personal life He was born in Lwów, Poland (now in Ukraine) to Arnold and Ernestyna (nee Rotter) Rzedowski. When he was young the family was imprisoned in a concentration camp until World War II ended, when he and his father were liberated by the Allies. They then travelled to Mexico in 1946 for a new life. He studied for a bachelor's degree in Biology at the Instituto Politecnico Nacional, starting in 1949, and a PhD in Botany at Universidad Nacional Autónoma de México awarded in 1961. His bachelor's thesis, on the Flora of the Pedregal de San Angel, (''Vegetación del Pedregal de San Angel, Distrito Federal, Mexico'') and doctoral thesis (''Vegetación del Estado de San Luis Potosi'') led to his scientific research career. In 1954 Rzedowski married Graciela Calderón Díaz-Barriga. Career He worked at Syntex in 1953. From 1954 to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Combined Oral Contraceptive Pill
The combined oral contraceptive pill (COCP), often referred to as the birth control pill or colloquially as "the pill", is a type of birth control that is designed to be taken orally by women. The pill contains two important hormones: progestin (a synthetic form of the hormone progestogen/progesterone) and estrogen (usually ethinylestradiol and 17β estradiol). When taken correctly, it alters the menstrual cycle to eliminate ovulation and prevent pregnancy. COCPs were first approved for contraceptive use in the United States in 1960, and are a very popular form of birth control. They are used by more than 100 million women worldwide and by about 9 million women in the United States. From 2015 to 2017, 12.6% of women aged 15–49 in the US reported using COCPs, making it the second most common method of contraception in this age range (female sterilization is the most common method). Use of COCPs, however, varies widely by country, age, education, and marital status. For exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progestin
A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural product, natural female sex hormone progesterone in the body. A progestin is a ''synthetic compound, synthetic'' progestogen. Progestogens are used most commonly in hormonal contraception, hormonal birth control and menopausal hormone therapy. They can also be used in the treatment of gynecological conditions, to support fertility and pregnancy, to lower sex hormone levels for various purposes, and for other indications. Progestogens are used alone or in combination with estrogen (medication), estrogens. They are available in a wide variety of drug formulation, formulations and for use by many different route of administration, routes of administration. Examples of progestogens include natural or bioidentical progesterone (medication), progesterone as well as progestins such as medroxyprogesterone acetate and norethisterone. Side ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNAM
The National Autonomous University of Mexico ( es, Universidad Nacional Autónoma de México, UNAM) is a public research university in Mexico. It is consistently ranked as one of the best universities in Latin America, where it's also the biggest in terms of enrollment. A portion of UNAM's main campus in Mexico City, known as '' Ciudad Universitaria'' (University City), is a UNESCO World Heritage site that was designed by some of Mexico's best-known architects of the 20th century and hosted the 1968 Summer Olympic Games. Murals in the main campus were painted by some of the most recognized artists in Mexican history, such as Diego Rivera and David Alfaro Siqueiros. With acceptance rates usually below 10%, and its research, especially in Artificial Intelligence, being recognized by UNESCO as one of the most impactful globally, UNAM is known for its high quality research and educational level. All Mexican Nobel laureates are either alumni or faculty of UNAM. UNAM was founded, in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alejandro Zaffaroni
Alejandro Zaffaroni (February 27, 1923 – March 1, 2014) was a Uruguayan serial entrepreneur who was responsible for founding several biotechnology companies in Silicon Valley. Products that he was involved in developing include the birth control pill, the nicotine patch, corticosteroids, and the DNA microarray. Education Zaffaroni was born on February 27, 1923 in Montevideo. Zaffaroni was of Italian descent, as his grandfather migrated from Italy to Uruguay at the age of 16. Both of Zaffaroni's parents passed away early in his life; his mother when he was 12 and his father when he was 18. His father was in the banking business. Zaffaroni received his Bachelor of Science degree from the University of the Republic in 1945, and his Ph.D. in biochemistry from the University of Rochester in 1949. Career Zaffaroni joined Syntex, then a small chemical company in Mexico, as a biochemist in 1951. He participated in turning Syntex into a major multinational pharmaceutical company, movi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Russell Earl Marker
Russell Earl Marker (March 12, 1902 – March 3, 1995) was an American chemist who invented the octane rating system when he was working at the Ethyl Corporation. Later in his career, he went on to found a steroid industry in Mexico when he successfully made semisynthetic progesterone from chemical constituents found in Mexican yams in a process known as Marker degradation. This eventually led to the development at Syntex of the combined oral contraceptive pill and synthetic cortisone – and to the development of the Mexican barbasco trade. Biography He was born on March 12, 1902, in Hagerstown, Maryland. He received his B.S. in 1923 from the University of Maryland and an M.S. in physical chemistry in 1924 from the same institution. In 1926, he married Mildred Collins (1899–1985) and worked as an analytical chemist at the Naval Powder Factory in Indian Head, Maryland. He then began work at the Ethyl Corporation where he came up with the concept of the octane rating. In 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VMware
VMware, Inc. is an American cloud computing and virtualization technology company with headquarters in Palo Alto, California. VMware was the first commercially successful company to virtualize the x86 architecture. VMware's desktop software runs on Microsoft Windows, Linux, and macOS. VMware ESXi, its enterprise software hypervisor, is an operating system that runs on server hardware. In May 2022, Broadcom Inc. announced an agreement to acquire VMware in a cash-and-stock transaction valued at $61 billion. History Early history In 1998, VMware was founded by Diane Greene, Mendel Rosenblum, Scott Devine, Ellen Wang and Edouard Bugnion. Greene and Rosenblum were both graduate students at the University of California, Berkeley. Edouard Bugnion remained the chief architect and CTO of VMware until 2005, and went on to found Nuova Systems (now part of Cisco). For the first year, VMware operated in stealth mode, with roughly 20 employees by the end of 1998. The company was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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