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Syncytin-2
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene. This protein plays a key role in the implantation of human embryos in the womb. This gene is conserved among all primates, with an estimated age of 45 million years. The receptor for this fusogenic ''env'' protein is MFSD2. The mouse syncytins are not true orthologues. The virus, along with some very similar insertions, belong to a group under the ''Gammaretrovirus''-like class I ERVs. Similar ERVs are found in artiodactyl The even-toed ungulates (Artiodactyla , ) are ungulates—hoofed animals—which bear weight equally on two (an even number) of their five toes: the third and fourth. The other three toes are either present, absent, vestigial, or pointing poster ...s, a result of an independent integration event. A proposed nomenclature suggests putting all such "class I" elements in a genus-level taxon separate from ''Gammaretrovirus''. Reference ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Env (gene)
''Env'' is a viral gene that encodes the protein forming the viral envelope. The expression of the ''env'' gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane. Analysis of the structure and sequence of several different ''env'' genes suggests that Env proteins are type 1 fusion machines. Type 1 fusion machines initially bind a receptor on the target cell surface, which triggers a conformational change, allowing for binding of the fusion protein. The fusion peptide inserts itself in the host cell membrane and brings the host cell membrane very close to the viral membrane to facilitate membrane fusion. While there are significant differences in sequence of the ''env'' gene between retroviruses, the gene is always located downstream of ''gag'', ''pro'', and '' pol''. The ''env'' mRNA must be spliced for expression. The mature product of the ''env'' gene is the viral spike protein, which has two main parts: the surface pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFSD2
Major facilitator superfamily domain-containing protein 2 (MFSD2 or MFSD2A) -- also known as sodium-dependent lysophosphatidylcholine symporter 1 -- is a protein that in humans is encoded by the ''MFSD2A'' gene. MFSD2A is a membrane transport protein that is expressed in the endothelium of the blood–brain barrier (BBB) and has an essential role in BBB formation and function. Genetic ablation of MFSD2A results in leaky BBB and increases central nervous system endothelial cell vesicular transcytosis without otherwise affecting tight junctions. * MFSD2A is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to AMTF8. In addition to transport of other lysophosphatidylcholines across the BBB, MSFD2A is the primary mechanism for docosahexaenoic acid (DHA, an omega-3 fatty acid Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or ''n''−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a doub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artiodactyl
The even-toed ungulates (Artiodactyla , ) are ungulates—hoofed animals—which bear weight equally on two (an even number) of their five toes: the third and fourth. The other three toes are either present, absent, vestigial, or pointing posteriorly. By contrast, odd-toed ungulates bear weight on an odd number of the five toes. Another difference between the two is that many other even-toed ungulates (with the exception of Suina) digest plant cellulose in one or more stomach chambers rather than in their intestine as the odd-toed ungulates do. Cetaceans (whales, dolphins, and porpoises) evolved from even-toed ungulates, and are therefore often classified under the same taxonomic branch because a species cannot outgrow its evolutionary ancestry; some modern taxonomists combine the two under the name Cetartiodactyla , while others opt to include cetaceans in the already-existing Artiodactyla. The roughly 270 land-based even-toed ungulate species include pigs, peccaries, hippopota ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
