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Sulfoxone
Sulfoxone or aldesulfone sodium is an anti-leprosy drug. It is also known as diasone. Sulfoxone sodium was introduced in Japan in 1948. Ernest Muir introduced it to Western use while serving as superintendent of the Chacachacare Leprosarium on Trinidad in the Caribbean The Caribbean (, ) ( es, El Caribe; french: la Caraïbe; ht, Karayib; nl, De Caraïben) is a region of the Americas that consists of the Caribbean Sea, its islands (some surrounded by the Caribbean Sea and some bordering both the Caribbean Se ..... References {{Nucleic acid inhibitors Anilines Sulfonamides Antileprotic drugs Sulfonamide antibiotics Organic sodium salts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antileprotic Drugs
A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy. The following agents are leprostatic agents: * acedapsone * clofazimine * dapsone * desoxyfructo-serotonin * diucifon * ethionamide * rifampicin * rifapentine * sulfameter * thalidomide Leprosy is a chronic infectious disease caused by ''Mycobacterium leprae''. Host defenses are crucial in determining the patient's response to the disease, the clinical presentation, and the bacillary load. These factors also influence the length of therapy and the risk of adverse reactions to medication. ''M. leprae'' cannot be grown on routine laboratory culture media, so drug sensitivity testing in vitro is not possible. Growth and drug susceptibility testing are done by injecting into animal models. One description of a clinical picture that results from tuberculoid leprosy is characterized by intact cell-mediated immunity, a positive lepromin skin reaction, granuloma formation, and a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the quadrant (anatomy), right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm. Its other roles in metabolism include the regulation of Glycogen, glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the fatty acid degradation, breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized biological tissue, tissue, consisting mostly of hepatocytes, regulates a w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leprosy
Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria ''Mycobacterium leprae'' or ''Mycobacterium lepromatosis''. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This nerve damage may result in a lack of ability to feel pain, which can lead to the loss of parts of a person's extremities from repeated injuries or infection through unnoticed wounds. An infected person may also experience muscle weakness and poor eyesight. Leprosy symptoms may begin within one year, but, for some people, symptoms may take 20 years or more to occur. Leprosy is spread between people, although extensive contact is necessary. Leprosy has a low pathogenicity, and 95% of people who contract ''M. leprae'' do not develop the disease. Spread is thought to occur through a cough or contact with fluid from the nose of a person infected by leprosy. Genetic factors and immune function play a role in how easily a person catches the disease. Lepro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Muir (leprologist)
Ernest Muir (17 June 1880 – 1 November 1974) was a Scottish medical missionary and educator in British-controlled India and Nigeria most noted for his work with Hansen's disease (leprosy). Life Ernest Muir was born in Banffshire, Scotland on 17 June 1880. He studied at Watson's College and the University Medical School in Edinburgh. In 1903, he began work as a medical missionary for the Edinburgh Medical Missionary Association in Tiberias. Tiberias was then part of the Ottoman Acre Sanjak, and later part of Israel. Muir returned to Scotland to complete the clinical aspects of his medical doctorate and then left for Bengal in British-controlled India in 1908, where he worked on tropical diseases, completing his degree with a thesis on visceral leishmaniasis ("kala-azar") in 1910. He completed the requirements for joining the Fellowship of the Royal Colleges of Surgeons while on leave in Scotland in 1914. In 1920, Leonard Rogers invited him to come to Calcutta (now ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chacachacare Leprosarium
Chacachacare is an island in the Republic of Trinidad and Tobago, located at 10° 41' north latitude and 61° 45' west longitude. The island is in area. It is one of the Bocas Islands, which lie in the ''Bocas del Dragón'' (''Dragons' Mouth'') between Trinidad and Venezuela. Chacachacare is the westernmost of the Bocas Islands which belong to Trinidad and Tobago. Patos Island, which lies further west, was part of Trinidad and Tobago until 1942, when it was ceded to Venezuela in exchange for Soldado Rock. History The island was spotted by Christopher Columbus on his third New World voyage on 12 August 1498, and his little fleet spent the night anchored in Monkey Harbour. He named the island 'Port of Cats' because he heard roars of what he thought were wildcats, mistaking the call of howler monkeys for wildcats. It has also been called "El Caracol" (the Snail) because of its shape. At various times in its history Chacachacare has served as a cotton plantation, a whal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Trinidad
The history of Trinidad and Tobago begins with the settlements of the islands by Indigenous First Peoples. Trinidad was visited by Christopher Columbus on his third voyage in 1498, (he never landed in Tobago), and claimed in the name of Spain. Trinidad was administered by Spanish hands until 1797, but it was largely settled by French colonists. Tobago changed hands between the British, French, Dutch, and Courlanders, but eventually ended up in British hands following the second Treaty of Paris (1814). In 1889, the two islands were incorporated into a single political entity. Trinidad and Tobago obtained its independence from the British Empire in 1962 and became a republic in 1976. Pre-Columbian period Human settlement in Trinidad dates back at least 7,000 years. The earliest settlers, termed Archaic or Ortoiroid, are believed to have settled Trinidad and Tobago from northeastern South America around 4000 BCE. Twenty-nine Archaic sites have been identified, mostly in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caribbean Islands
Almost all of the Caribbean islands are in the Caribbean Sea, with only a few in inland lakes. The largest island is Cuba. Other sizable islands include Hispaniola, Jamaica, Puerto Rico and Trinidad and Tobago. Some of the smaller islands are referred to as a ''rock'' or ''reef.'' ''Islands are listed in alphabetical order by country of ownership and/or those with full independence and autonomy. Islands with coordinates can be seen on the map linked to the right.'' Antigua and Barbuda There are 54 islands in Antigua and Barbuda. There are three main islands, the two populated islands (Antigua and Barbuda) and Redonda. There are 51 off-shore islands. The islands of the country of Antigua and Barbuda include: *Antigua, , * Northeast Marine Management Area ** Prickly Pear Island ** Great Bird Island ** Galley Island Major ** Galley Island Minor ** Jenny Island ** Exchange Island ** Rabbit Island ** Lobster Island ** Long Island ** Maiden Island ** Rat Island ** Little ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bauru
Bauru () is a Brazilian municipality in midwestern region of the state of São Paulo. It is the main city of the mesoregion and microregion of Bauru. The population is 379,297 (2020 est.) in an area of 667.68 km². Established in 1896, its boundaries are Reginópolis to the north, Arealva to the northeast, Pederneiras to the east, Agudos and Piratininga to the south and Avaí to the west. The presence of a strong service sector, many college campuses - including the University of São Paulo and Universidade Estadual Paulista - and the city's location at the junction of three railroads and three highways make Bauru a major urban center of the State of São Paulo. It is the hometown of Marcos César Pontes, the first Brazilian in space. It is also the town where Pelé grew up and learned his football skills. The city is served by two airports: the older Comte. João Ribeiro de Barros Airport and the newer Bauru-Arealva Airport, officially known as Moussa Nakhl Tobias A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamides
In organic chemistry, the sulfonamide functional group (also spelled sulphonamide) is an organosulfur group with the structure . It consists of a sulfonyl group () connected to an amine group (). Relatively speaking this group is unreactive. Because of the rigidity of the functional group, sulfonamides are typically crystalline; for this reason, the formation of a sulfonamide is a classic method to convert an amine into a crystalline derivative which can be identified by its melting point. Many important drugs contain the sulfonamide group. A sulfonamide (compound) is a chemical compound that contains this group. The general formula is or , where each R is some organic group; for example, "methanesulfonamide" (where R = methane, R' = R" = hydrogen) is . Any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group () with an amine group. In medicine, the term "sulfonamide" is sometimes used as a synonym for sulfa drug, a derivative or var ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide Antibiotics
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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