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Sudhir Kumar Sopory
Sudhir Kumar Sopory (born 7 January 1948) is an Indian educationist, plant physiologist, scientist and former vice chancellor of Jawaharlal Nehru University, New Delhi. He is known to be the first to purify a protein kinase C activity from plants and is credited with the identification of topoisomerase as a substrate of protein kinase C. He is an elected Fellow of several major Indian science academies and The World Academy of Sciences (TWAS) and is a recipient of many honours, including the 1987 Shanti Swarup Bhatangar Prize, the highest Indian award in the science and technology categories. The Government of India awarded him the fourth highest civilian honour of the Padma Shri, in 2007, for his contributions to science and technology. Biography Born on 7 January 1948, Sopory secured his graduate degree (BSc) in 1966 and postgraduate degree (MSc) in 1968 from Sri Pratap College, Sri Nagar of the University of Kashmir. Subsequently, he moved to Delhi to start his career by jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ambala, Haryana
Ambala () is a city and a municipal corporation in Ambala district in the state of Haryana, India, located on the border with the Indian state of Punjab and in proximity to both states capital Chandigarh. Politically, Ambala has two sub-areas: Ambala Cantonment (also known as Ambala Cantt) and Ambala City, eight kilometres apart, therefore it is also known as "Twin City". It has a large Indian Army and Indian Air Force presence within its cantonment area. It is located 200 km (124 mi) to the north of New Delhi, India's capital, and has been identified as a counter-magnet city for the National Capital Region to develop as an alternative center of growth to Delhi. Ambala separates the Ganges river network from the Indus river network and is surrounded by two rivers – Ghaggar and Tangri – to the north and to the south. Due to its geographical location, the Ambala district plays an important role in local tourism, being located south of Chandigarh, no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Planck Institute For Plant Breeding Research
The Max Planck Institute for Plant Breeding Research was founded in Müncheberg, Germany in 1928 as part of the Kaiser-Wilhelm-Gesellschaft. The founding director, Erwin Baur, initiated breeding programmes with fruits and berries, and basic research on ''Antirrhinum majus'' and the domestication of lupins. After the Second World War, the institute moved west to Voldagsen, and was relocated to new buildings on the present site in Cologne in 1955. ·The modern era of the Institute began in 1978 with the appointment of Jeff Schell and the development of plant transformation technologies and plant molecular genetics. The focus on molecular genetics was extended in 1980 with the appointment of Heinz Saedler. The appointment in 1983 of Klaus Hahlbrock broadened the expertise of the Institute in the area of plant biochemistry, and the arrival of Francesco Salamini in 1985 added a focus on crop genetics. During the period 1978-1990, the Institute was greatly expanded and new buildings we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith (chemist), Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of Ancient DNA, ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Regulation
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Although as early as 1951, Barbara McClintock showed interaction between two genetic loci, Activator (''Ac'') and Dissociator (''Ds''), in the color formation of maize seeds, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topoisomerase I
DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms, linked (catenated) and unlinked species, and knotted and unknotted DNA. Topological issues in DNA arise due to the intertwined nature of its double-helical structure, which, for example, can lead to overwinding of the DNA duplex during DNA replication and transcription. If left unchanged, this torsion would eventually stop the DNA or RNA polymerases involved in these processes from continuing along the DNA helix. A second topological challenge results from the linking or tangling of DNA during replication. Left unresolved, links between replicated DNA will impede cell division. The DNA topoisomerases prevent and correct these types of topological problems. They do this by binding to DNA and cutting the sugar-phosphate backbone of either one (type I topoisomerases) or both (type II topoisomerases) of the DNA strands. This transien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase C
In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. In biochemistry, the PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transduction (genetics)
Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector. An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. Transduction does not require physical contact between the cell donating the DNA and the cell receiving the DNA (which occurs in conjugation), and it is DNase resistant (transformation is susceptible to DNase). Transduction is a common tool used by molecular biologists to stably introduce a foreign gene into a host cell's genome (both bacterial and mammalian cells). Discovery (bacterial transduction) Transduction was discovered by Norton Zinder and Joshua Lederberg at the University of Wisconsin–Madison in 1952 in Salmonella. In the lytic and lysogenic cycles Transduction happens through either the lytic cycle or the lysogenic cycle. When bacteriophages (viruses that infect bacteria) that are lytic infect bacterial cells, they harness the replicationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphoinositide
Phosphatidylinositol (or Inositol Phospholipid) consists of a family of lipids as illustrated on the right, where red is x, blue is y, and black is z, in the context of independent variation, a class of the phosphatidylglycerides. In such molecules the isomer of the inositol group is assumed to be the myo- conformer unless otherwise stated. Typically phosphatidylinositols form a minor component on the cytosolic side of eukaryotic cell membranes. The phosphate group gives the molecules a negative charge at physiological pH. The form of phosphatidylinositol comprising the isomer ''muco''-inositol acts as a sensory receptor in the taste function of the sensory system. In this context it is often referred to as PtdIns, but that does not imply any molecular difference from phosphatidylinositols comprising the myo- conformers of inositol. The phosphatidylinositol can be phosphorylated to form phosphatidylinositol phosphate (PI-4-P, referred to as PIP in close context or informal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reductase
A reductase is an enzyme that catalyzes a reduction reaction. Examples * 5α-Reductase * 5β-Reductase * Dihydrofolate reductase * HMG-CoA reductase * Methemoglobin reductase * Ribonucleotide reductase * Thioredoxin reductase * ''E. coli'' nitroreductase * Methylenetetrahydrofolate reductase See also * Oxidase * Oxidoreductase In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually u ... References Oxidoreductases {{Enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D1 Protein
D1, D01, D.I, D.1 or D-1 can refer to: Science and technology Biochemistry and medicine * ATC code D01 ''Antifungals for dermatological use'', a subgroup of the Anatomical Therapeutic Chemical Classification System * Dopamine receptor D1, a protein * Haplogroup D1 (Y-DNA) * Vitamin D1, a form of Vitamin D * DI, Iodothyronine deiodinase type I, an enzyme involved with thyroid hormones Technology * Nikon D1, a digital single-lens reflex camera * D1, former brand of T-Mobile in Germany * D1, an abbreviation for DOCSIS 1.0 1.0, an international telecommunications standard * D-1 (Sony), an early digital video recording format * STS-61-A, also known as D-1, the 22nd mission of NASA's Space Shuttle program * D-1, from the Proton (rocket family), Russian rockets * Mercedes D.I, a 1913 German aircraft engine Military World War I fighter aircraft * AEG D.I * Albatros D.I * Halberstadt D.I, experimental version of Halberstadt D.II (and Aviatik D.I variant) * Aviatik (Berg) D.I * Daimler ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Centre For Genetic Engineering And Biotechnology
The International Centre for Genetic Engineering and Biotechnology (ICGEB) was established as a project of the United Nations Industrial Development Organization (UNIDO) in 1983. The Organisation has three Component laboratories with over 45 ongoing research projects in Infectious and Non-communicable diseases, Medical, Industrial and Plant Biology Biotechnology in: Trieste, Italy, New Delhi, India and Cape Town, South Africa. On February 3, 1994, under the direction of Arturo Falaschi Arturo Falaschi (21 January 1933, Rome – 1 June 2010, Montopoli in Val d'Arno) was an Italian geneticist. Biography He graduated in Medicine in 1957 from University of Milan and undertook two post doctoral studies. Firstly, with J. Adler and ... the ICGEB became an autonomous International Organisation and now has over 65 Member States across world regions. Its main pillars of action comprise: Research, Advanced Education through PhD and Postdoctoral Fellowships, International Scientific Me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
