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Spondyloarthropathy
Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such, it is a class or category of diseases rather than a single, specific entity. It differs from spondylopathy, which is a disease of the vertebra itself, but many conditions involve both spondylopathy and spondyloarthropathy. Spondyloarthropathy with inflammation is called axial spondyloarthritis. In the broadest sense, the term spondyloarthropathy includes joint involvement of vertebral column from any type of joint disease, including rheumatoid arthritis and osteoarthritis, but the term is often used for a specific group of disorders with certain common features, which are often specifically termed seronegative spondylarthropathies. They have an increased incidence of HLA-B27, as well as negative rheumatoid factor and ANA. Enthesopathy is also sometimes present in association with seronegative . Non-vertebral signs and symptoms of degenerative or other not directly infected inf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joint Disease
An arthropathy is a disease of a joint. Types Arthritis is a form of arthropathy that involves inflammation of one or more joints, while the term arthropathy may be used regardless of whether there is inflammation or not. Joint diseases can be classified as follows: * Arthritis :*Infection, Infectious arthritis ::*Septic arthritis (infectious) ::* Tuberculosis arthritis ::* Reactive arthritis (indirectly) :*Noninfectious arthritis ::*Seronegative spondyloarthropathy: :::*Psoriatic arthritis :::*Ankylosing spondylitis ::*Rheumatoid arthritis:'' :::* Felty's syndrome ::*Juvenile idiopathic arthritis ::* Adult-onset Still's disease ::*Crystal arthropathy :::*Gout :::*Chondrocalcinosis ::*Osteoarthritis * Hemarthrosis (joint bleeding) * Synovitis is the medical term for inflammation of the synovial membrane. * Joint dislocation With ''arthropathy'' in the name * ''Reactive arthropathy'' (M02-M03) is caused by an infection, but not a direct infection of the synovial space. (See also Rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a type of arthritis characterized by long-term inflammation of the joints of the spine typically where the spine joins the pelvis. Occasionally areas affected may include other joints such as the shoulders or hips, eye and bowel problems may occur as well as back pain. Joint mobility in the affected areas generally worsens over time. Although the cause of ankylosing spondylitis is unknown, it is believed to involve a combination of genetic and environmental factors. More than 85% of those affected in the UK have a specific human leukocyte antigen known as the HLA-B27 antigen. The underlying mechanism is believed to be autoimmune or autoinflammatory. Diagnosis is typically based on the symptoms with support from medical imaging and blood tests. AS is a type of seronegative spondyloarthropathy, meaning that tests show no presence of rheumatoid factor (RF) antibodies. There is no known cure for AS. Treatments may include medication, exercise, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crohn's Disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and fatigue. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer. While the precise causes of Crohn's disease (CD) are unknown, it is believed to be caused by a combination of environmental, immune, and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system defends the gastrointestinal tract, possibly targeting microbial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spondylopathy
Spondylopathies are disorders of the vertebrae. When involving inflammation, it can be called spondylitis. In contrast, a spondyloarthropathy is a condition involving the vertebral joints, but many conditions involve both spondylopathy and spondyloarthropathy. Examples include ankylosing spondylitis and spondylosis. See also * Dorsopathies * Spondyloarthropathy * Spondylolisthesis * Spondylosis * Spondylitis * Spondylolysis References External links Vertebral column disorders {{musculoskeletal-disease-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osteoarthritis
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone which affects 1 in 7 adults in the United States. It is believed to be the fourth leading cause of disability in the world. The most common symptoms are joint pain and stiffness. Usually the symptoms progress slowly over years. Initially they may occur only after exercise but can become constant over time. Other symptoms may include joint swelling, decreased range of motion, and, when the back is affected, weakness or numbness of the arms and legs. The most commonly involved joints are the two near the ends of the fingers and the joint at the base of the thumbs; the knee and hip joints; and the joints of the neck and lower back. Joints on one side of the body are often more affected than those on the other. The symptoms can interfere with work and normal daily activities. Unlike some other types of arthritis, only the joints, not internal organs, are af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B27
Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. Prevalence The prevalence of HLA-B27 varies markedly in the global population. For example, about 8% of Caucasian race, Caucasians, 4% of North African#People, North Africans, 2–9% of Han Chinese, Chinese, and 0.1–0.5% of persons of Yamato people, Japanese descent possess the gene that codes for this antigen. In northern Scandinavia (Lapland (region), Lapland), 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis. Disease associations The relationship between HLA-B27 and many diseases has not yet been fully elu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psoriatic Arthritis
Psoriatic arthritis is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. The classic feature of psoriatic arthritis is swelling of entire fingers and toes with a sausage-like appearance. This often happens in association with changes to the nails such as small depressions in the nail (pitting), thickening of the nails, and detachment of the nail from the nailbed. Skin changes consistent with psoriasis (e.g., red, scaly, and itchy plaques) frequently occur before the onset of psoriatic arthritis but psoriatic arthritis can precede the rash in 15% of affected individuals. It is classified as a type of seronegative spondyloarthropathy. Genetics are thought to be strongly involved in the development of psoriatic arthritis. Obesity and certain forms of psoriasis are thought to increase the risk. Psoriatic arthritis affects up to 30% of people with psoriasis and occurs in both children and adults. Approximately 40–50% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sausage Digits
Dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful. The word dactyl comes from the Greek word "daktylos" meaning "finger". In its medical term, it refers to both the fingers and the toes. Associated conditions Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, and in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts, and in infectious conditions including tuberculosis, syphilis, and leprosy. In reactive arthritis, sausage fingers occur due to synovitis.Robbins, Stanley Leonard; Kumar, Vinay; Abbas, Abdul K.; Cotran, Ramzi S.; Fausto, Nelson (2010). "Robbins and Cotran pathologic basis of disease". In Vinay Kumar, Abul K. Abbas, Nelson Fausto. Robbins Pathology Series (Elsevier). p. 205. . Dactylitis may also be seen with sarcoidosis. In sickle-cell disease it is manifested for the first time between 6-9 month old infants (as their protective fetal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plantar Fasciitis
Plantar fasciitis or plantar heel pain (PHP) is a disorder of the plantar fascia, which is the connective tissue which supports the arch of the foot. It results in pain in the heel and bottom of the foot that is usually most severe with the first steps of the day or following a period of rest. Pain is also frequently brought on by bending the foot and toes up towards the shin. The pain typically comes on gradually, and it affects both feet in about one-third of cases. The cause of plantar fasciitis is not entirely clear. Risk factors include overuse, such as from long periods of standing, an increase in exercise, and obesity. It is also associated with inward rolling of the foot, a tight Achilles tendon, and a sedentary lifestyle. It is unclear if heel spurs have a role in causing plantar fasciitis even though they are commonly present in people who have the condition. Plantar fasciitis is a disorder of the insertion site of the ligament on the bone characterized by micro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enthesopathy
An enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a bone. This site of attachment is known as the enthesis (pl. entheses). If the condition is known to be inflammatory, it can more precisely be called an enthesitis. Forms Enthesopathy can occur at the shoulder, elbow, wrist, carpus, hip, knee, ankle, tarsus, or heel bone, among other regions. Enthesopathies may take the form of spondyloarthropathies (joint diseases of the spine) such as ankylosing spondylitis, plantar fasciitis, and Achilles tendinitis. Further examples include: * Adhesive capsulitis of shoulder * Rotator cuff syndrome of shoulder and allied disorders * Periarthritis of shoulder * Scapulohumeral fibrositis * Synovitis of hand or wrist * Periarthritis of wrist * Gluteal tendinitis * Iliac crest spur * Psoas tendinitis * Trochanteric tendinitis Causes Generalized involvement of the entheses with calcification of tendon and ligament insertions and of joint capsules has bee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Undifferentiated Spondyloarthropathy
Differentiation may refer to: Business * Differentiation (economics), the process of making a product different from other similar products * Product differentiation, in marketing * Differentiated service, a service that varies with the identity of the consumer or the context in which the service is used Science, technology, and mathematics Biology and medicine * Cellular differentiation, in biology * ''Differentiation'' (journal), a peer-reviewed academic journal covering cell differentiation and cell development * Developmental biology, the study of the process by which animals and plants grow and develop * Differentiation therapy, a cancer treatment in which malignant cells are encouraged to differentiate into more mature forms using pharmacological agents Geology * Igneous differentiation, in geology * Planetary differentiation, in planetary science and geology Social sciences * Differentiation (economics), the process of making a product different from other similar produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is the most common, chronic rheumatic disease of childhood, affecting approximately one per 1,000 children. ''Juvenile'', in this context, refers to disease onset before 16 years of age, while ''idiopathic'' refers to a condition with no defined cause, and '' arthritis'' is inflammation within the joint. JIA is an autoimmune, noninfective, inflammatory joint disease, the cause of which remains poorly understood. It is characterised by chronic joint inflammation. JIA is a subset of childhood arthritis, but unlike other, more transient forms of childhood arthritis, JIA persists for at least six weeks, and in some children is a lifelong condition. It differs significantly from forms of arthritis commonly seen in adults (osteoarthritis, rheumatoid arthritis), in terms of cause, disease associations, and prognosis. The prognosis for children with JIA has improved dramatically over recent decades, particularly with the introduction of biological the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
