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Spin–spin Relaxation
In physics, the spin–spin relaxation is the mechanism by which , the transverse component of the magnetization vector, exponentially decays towards its equilibrium value in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–spin relaxation time, known as 2, a time constant characterizing the signal decay. It is named in contrast to 1, the spin–lattice relaxation time. It is the time it takes for the magnetic resonance signal to irreversibly decay to 37% (1/ e) of its initial value after its generation by tipping the longitudinal magnetization towards the magnetic transverse plane. Hence the relation :M_(t) = M_(0) e^ \,. 2 relaxation generally proceeds more rapidly than 1 recovery, and different samples and different biological tissues have different 2. For example, fluids have the longest 2 (on the order of seconds for protons), and water based tissues are in the 40–200  ms range, while fat based tissues are in ...
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Relaxation Transverse Magnetization
Relaxation stands quite generally for a release of tension, a return to equilibrium. In the sciences, the term is used in the following ways: * Relaxation (physics), and more in particular: ** Relaxation (NMR), processes by which nuclear magnetization returns to the equilibrium distribution ** Dielectric relaxation, the delay in the dielectric constant of a material ** Vibrational energy relaxation, the process by which molecules in high energy quantum states return to the Maxwell-Boltzmann distribution ** Chemical relaxation (physics), relaxation methods, related to temperature jump ** Relaxation oscillator, a type of electronic oscillator In mathematics: :* Relaxation (approximation), a technique for transforming hard constraints into easier ones :* Relaxation (iterative method), a technique for the numerical solution of equations :* Mathematical optimization#Relaxation (extension method), Relaxation (extension method), a technique for a natural extension in mathematical optimiza ...
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Exponential Decay
A quantity is subject to exponential decay if it decreases at a rate proportional to its current value. Symbolically, this process can be expressed by the following differential equation, where is the quantity and (lambda) is a positive rate called the exponential decay constant, disintegration constant, rate constant, or transformation constant: :\frac = -\lambda N. The solution to this equation (see derivation below) is: :N(t) = N_0 e^, where is the quantity at time , is the initial quantity, that is, the quantity at time . Measuring rates of decay Mean lifetime If the decaying quantity, ''N''(''t''), is the number of discrete elements in a certain set, it is possible to compute the average length of time that an element remains in the set. This is called the mean lifetime (or simply the lifetime), where the exponential time constant, \tau, relates to the decay rate constant, λ, in the following way: :\tau = \frac. The mean lifetime can be looked at as ...
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Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and ...
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Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books by decree in 1586, it is the second oldest university press after Cambridge University Press. It is a department of the University of Oxford and is governed by a group of 15 academics known as the Delegates of the Press, who are appointed by the vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, opposite Somerville College, in the inner suburb of Jericho. For the last 500 years, OUP has primarily focused on the publication of pedagogical texts an ...
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Spin Echo
In magnetic resonance, a spin echo or Hahn echo is the refocusing of spin magnetisation by a pulse of resonant electromagnetic radiation. Modern nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) make use of this effect. The NMR signal observed following an initial excitation pulse decays with time due to both spin relaxation and any ''inhomogeneous'' effects which cause spins in the sample to precess at different rates. The first of these, relaxation, leads to an irreversible loss of magnetisation. But the inhomogeneous dephasing can be removed by applying a 180° ''inversion'' pulse that inverts the magnetisation vectors. Examples of inhomogeneous effects include a magnetic field gradient and a distribution of chemical shifts. If the inversion pulse is applied after a period ''t'' of dephasing, the inhomogeneous evolution will rephase to form an echo at time 2''t''. In simple cases, the intensity of the echo relative to the initial signal is given by ''e– ...
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Spin–lattice Relaxation
During nuclear magnetic resonance observations, spin–lattice relaxation is the mechanism by which the longitudinal component of the total nuclear magnetic moment vector (parallel to the constant magnetic field) exponentially relaxes from a higher energy, non-equilibrium state to thermodynamic equilibrium with its surroundings (the "lattice"). It is characterized by the spin–lattice relaxation time, a time constant known as ''T1''. There is a different parameter, ''T2'', the spin-spin relaxation time, which concerns the exponential relaxation of the transverse component of the nuclear magnetization vector ( to the external magnetic field). Measuring the variation of ''T1'' and ''T2'' in different materials is the basis for some magnetic resonance imaging techniques. Nuclear physics ''T1'' relaxation or longitudinal relaxation curve ''T1'' characterizes the rate at which the longitudinal ''Mz'' component of the magnetization vector recovers exponentially towards its thermodyna ...
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Steady-state Free Precession Imaging
Steady-state free precession (SSFP) imaging is a magnetic resonance imaging (MRI) sequence which uses steady states of magnetizations. In general, SSFP MRI sequences are based on a (low flip angle) gradient echo MRI sequence with a short repetition time which in its generic form has been described as the FLASH MRI technique. While spoiled gradient-echo sequences refer to a steady state of the longitudinal magnetization only, SSFP gradient-echo sequences include transverse coherences (magnetizations) from overlapping multi-order spin echoes and stimulated echoes. This is usually accomplished by refocusing the phase-encoding gradient in each repetition interval in order to keep the phase integral (or gradient moment) constant. Fully balanced SSFP MRI sequences achieve a phase of zero by refocusing all imaging gradients. Gradient moments are zero or not If, within one TR, either one of the gradient moments of magnetic gradients along three logical directions, including slice selectio ...
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Thermal Equilibrium
Two physical systems are in thermal equilibrium if there is no net flow of thermal energy between them when they are connected by a path permeable to heat. Thermal equilibrium obeys the zeroth law of thermodynamics. A system is said to be in thermal equilibrium with itself if the temperature within the system is spatially uniform and temporally constant. Systems in thermodynamic equilibrium are always in thermal equilibrium, but the converse is not always true. If the connection between the systems allows transfer of energy as 'change in internal energy' but does not allow transfer of matter or transfer of energy as work, the two systems may reach thermal equilibrium without reaching thermodynamic equilibrium. Two varieties of thermal equilibrium Relation of thermal equilibrium between two thermally connected bodies The relation of thermal equilibrium is an instance of equilibrium between two bodies, which means that it refers to transfer through a selectively permeabl ...
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Information Theory
Information theory is the scientific study of the quantification, storage, and communication of information. The field was originally established by the works of Harry Nyquist and Ralph Hartley, in the 1920s, and Claude Shannon in the 1940s. The field is at the intersection of probability theory, statistics, computer science, statistical mechanics, information engineering, and electrical engineering. A key measure in information theory is entropy. Entropy quantifies the amount of uncertainty involved in the value of a random variable or the outcome of a random process. For example, identifying the outcome of a fair coin flip (with two equally likely outcomes) provides less information (lower entropy) than specifying the outcome from a roll of a die (with six equally likely outcomes). Some other important measures in information theory are mutual information, channel capacity, error exponents, and relative entropy. Important sub-fields of information theory include sourc ...
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Spin Echo
In magnetic resonance, a spin echo or Hahn echo is the refocusing of spin magnetisation by a pulse of resonant electromagnetic radiation. Modern nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) make use of this effect. The NMR signal observed following an initial excitation pulse decays with time due to both spin relaxation and any ''inhomogeneous'' effects which cause spins in the sample to precess at different rates. The first of these, relaxation, leads to an irreversible loss of magnetisation. But the inhomogeneous dephasing can be removed by applying a 180° ''inversion'' pulse that inverts the magnetisation vectors. Examples of inhomogeneous effects include a magnetic field gradient and a distribution of chemical shifts. If the inversion pulse is applied after a period ''t'' of dephasing, the inhomogeneous evolution will rephase to form an echo at time 2''t''. In simple cases, the intensity of the echo relative to the initial signal is given by ''e– ...
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Chemical Shift
In nuclear magnetic resonance (NMR) spectroscopy, the chemical shift is the resonant frequency of an atomic nucleus relative to a standard in a magnetic field. Often the position and number of chemical shifts are diagnostic of the structure of a molecule. Chemical shifts are also used to describe signals in other forms of spectroscopy such as photoemission spectroscopy. Some atomic nuclei possess a magnetic moment (nuclear spin), which gives rise to different energy levels and resonance frequencies in a magnetic field. The total magnetic field experienced by a nucleus includes local magnetic fields induced by currents of electrons in the molecular orbitals (note that electrons have a magnetic moment themselves). The electron distribution of the same type of nucleus (e.g. ) usually varies according to the local geometry (binding partners, bond lengths, angles between bonds, and so on), and with it the local magnetic field at each nucleus. This is reflected in the spin energy ...
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