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Spider Lamb Syndrome
Spider lamb syndrome, also known as spider syndrome and more formally as ovine hereditary chondrodysplasia, is a homozygous recessive disorder affecting the growth of cartilage and bone in sheep. The name derives from the limbs of afflicted animals being thin, elongated, and "spider-like". It is a semilethal trait,Spider Lamb Syndrome: Introduction at ; retrieved July 19, 2012 which is thought to have been first observed in the 1970s, and is most common in sheep of the Suffolk and |
Homozygous
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") () is the degree to which both copies of a chromosome or gene have the same genetic sequence. In other words, it is the degree of similarity of the alleles in an organism. Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex-determination system. If both alleles of a diploid organism are the same, the organism is homozygous at that locus. If they are different, the organism is heterozygous at that locus. If one allele is missing, it is hemizygous, and, if both alleles are missing, it is nullizygous. The DNA sequence of a gene often varies from one individual to another. These gene variants are called alleles. While some gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recessive
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and the second recessive. This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes ( autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one copy of the Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, there are other forms of dominance such as incomplete d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cartilage
Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck and the bronchial tubes, and the intervertebral discs. In other taxa, such as chondrichthyans, but also in cyclostomes, it may constitute a much greater proportion of the skeleton. It is not as hard and rigid as bone, but it is much stiffer and much less flexible than muscle. The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body. Examples include the rings of the trachea, such as the cricoid cartilage and carina. Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bone
A bone is a Stiffness, rigid Organ (biology), organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red blood cell, red and white blood cells, store minerals, provide structure and support for the body, and enable animal locomotion, mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple Function (biology), functions. Bone tissue (osseous tissue), which is also called bone in the mass noun, uncountable sense of that word, is hard tissue, a type of specialized connective tissue. It has a honeycomb-like matrix (biology), matrix internally, which helps to give the bone rigidity. Bone tissue is made up of different types of bone cells. Osteoblasts and osteocytes are involved in the formation and mineralization (biology), mineralization of bone; osteoclasts are involved in the bone resorption, resor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sheep
Sheep or domestic sheep (''Ovis aries'') are domesticated, ruminant mammals typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus ''Ovis'', in everyday usage it almost always refers to domesticated sheep. Like all ruminants, sheep are members of the order Artiodactyla, the even-toed ungulates. Numbering a little over one billion, domestic sheep are also the most numerous species of sheep. An adult female is referred to as a ''ewe'' (), an intact male as a ''ram'', occasionally a ''tup'', a castrated male as a ''wether'', and a young sheep as a ''lamb''. Sheep are most likely descended from the wild mouflon of Europe and Asia, with Iran being a geographic envelope of the domestication center. One of the earliest animals to be domesticated for agricultural purposes, sheep are raised for fleeces, meat (lamb, hogget or mutton) and milk. A sheep's wool is the most widely used animal fiber, and is usually harvested by shearing. In Commonw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UC Davis School Of Veterinary Medicine
The University of California, Davis, School of Veterinary Medicine is the largest veterinary school in the United States. Established in 1948, the school is the primary health resource for California's various animal populations. In 2020, the school was again ranked No. 1 in the United States by '' U.S. News & World Report'' and in 2021, ranked No. 2 in the world bQS World University Rankings The school is located in the southwest corner of the main campus of the University of California, Davis. The current Dean of Veterinary Medicine is Dr. Mark Stetter. The School focuses on students of the professional Doctor of Veterinary Medicine program, the Master of Preventive Veterinary Medicine program, graduate clinical residency programs, and graduate academic MS and PhD programs. The School of Veterinary Medicine provides educational, research, clinical service, and public service programs to advance the health and care of animals, the health of the environment, and public health. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
North Dakota State University
North Dakota State University (NDSU, formally North Dakota State University of Agriculture and Applied Sciences) is a public land-grant research university in Fargo, North Dakota. It was founded as North Dakota Agricultural College in 1890 as the state's land-grant university. As of 2021, NDSU offers 94 undergraduate majors, 146 undergraduate degree programs, 5 undergraduate certificate programs, 84 undergraduate minors, 87 master's degree programs, 51 doctoral degree programs of study, and 210 graduate certificate programs. NDSU is part of the North Dakota University System. The university also operates North Dakota's agricultural research extension centers distributed across the state on 18,488 acres (75 km2). In 2015, NDSU's economic impact on the state and region was estimated to be $1.3 billion a year according to the NDUS Systemwide Economic Study by the School of Economics at North Dakota State University. In 2016, it was also the fifth-largest employer in the state ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suffolk (sheep)
The Suffolk is a British breed of domestic sheep. It originated in the late eighteenth century in the area of Bury St. Edmunds in Suffolk, as a result of cross-breeding when Norfolk Horn ewes were put to improved Southdown rams. It is a polled, black-faced breed, and is raised primarily for its meat. It has been exported to many countries, and is among the most numerous breeds of sheep worldwide. History The Suffolk originated in the area surrounding Bury St. Edmunds in Suffolk in the late eighteenth century, as a result of cross-breeding when Norfolk Horn ewes were put to improved Southdown rams. They were at first known as Blackfaces or Southdown-Norfolks; the first use of the name "Suffolk" for these sheep dates to 1797. In 1810 it was recognised as distinct breed, but was not known by the present name until 1859. A breed society, the English Suffolk Society, was formed in 1886; a flock-book published in the following year recorded some ewes. By the end of the nineteen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hampshire Sheep
The Hampshire Down or Hampshire is a British breed of sheep. It originated in about 1829 from cross-breeding of Southdowns with the Old Hampshire breed, the Wiltshire Horn and the Berkshire Nott, all horned, white-faced sheep — these were native to the open, untilled, hilly stretch of land known as the Hampshire Downs. It is much used as a terminal sire. History John Twynam, a Hampshire farmer, crossed his then-Hampshire flock with Cotswold rams around 1829. The resultant half-bred rams were compact and blocky animals, and from around 1835 were sold into six or more of what were to become the first recognised pedigree Hampshire Down flocks in the United Kingdom. An important flock was kept at Downton Agricultural College in the late 19th-century. The Southdowns had long dark brown or black legs, matured early, produced the best of mutton and a fine quality of medium wool. The original Hampshire was larger, coarser, but hardier, slower to mature, with inferior flesh, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merck Veterinary Manual
The ''Merck Veterinary Manual'' is a reference manual of animal health care. It was first published by Merck & Co., Inc. in 1955. It contains concise, thorough information on the diagnosis and treatment of disease in a wide variety of species. The ''Manual'' is available as a book, published on a non-profit basis. Additionally, the full text can be accessed for free via the website, or downloaded in its entirety via an app. In January 2020, the website was redesigned with a more helpful search function without advertising. Interactive features on the website include quizzes, case studies, and clinical calculators. In addition, there are animal health news summaries and commentaries. History The ''Merck Veterinary Manual'' was first published in 1955. It was based on the ''Merck Manual of Diagnosis and Therapy'', which was first published in 1899 as a reference for physicians. The first edition of the ''Veterinary Manual'' included contributions from over 200 authors, with 389 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Liège
The University of Liège (french: Université de Liège), or ULiège, is a major public university of the French Community of Belgium based in Liège, Wallonia, Belgium. Its official language is French. As of 2020, ULiège is ranked in the 301–350 category worldwide according to ''Times Higher Education'', 451st by ''QS World University Rankings'', and between the 201st and 300th place by the '' Academic Ranking of World Universities''. More than 2,000 people, including academics, scientists and technicians, are involved in research of a wide variety of subjects from basic research to applied research. History The university was founded in 1817 by William I of the Netherlands, then King of the United Kingdom of the Netherlands, and by his Minister of Education, Anton Reinhard Falck. The foundation of the university was the result of a long intellectual tradition which dates back to the origins of the Prince-Bishopric of Liège. Beginning in the eleventh century, the influenc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblast Growth Factor Receptor 3
Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the ''FGFR3'' gene. FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location q16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys. The FGFR3 gene produces various forms of the FGFR3 protein; the location varies depending on the isoform of the FGFR3 protein. Since the different forms are found within different tissues the protein is responsible for multiple growth factor interactions. Gain of function mutations in FGFR3 inhibits chondrocyte proliferation and underlies achondroplasia and hypochondroplasia. Function The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
