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Smac (film)
SMAC may refer to: Biology and medicine * Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway * Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests * Supramolecular activation cluster, the structure comprising the immunological synapse Other uses *Sabang Merauke Raya Air Charter, an Indonesian airline *'' Sid Meier's Alpha Centauri'', a computer game *Southern Maryland Athletic Conference * Southwestern Michigan Athletic Conference * Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America *Supreme Macedonian-Adrianople Committee Supreme Macedonian-Adrianople Committee (SMAC), ( bg, Върховен македоно - одрински комитет, (ВМОК)), also known as Supreme Macedonian Committee was a Bulgarian paramilitary and political organization, active i ... * Social Mobile Analytics Cloud, also called as the '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second Mitochondria-derived Activator Of Caspases
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the ''DIABLO'' (direct IAP binding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments. Structure Protein This gene encodes a 130 Å-long, arch-shaped homodimer protein. The full-length protein product spans 239 residues, 55 of which comprise the mitochondrial-targeting sequence (MTS) at its N-terminal. However, once the full-length protein is imported into the mitochondria, this sequence is excised to produce the 184-residue mature protein. This cleavage also exposes four residues at the N-terminal, Ala-Val-Pro-Ile (AVPI), which is the core of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequential Multiple Analysis - Computer
The comprehensive metabolic panel, or chemical screen (CMP; CPT code 80053), is a panel of 14 blood tests that serves as an initial broad medical screening tool. The CMP provides a rough check of kidney function, liver function, diabetic and parathyroid status, and electrolyte and fluid balance, but this type of screening has its limitations. Abnormal values from a CMP are often the result of false positives and thus the CMP may need to be repeated (or a more specific test performed), requiring a second blood drawing procedure and possibly additional expense for the patient, even though no disease is present. This test is also known as SMA12+2 test. The CMP is an expanded version of the basic metabolic panel (BMP), which does not include liver tests. A CMP (or BMP) can be ordered as part of a routine physical examination, or may be used to monitor a patient with a chronic disease, such as diabetes mellitus or hypertension. Previous names for the panel of tests have been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Supramolecular Activation Cluster
In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as a T/B cell or Natural Killer cell. The interface was originally named after the neuronal synapse, with which it shares the main structural pattern. An immunological synapse consists of molecules involved in T cell activation, which compose typical patterns—activation clusters. Immunological synapses are the subject of much ongoing research. Structure and function The immune synapse is also known as the supramolecular activation cluster or SMAC. This structure is composed of concentric rings each containing segregated clusters of proteins—often referred to as the bull’s-eye model of the immunological synapse: * c-SMAC (central-SMAC) composed of the θ isoform of protein kinase C, CD2, CD4, CD8, CD28, Lck, and Fyn. * p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated antigen-1 ( LFA-1) and the cyt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |