|
Skraup Synthesis
The Skraup synthesis is a chemical reaction used to synthesize quinolines. It is named after the Czech chemist Zdenko Hans Skraup (1850-1910). In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol, and an oxidizing agent such as nitrobenzene to yield quinoline. In this example, nitrobenzene serves as both the solvent and the oxidizing agent. The reaction, which otherwise has a reputation for being violent, is typically conducted in the presence of ferrous sulfate. Arsenic acid Arsenic acid or trihydrogen arsenate is the chemical compound with the formula . More descriptively written as , this colorless acid is the arsenic analogue of phosphoric acid. Arsenate and phosphate salts behave very similarly. Arsenic acid as ... may be used instead of nitrobenzene and the former is better since the reaction is less violent. See also * Bischler-Napieralski reaction * Doebner-Miller reaction References {{DEFAULTSORT:Skraup Reaction Condensatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zdenko Hans Skraup
Zdenko Hans Skraup (March 3, 1850 – September 10, 1910) was a Czech-Austrian chemist who discovered the Skraup reaction, the first quinoline synthesis. Life Skraup was born in Prague, where he attended the Oberrealschule from 1860 till 1866 and subsequently studied (1866–1871) at the Technical University of Prague. After being assistant of Heinrich Ludwig Buff for less than a year he worked at a china factory but changed to the mint in Vienna in 1873. He became assistant of Rochleder in 1873, although a promotion in his old job was granted. Rochleder died the following year, but Skraup stayed with his successors Franz Schneider and Adolf Lieben. He received his Ph.D. from the University of Gießen March 17, 1875. He finished his habilitation at the University of Vienna in 1879, but because his degree was from a German university he had to wait until 1881 till he became professor at the Vienna Trade Academie. In 1886, he changed to the University of Graz The Unive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |