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Simon Flexner
Simon Flexner, M.D. (March 25, 1863 in Louisville, Kentucky – May 2, 1946) was a physician, scientist, administrator, and professor of experimental pathology at the University of Pennsylvania (1899–1903). He served as the first director of the Rockefeller Institute for Medical Research (1901–1935) (later developed as Rockefeller University) and a trustee of the Rockefeller Foundation. He was also a friend and adviser to John D. Rockefeller Jr. Among Flexner's most important achievements are studies into poliomyelitis and the development of serum treatment for meningitis. Among his lab assistants were Hideyo Noguchi and Cornelius Rhoads, later directors of Memorial Hospital and the Sloan-Kettering Institute, respectively. The bacteria species ''Shigella flexneri'' was named in recognition of Flexner. In addition, Flexner was the first to describe Flexner-Wintersteiner rosettes, a characteristic finding in retinoblastoma, a type of cancer. Early life and career Simon was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Retinoblastoma
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye. It is the most common primary malignant intraocular cancer in children, and it is almost exclusively found in young children. Though most children survive this cancer, they may lose their vision in the affected eye(s) or need to have the eye removed. Almost half of children with retinoblastoma have a hereditary genetic defect associated with retinoblastoma. In other cases, it is caused by a congenital mutation in the chromosome 13 gene 13q14 (retinoblastoma protein). Signs and symptoms Retinoblastoma is universally known as the most intrusive intraocular cancer among children. The chance of survival and preservation of the eye depends fully on the severity. Retinoblastoma is extremely rare as there are only about 200 to 300 cases every year in the United States. Looking at retinoblastoma globally, only 1 in about 15,000 children have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flexner-Wintersteiner Rosette
In histopathology, a palisade is a single layer of relatively long cells, arranged loosely perpendicular to a surface and parallel to each other. A rosette is a palisade in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. A pseudorosette is a perivascular radial arrangement of neoplastic cells around a small blood vessel. Rosette A ''rosette'' is a cell formation in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core: the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub. Pathogenesis Rosettes may be considered primary or secondary manifestations of tumor architecture. Primary rosettes form as a characteristic growth pattern of a given tumor type wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shigella Flexneri
''Shigella flexneri'' is a species of Gram-negative bacteria in the genus ''Shigella'' that can cause diarrhea in humans. Several different serogroups of ''Shigella'' are described; ''S. flexneri'' belongs to group ''B''. ''S. flexneri'' infections can usually be treated with antibiotics, although some strains have become resistant. Less severe cases are not usually treated because they become more resistant in the future. Shigella are closely related to ''Escherichia coli'', but can be differentiated from ''E.coli'' based on pathogenicity, physiology (failure to ferment lactose or decarboxylate lysine) and serology. Discovery The species was named after the American physician Simon Flexner; the genus Shigella is named after Japanese physician Kiyoshi Shiga, who researched the cause of dysentery. Shiga entered the Tokyo Imperial University School of Medicine in 1892, during which he attended a lecture by Dr. Shibasaburo Kitasato. Shiga was impressed by Dr. Kitasato's intellect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sloan-Kettering Institute
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute–designated Comprehensive Cancer Centers. Its main campus is located at 1275 York Avenue, between 67th and 68th streets, in Manhattan. According to U.S. News & World Report 2021-2022 Best Hospitals, Memorial Sloan Kettering Cancer Center (MSK) has been ranked as the number two hospital for cancer care in the nation. History New York Cancer Hospital (1884–1934) Memorial Hospital was founded on the Upper West Side of Manhattan in 1884 as the New York Cancer Hospital by a group that included John Jacob Astor III and his wife Charlotte. The hospital appointed as an attending surgeon William B. Coley, who pioneered an early form of immunotherapy to eradicate tumors. Rose Hawthorne, daughter of author Nathaniel Hawthorne, trained there in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Memorial Hospital (New York City, New York)
Memorial Hospital may refer to: __NOTOC__ United Kingdom * Memorial Hospital, Woolwich * Scunthorpe General Hospital, Lincolnshire, previously known as the Scunthorpe and District War Memorial Hospital United States * Memorial Hospital (Chattanooga), in Chattanooga, Tennessee * Memorial Hospital (Cumberland), in Cumberland, Maryland, opened 1888, closed 2009 * Guthrie Towanda Memorial Hospital, formerly known as simply Memorial Hospital * Memorial Hospital (New York City, New York), a former hospital in New York City * Memorial Hospital of Rhode Island * Memorial Hospital and Health Care Center in Jasper, Indiana * Memorial Hospital of South Bend in South Bend, Indiana * Ochsner Baptist Medical Center (New Orleans), formerly known as Memorial Medical Center Other countries * Memorial Hospital, North Adelaide A memorial is an object or place which serves as a focus for the memory or the commemoration of something, usually an influential, deceased person or a historical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornelius Rhoads
Cornelius Packard "Dusty" Rhoads (June 9, 1898 – August 13, 1959) was an American pathologist, oncologist, and hospital administrator who was involved in a racist scandal and subsequent whitewashing in the 1930s. Beginning in 1940, he served as director of Memorial Hospital for Cancer Research in New York, from 1945 was the first director of Sloan-Kettering Institute, and the first director of the combined Memorial Sloan–Kettering Cancer Center. For his contributions to cancer research, Rhoads was featured on the cover of the June 27, 1949 issue of ''Time'' magazine under the title "Cancer Fighter". During his early years with the Rockefeller Institute in the 1930s, Rhoads specialized in anemia and leukemia, working for six months in Puerto Rico in 1932 as part of the Rockefeller Foundation International Health Board contingent. During World War II, he worked for the United States Army helping to develop chemical weapons and set up research centers. Research on mustard ga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hideyo Noguchi
, also known as , was a prominent Japanese bacteriologist who in 1911 discovered the agent of syphilis as the cause of progressive paralytic disease. Early life Noguchi Hideyo whose childhood name was Seisaku Noguchi was born to a family of farmers for generations in Inawashiro, Fukushima prefecture in 1876. When he was one and a half years old, he fell into a fireplace and suffered a burn injury on his left hand. There was no doctor in the small village, but one of the men examined the boy. "The fingers of the left hand are mostly gone," he said, "and the left arm, the left foot, and the right hand are burned; I don't know how badly." In 1883, Noguchi entered Mitsuwa elementary school. Thanks to generous contributions from his teacher Kobayashi and his friends, he was able to receive surgery on his badly burned hand. He recovered about 70% mobility and functionality in his left hand through the operation. Noguchi decided to become a doctor to help those in need. He apprenticed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meningitis
Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or altered consciousness, nausea, vomiting, and an inability to tolerate light or loud noises. Young children often exhibit only nonspecific symptoms, such as irritability, drowsiness, or poor feeding. A non-blanching rash (a rash that does not fade when a glass is rolled over it) may also be present. The inflammation may be caused by infection with viruses, bacteria or other microorganisms. Non-infectious causes include malignancy (cancer), subarachnoid haemorrhage, chronic inflammatory disease (sarcoidosis) and certain drugs. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. A lumbar puncture, in which a needle is inserte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poliomyelitis
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia. These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases.. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection. Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal-oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral-oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son "Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York. The foundation has had an international reach since the 1930s and major influence on global non-governmental organizations. The World Health Organiza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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