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Shu Hongbing
Shu Hongbing (; born January 1967) is a Chinese cytologist and immunologist. He became a member of the Chinese Academy of Sciences in 2011 and TWAS in 2012. Shu is mainly known for his work on cell signal transduction related to immunity. Life Shu Hongbing was born to a poor rural family in Rongchang County, Chongqing. His mother died when he was 9 years old. When Shu entered senior high school, he failed the chemistry exam, and did not know any English. He had to go to school barefoot because he could not afford to buy shoes. However, by the time he finished high school with a national stipend in 1983, he was accepted by Lanzhou University with the highest National Matriculation Examination score in his class. After graduating in 1987, Shu entered the Chinese Academy of Medical Sciences Basic Medical Institute Cell Laboratory, where he obtained his master's degree three years later. In 1990, Shu went to the United States and worked as a research assistant at the University of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rongchang District
Rongchang District () is a district of Chongqing Municipality, China, bordering Sichuan province to the west. The district, with a population of 800,000, is located in the west of Chongqing. Administration Climate Notable people * Shu Hongbing Shu Hongbing (; born January 1967) is a Chinese cytologist and immunologist. He became a member of the Chinese Academy of Sciences in 2011 and TWAS in 2012. Shu is mainly known for his work on cell signal transduction related to immunity. Life ... (; born 1967) Chinese cytologist and immunologist References External linksRongchang Government website Districts of Chongqing {{Chongqing-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TWAS
The World Academy of Sciences (TWAS) is a merit-based science academy established for developing countries, uniting 1,000 scientists in some 70 countries. Its principal aim is to promote scientific capacity and excellence for sustainable development in developing countries. It was formerly known as the ''Third World Academy of Sciences''. Its headquarters is located on the premises of the Abdus Salam International Centre for Theoretical Physics (ICTP) in Trieste, Italy. History TWAS was founded in 1983 under the leadership of the Nobel Laureate Abdus Salam of Pakistan by a group of distinguished scientists who were determined to do something about the dismal state of scientific research in developing countries. * Although developing countries account for 80% of the world's population, only 28% of the world's scientists hail from these countries. This fact reflects the lack of innovative potential necessary to solve real-life problems affecting poor nations. * A chronic lack of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Two-hybrid Screening
Two-hybrid screening (originally known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively. The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the DNA-binding domain (DBD or often also abbreviated as BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay. History Pioneered by Stanley Fields and Ok-Kyu Song in 1989, the technique was originally designed to detect protein–protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caspase-8
Caspase-8 is a caspase protein, encoded by the ''CASP8'' gene. It most likely acts upon caspase-3. ''CASP8'' orthologs have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds. Function The ''CASP8'' gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casper (protein)
Casper may refer to: People * Casper (given name) * Casper (surname) * Casper (Maya ruler) (422–487?), ruler of the Mayan city of Palenque * Tok Casper, first known king of Maya city-state Quiriguá in Guatemala, ruling beginning in 426 * David Gray (snooker player) (born 1979), nicknamed Casper * Casper (rapper) (born 1982), German musician * DJ Casper (born 1971), American musician Places in the United States * Casper, Wyoming, a city * Casper Mountain, overlooking Casper, Wyoming Entertainment * Casper Gutman, the primary antagonist of '' The Maltese Falcon.'' * Casper the Friendly Ghost, a Paramount cartoon character owned by Harvey Comics ** Casper the Friendly Ghost in film, a series of films based on the Harvey Comics character *** ''Casper'' (film), a 1995 live-action film featuring Casper the Friendly Ghost *** '' Casper: A Spirited Beginning'', a direct-to-video prequel of the 1995 film *** ''Casper Meets Wendy'', a direct-to-video sequel to ''Casper: A Spirited ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FADD
FAS-associated death domain protein, also called MORT1, is encoded by the ''FADD'' gene on the 11q13.3 region of chromosome 11 in humans. FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development. Structure FADD is a 23 kDa protein, made up of 208 amino acids. It contains two main domains: a C terminal death domain (DD) and an N terminal death effector domain (DED). Each domain, although sharing very little sequence similarity, are structurally similar to one another, with each consisting of 6 α helices. The DD of FADD binds to receptors such as the Fas receptor at the plasma membrane via their DD. The interaction between the death domains are elec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRAIL
A trail, also known as a path or track, is an unpaved lane or small road usually passing through a natural area. In the United Kingdom and the Republic of Ireland, a path or footpath is the preferred term for a pedestrian or hiking trail. The term is also applied in North America to routes along rivers, and sometimes to highways. In the US, the term was historically used for a route into or through wild territory used by explorers and migrants (e.g. the Oregon Trail). In the United States, "trace" is a synonym for trail, as in Natchez Trace. Some trails are dedicated only for walking, cycling, horse riding, snowshoeing or cross-country skiing, but not more than one use; others, as in the case of a bridleway in the UK, are multi-use and can be used by walkers, cyclists and equestrians alike. There are also unpaved trails used by dirt bikes and other off-road vehicles, and in some places, like the Alps, trails are used for moving cattle and other livestock. Usage In Austra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Jewish Medical And Research Center
National Jewish Health is a Denver, Colorado academic hospital/clinic doing research and treatment in respiratory, cardiac, immune and related disorders. It is an internationally respected medical center that draws people from many countries to receive care. Founded in 1899 to treat tuberculosis,National Jewish Hospital Records "University of Denver" it is but had funding from until the 1950s. The hospital, originally named as the National Jewish Hospital for Consumptives has been renamed many times ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Michigan
, mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As of October 25, 2021. , president = Santa Ono , provost = Laurie McCauley , established = , type = Public research university , academic_affiliations = , students = 48,090 (2021) , undergrad = 31,329 (2021) , postgrad = 16,578 (2021) , administrative_staff = 18,986 (2014) , faculty = 6,771 (2014) , city = Ann Arbor , state = Michigan , country = United States , coor = , campus = Midsize City, Total: , including arboretum , colors = Maize & Blue , nickname = Wolverines , sporti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Higher Education Entrance Examination
The National College Entrance Examination (NCEE), commonly known as the gaokao (), is a standardized college entrance exam held annually in mainland China. It is required for entrance into almost all higher education institutions at the undergraduate level, including for short cycle (2 year) and long cycle (4 year) degree programs. It is usually taken by students in their third and last year of senior high school, but the age requirement was abolished in 2001. The exams last about nine hours over a period of two or three days, depending on the province in which it is held. The Standard Chinese language and mathematics are included in all tests. Candidates can choose one subject from English, French, Japanese, Russian, German or Spanish for the foreign language portion of the test, with most students selecting English. In most regions, students must also choose between either the liberal-arts-oriented concentration () or the natural-science-oriented concentration (). Students w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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