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Shosaku Numa
was a Japanese neuroscientist known for his pioneering research on neurotransmitters and ion channels, and for his contributions to the understanding of molecular mechanisms of neural signalling. Biography Numa was born in Wakayama, Japan and completed his M.D. in 1952 at Kyoto University. He studied at Harvard Medical School with John Lawrence Oncley and worked at the Max Planck Society with Feodor Felix Konrad Lynen, before he became Professor of Medical Chemistry at the Faculty of Medicine, Kyoto University in 1968. He died of colon cancer on February 15, 1992, at the age of 63. Contributions Numa and co-workers cloned and sequenced the cDNA and delineated the primary structures of different families of receptors and channels including a neurotransmitter-gated channel (nicotinic acetylcholine receptor), voltage-gated channels (sodium channel and calcium channel), an intracellular membrane channel ( calcium-release channel), and a G-protein-coupled receptor (muscarinic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wakayama, Japan
is a prefecture of Japan located in the Kansai region of Honshu. Wakayama Prefecture has a population of 944,320 () and has a geographic area of . Wakayama Prefecture borders Osaka Prefecture to the north, and Mie Prefecture and Nara Prefecture to the northeast. Wakayama is the capital and largest city of Wakayama Prefecture, with other major cities including Tanabe, Hashimoto, and Kinokawa. Wakayama Prefecture is located on the western coast of the Kii Peninsula on the Kii Channel, connecting the Pacific Ocean and Seto Inland Sea, across from Tokushima Prefecture on the island of Shikoku. History Present-day Wakayama is mostly the western part of the province of Kii. 1953 flood disaster On July 17–18, 1953, a torrential heavy rain occurred, followed by collapse of levees, river flooding and landslides in a wide area. Many bridges and houses were destroyed. According to an officially confirmed report by the Government of Japan, 1,015 people died, with 5,709 injured a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Lawrence Oncley
John Lawrence Oncley (February 14, 1910 – July 14, 2004) was an American biochemist, and professor emeritus at University of Michigan. Life He graduated from Southwestern College, and University of Wisconsin with a Ph.D. in 1932. He taught at University of Michigan from 1962 to 1980. Martha L. Ludwig was the ''J. Lawrence Oncley Distinguished University Professor of Biological Chemistry'' until she died in 2006. Awards *1942 ACS Award in Pure Chemistry The American Chemical Society Award in Pure Chemistry is awarded annually by the American Chemical Society (ACS) "to recognize and encourage fundamental research in pure chemistry carried out in North America by young men and women." "Young" me ... *He was a member of the National Academy of Sciences. References 1910 births 2004 deaths American biochemists Members of the United States National Academy of Sciences University of Michigan faculty Presidents of the Biophysical Society {{US-biochemist-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1992 Deaths
Year 199 ( CXCIX) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was sometimes known as year 952 ''Ab urbe condita''. The denomination 199 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Mesopotamia is partitioned into two Roman provinces divided by the Euphrates, Mesopotamia and Osroene. * Emperor Septimius Severus lays siege to the city-state Hatra in Central-Mesopotamia, but fails to capture the city despite breaching the walls. * Two new legions, I Parthica and III Parthica, are formed as a permanent garrison. China * Battle of Yijing: Chinese warlord Yuan Shao defeats Gongsun Zan. Korea * Geodeung succeeds Suro of Geumgwan Gaya, as king of the Korean kingdom of Gaya (traditional date). By topic Religion * Pope Zephyrinus succeeds Pope Victor I, as th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1929 Births
Nineteen or 19 may refer to: * 19 (number), the natural number following 18 and preceding 20 * one of the years 19 BC, AD 19, 1919, 2019 Films * ''19'' (film), a 2001 Japanese film * ''Nineteen'' (film), a 1987 science fiction film Music * 19 (band), a Japanese pop music duo Albums * ''19'' (Adele album), 2008 * ''19'', a 2003 album by Alsou * ''19'', a 2006 album by Evan Yo * ''19'', a 2018 album by MHD * ''19'', one half of the double album ''63/19'' by Kool A.D. * ''Number Nineteen'', a 1971 album by American jazz pianist Mal Waldron * ''XIX'' (EP), a 2019 EP by 1the9 Songs * "19" (song), a 1985 song by British musician Paul Hardcastle. * "Nineteen", a song by Bad4Good from the 1992 album '' Refugee'' * "Nineteen", a song by Karma to Burn from the 2001 album ''Almost Heathen''. * "Nineteen" (song), a 2007 song by American singer Billy Ray Cyrus. * "Nineteen", a song by Tegan and Sara from the 2007 album '' The Con''. * "XIX" (song), a 2014 song by Slip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Person Of Cultural Merit
is an official Japanese recognition and honor which is awarded annually to select people who have made outstanding cultural contributions. This distinction is intended to play a role as a part of a system of support measures for the promotion of creative activities in Japan. By 1999, 576 people had been selected as Persons of Cultural Merit. Ministry of Education, Culture, Sports, Science and Technology (Japan) ''Culture 2000''./ref> System of recognition The Order of Culture and Persons of Cultural Merit function in tandem to honor those who have contributed to the advancement and development of Japanese culture in a variety of fields, including academia, arts, science and sports. ''Yomiuri Shimbun.'' October 29, 2008. Persons of Cultural Merit [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Academy Of Natural Scientists Leopoldina
The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on January 1, 1652, based on academic models in Italy, it was originally named the ''Academia Naturae Curiosorum'' until 1687 when Emperor Leopold I raised it to an academy and named it after himself. It was since known under the German name ''Deutsche Akademie der Naturforscher Leopoldina'' until 2007, when it was declared to be Germany's National Academy of Sciences. History ' The Leopoldina was founded in the imperial city of Schweinfurt on 1 January 1652 under the Latin name sometimes translated into English as "Academy of the Curious as to Nature." It was founded by four local physicians- Johann Laurentius Bausch, the first president of the society, Johann Michael Fehr, Georg Balthasar Metzger, and Georg Balthasar Wohlfarth; and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscarinic Acetylcholine Receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpine and scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Function Acetylcholine (ACh) is a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Muscarinic receptors are used in the following roles: Recovery receptors ACh is always used as the neur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcium Channel
A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, although there are also ligand-gated calcium channels. Comparison tables The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated. Voltage-gated Ligand-gated *the ''receptor-operated calcium channels'' (in vasoconstriction) **P2X receptors Page 479 Pharmacology L-type calcium channel blockers are used to treat hypertension. In most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel; also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states. Even though the resting and inactive states would not allow the ions to flow through the channels the difference exists with respect to their structural conformation. Selectivity Sodium channels are highly selective for the transport of ions across cell membr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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