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Shivering
Shivering (also called shuddering) is a bodily function in response to cold and extreme fear in warm-blooded animals. When the core body temperature drops, the shivering reflex is triggered to maintain homeostasis. Skeletal muscles begin to shake in small movements, creating warmth by expending energy. Shivering can also be a response to fever, as a person may feel cold. During fever, the hypothalamic set point for temperature is raised. The increased set point causes the body temperature to rise ( pyrexia), but also makes a person feel cold until the new set point is reached. Biological basis Located in the posterior hypothalamus near the wall of the third ventricle is an area called the primary motor center for shivering. This area is normally inhibited by signals from the heat center in the anterior hypothalamic-preoptic area but is excited by cold signals from the skin and spinal cord and becomes activated when the body temperature falls even a fraction of a degree below ...
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Thermogenesis
Thermogenesis is the process of heat production in organisms. It occurs in all warm-blooded animals, and also in a few species of thermogenic plants such as the Eastern skunk cabbage, the Voodoo lily ('' Sauromatum venosum''), and the giant water lilies of the genus '' Victoria''. The lodgepole pine dwarf mistletoe, '' Arceuthobium americanum'', disperses its seeds explosively through thermogenesis. Types Depending on whether or not they are initiated through locomotion and intentional movement of the muscles, thermogenic processes can be classified as one of the following: * Obligatory Thermogenesis: Heat produced from energy expended for vital metabolic processes necessary to sustain an organism. * Exercise activity thermogenesis (EAT) * Non-exercise activity thermogenesis (NEAT): Energy expended for any spontaneous physical activity that is not a structured exercise routine or sports-like exercise. This can include but is not limited to walking, leisure activities, fid ...
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Tremor
A tremor is an involuntary, somewhat rhythmic muscle contraction and relaxation involving neural oscillations, oscillations or twitching movements of one or more body parts. It is the most common of all involuntary movements and can affect the hands, arms, eyes, face, head, vocal folds, trunk, and legs. Most tremors occur in the hands. In some people, a tremor is a symptom of another neurological disorder. Types Tremor is most commonly classified by clinical features and cause or origin. Some of the better-known forms of tremor, with their symptoms, include the following: * Cerebellar tremor (also known as intention tremor) is a slow, broad tremor of the extremities that occurs at the end of a purposeful movement, such as trying to press a button or touching a finger to the tip of one's nose. In classic cerebellar tremor, a lesion on one side of the brain produces a tremor in that same side of the body that worsens with directed movement. Cerebellar damage can also produce a "win ...
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Myoclonus
Myoclonus is a brief, involuntary, irregular (lacking rhythm) twitching of a muscle, a joint, or a group of muscles, different from clonus, which is rhythmic or regular. Myoclonus ( myo- "muscle", clonus "spasm") describes a medical sign and, generally, is not a diagnosis of a disease. It belongs to the hyperkinetic movement disorders, among tremor and chorea for example. These myoclonic twitches, jerks, or seizures are usually caused by sudden muscle contractions (''positive myoclonus'') or brief lapses of contraction (''negative myoclonus''). The most common circumstance under which they occur is while falling asleep ( hypnic jerk). Myoclonic jerks occur in healthy people and are experienced occasionally by everyone. However, when they appear with more persistence and become more widespread they can be a sign of various neurological disorders. Hiccups are a kind of myoclonic jerk specifically affecting the diaphragm. When a spasm is caused by another person it is kn ...
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Homeostasis
In biology, homeostasis (British English, British also homoeostasis; ) is the state of steady internal physics, physical and chemistry, chemical conditions maintained by organism, living systems. This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits (homeostatic range). Other variables include the pH of extracellular fluid, the concentrations of sodium, potassium, and calcium ions, as well as the blood sugar level, and these need to be regulated despite changes in the environment, diet, or level of activity. Each of these variables is controlled by one or more regulators or homeostatic mechanisms, which together maintain life. Homeostasis is brought about by a natural resistance to change when already in optimal conditions, and equilibrium is maintained by many regulatory mechanisms; it is thought to be the central motivation for all organic action. All home ...
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Postanesthetic Shivering
Postanesthetic shivering (PAS) is shivering after anesthesia. Description and treatment Postanesthetic shivering is one of the leading causes of discomfort in patients recovering from general anesthesia. It usually results due to the anesthetic inhibiting the body's thermoregulatory capability, although cutaneous vasodilation (triggered by post-operative pain) may also be a causative factor. First-line treatment consists of warming the patient; more persistent/severe cases may be treated with medications such as tramadol, pethidine, clonidine, and nefopam, which work by reducing the shivering threshold temperature and reducing the patient's level of discomfort. As these medications may react and/or synergize with the anesthetic agents employed during the surgery, their use is generally avoided when possible. The anesthetic ketamine can also be used to manage postanesthetic shivering. Intensity The intensity of PAS may be graded using the scale described by Crossley and Mahajan: ...
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Brown Fat
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown adipose tissue is found in almost all mammals. Classification of brown fat refers to two distinct cell populations with similar functions. The first shares a common embryological origin with muscle cells, found in larger "classic" deposits. The second develops from white adipocytes that are stimulated by the sympathetic nervous system. These adipocytes are found interspersed in white adipose tissue and are also named 'beige' or 'brite' (for "brown in white"). Brown adipose tissue is especially abundant in newborns and in hibernating mammals. It is also present and metabolically active in adult humans, but its prevalence decreases as humans age. Its primary function is thermoregulation. In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. The therapeutic targeting of brown fat for the treatment o ...
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Chattering Teeth
Chattering teeth is a bodily function in animals that occurs primarily in response to cold; the jaw muscles begin to shiver leading teeth to crash together. It may also occur as a result of bruxism where emotional stress causes the jaw movements. Certain medications can lead to teeth chattering as a side effect, especially antipsychotics and selective serotonin reuptake inhibitor Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs primarily work by blo ...s. References Symptoms and signs Cold Teeth {{Symptom-stub ...
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Post Micturition Convulsion Syndrome
In neurourology, post-micturition convulsion syndrome (PMCS), also known informally as pee shivers or piss shivers, is the experience of shivering during or after urination. The syndrome seems to be experienced more often by men than women. The term "post-micturition convulsion syndrome" was coined in 1994 in the online question-and-answer newspaper column '' The Straight Dope'', when a reader inquired about the phenomenon. Explanation There has yet to be any peer-reviewed research on the topic. The most plausible theory is that the shiver is a result of the autonomic nervous system getting its signals mixed up between its two main divisions: *The sympathetic nervous system (SNS), which controls bladder function, preventing urination. *The parasympathetic nervous system (PNS), which relaxes the urethral sphincter and contracts the bladder, causing urination. Part of the SNS response to a full bladder is the release of catecholamines (including epinephrine, norepinephri ...
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Goose Bumps
Goose bumps, goosebumps or goose pimples are the bumps on a person's skin at the base of body hairs which may involuntarily develop when a person is Tickling, tickled, cold or experiencing strong emotions such as fear, euphoria or sexual arousal. The formation of goose bumps in humans under Stress (medicine), stress is considered by some to be a Vestigial response, vestigial reflex, though visible piloerection is associated with changes in skin temperature in humans. The reflex of producing goose bumps is known as piloerection or the pilomotor reflex, or, more traditionally, horripilation. It occurs in many mammals; a prominent example is porcupines, which raise their quills when threatened, or sea otters when they encounter sharks or other predators. Anatomy and biology Goose bumps are created when tiny muscles at the base of each hair, known as ''arrector pili muscles'', contract and pull the hair straight up. The reflex is started by the sympathetic nervous system, which i ...
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Psychogenic Shivering
Frisson ( , ; French for "shiver"), also known as aesthetic chills or psychogenic shivers, is a psychophysiological response to rewarding stimuli (including music, films, stories, people, photos, and rituals) that often induces a pleasurable or otherwise positively-valenced affective state and transient paresthesia (skin tingling or chills), sometimes along with piloerection (goose bumps) and mydriasis (pupil dilation). The sensation can occur as a mildly to moderately pleasurable emotional response to music with skin tingling. The psychological component (i.e., the pleasurable feeling) and physiological components (i.e., paresthesia, piloerection, and pupil dilation) of the response are mediated by the reward system and sympathetic nervous system, respectively. The stimuli that produce this response are specific to each individual. Frisson is of short duration, lasting only a few seconds. Typical stimuli include loud passages of music and passages—such as appoggiaturas a ...
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Adenosine Triphosphate
Adenosine triphosphate (ATP) is a nucleoside triphosphate that provides energy to drive and support many processes in living cell (biology), cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis. Found in all known forms of life, it is often referred to as the "molecular unit of currency" for intracellular energy transfer. When consumed in a Metabolism, metabolic process, ATP converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP. It is also a Precursor (chemistry), precursor to DNA and RNA, and is used as a coenzyme. An average adult human processes around 50 kilograms (about 100 mole (unit), moles) daily. From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the Polyphosphate, triphosphate. Structure ATP consists of three parts: a sugar, an amine base ...
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Proton Electromotive Force
An electrochemical gradient is a gradient of electrochemical potential, usually for an ion that can move across a membrane. The gradient consists of two parts: * The chemical gradient, or difference in solute concentration across a membrane. * The electrical gradient, or difference in charge across a membrane. If there are unequal concentrations of an ion across a permeable membrane, the ion will move across the membrane from the area of higher concentration to the area of lower concentration through simple diffusion. Ions also carry an electric charge that forms an electric potential across a membrane. If there is an unequal distribution of charges across the membrane, then the difference in electric potential generates a force that drives ion diffusion until the charges are balanced on both sides of the membrane. Electrochemical gradients are essential to the operation of batteries and other electrochemical cells, photosynthesis and cellular respiration, and certain other bi ...
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