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Sheila Singh
Sheila K. Singh MD, PhD, FRCSC is a chief pediatric neurosurgeon at McMaster Children's Hospital in Ontario, Canada. She is also Professor of Surgery and Biochemistry, the Division Head of Neurosurgery at Hamilton Health Sciences, the Research Director for McMaster's Division of Neurosurgery, and a scientist/principal investigator appointed to the Stem Cell and Cancer Research Institute at McMaster University. She holds a Tier 1/ Senior Canada Research Chair in Human Brain Cancer Stem Cell Biology, and is Director of the McMaster Surgeon Scientist Program (SSP), which is a part of McMaster's pre-established Clinical Investigator Program (CIP) that provides research training for surgical residents. Education Singh graduated from McGill University in 1994 with a bachelor's degree in neurobiology and molecular genetics, and from McMaster University with an MD in 1997. She subsequently trained in neurosurgery at the University of Toronto from 1997-2007 and completed a PhD i ...
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SickKids
The Hospital for Sick Children (HSC), corporately branded as SickKids, is a major pediatric teaching hospital located on University Avenue in Toronto, Ontario, Canada. Affiliated with the Faculty of Medicine of the University of Toronto, the hospital was ranked the top pediatric hospital in the world by Newsweek in 2021. The hospital's Peter Gilgan Centre for Research and Learning is believed to be the largest pediatric research tower in the world, at . History During 1875, an eleven-room house was rented for a year by a Toronto women's bible study group, led by Elizabeth McMaster. Opened on March 1, it set up six iron cots and "declared open a hospital 'for the admission and treatment of all sick children.'" The first patient, a scalding victim named Maggie, came in on April 3. In its first year, 44 patients were admitted to the hospital in its first year of operation, and 67 others were treated in outpatient clinics. In 1876, the hospital moved to larger facilities. In 189 ...
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European Society For Medical Oncology
The European Society for Medical Oncology (ESMO) is the leading professional organisation for medical oncology. With more than 25,000 members representing oncology professionals from over 160 countries worldwide, ESMO was founded in 1975. ''Annals of Oncology'' Founded in 1990, ESMO’s flagship scientific journal, ''Annals of Oncology'', publishes articles addressing medical oncology, surgery, radiotherapy, pediatric oncology, basic research and the comprehensive management of patients with malignant diseases. ''Annals of Oncology'' is the official journal of ESMO and from 2008 of the Japanese Society for Medical Oncology (JSMO) ESMO Clinical Practice Guidelines The ESMO Clinical Practice Guidelines (CPG) are intended to provide oncology professionals with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine. Each Clinical Practice Guideline includes information on the incidence of the malignancy, diagnostic criteria ...
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Mitacs
Mitacs is a nonprofit national research organization that, in partnerships with Canadian academia, private industry and government, operates research and training programs in fields related to industrial and social innovation. History Mitacs was founded by Canadian mathematicians in 1999. The organization, whose name originally stood for "Mathematics of Information Technology and Complex Systems", worked in the field of mathematical sciences and associated disciplines but has since expanded. In 2004, the Mitacs Accelerate program was launched and has since supported over 10,000 internships nationally.Joe Oliver (2015-04-21"Economic Action Plan 2015" ''Her Majesty the Queen in Right of Canada''. . https://www.ams.org/journals/notices/201908/rnoti-p1290.pdf Programs As of late 2020, Mitacs operates six main programs: Accelerate The organization's flagship program has supported over 10,000 research internships for graduate students and postdoctoral fellows since 2004 and has sinc ...
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Natural Sciences And Engineering Research Council
The Natural Sciences and Engineering Research Council of Canada (NSERC; french: Conseil de recherches en sciences naturelles et en génie du Canada, CRSNG) is the major federal agency responsible for funding natural sciences and engineering research in Canada. NSERC directly funds university professors and students as well as Canadian companies to perform research and training. With funding from the Government of Canada, NSERC supports the research of over 41,000 students, trainees and professors at universities and colleges in Canada with an annual budget of CA$1.1 billion in 2015. Its current director is Alejandro Adem. NSERC, combined with the Social Sciences and Humanities Research Council (SSHRC) and the Canadian Institutes of Health Research (CIHR), forms the major source of federal government funding to post-secondary research. These bodies are sometimes collectively referred to as the "Tri-Council" or "Tri-Agency". History NSERC came into existence on 1 May 1978 under th ...
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American Brain Tumor Association
The American Brain Tumor Association (ABTA), founded in 1973, was the first and is now the only national nonprofit organization in the United States dedicated to providing support services and programs to brain tumor patients and their families, as well as the funding of brain tumor research. The organization is headquartered in Chicago, Illinois, at 8550 W Bryn Mawr Avenue. The group's two founders were mothers of children who died from brain tumors. Services The American Brain Tumor Association provides: * A library of publications and resources covering general brain tumor information as well as tumor-specific and treatment-specific information * Phone and email-based supportive care provided by a licensed health-care professionals. * Funding for brain tumor research through a program that supports early career scientists and medical students, projects that transition laboratory science to actual patient treatment and care, discovery research, and data collection through the C ...
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Canadian Cancer Society
The Canadian Cancer Society (french: Société canadienne du cancer) is Canada's largest national cancer charity and the largest national charitable funder of cancer research in Canada. History The idea to form the Canadian Cancer Society originally came from the Saskatchewan Medical Association in 1929, when they formed Canada's first cancer committee. In 1937, the National Study Committee recommended the formation of new organization, which was later called Canadian Cancer Society for the Control of Cancer. The Canadian Cancer Society (CCS) was officially formed a decade later, in 1938, to educate Canadians about the early warning signs of cancer. At that time, many people did not seek medical help until their cancer had advanced past a treatable stage. In 1947, CCS began funding cancer research through the creation of the National Cancer Institute of Canada, an agreement between the Canadian Cancer Society and the Federal Department of Health and Welfare. The Society continu ...
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Ontario Institute For Cancer Research
The Ontario Institute for Cancer Research (OICR) is a not-for-profit organization based in Toronto, Ontario, Canada that focuses on the prevention, early detection, diagnosis and treatment of cancer. OICR intends to make Ontario more effective in knowledge transfer and commercialization while maximizing the health and economic benefits of research findings for the people of Ontario. OICR was launched in 2005 by the Government of Ontario, which provides funding through the Ministry of Colleges and Universities. The Institute employs more than 300 people at its research hub at the MaRS Centre in downtown Toronto and funds more than 1,900 scientific staff at hospital-based research institutes and universities around the province. In 2018 it was the highest funder of cancer research in Canada. History Ontario Cancer Research Network OICR’s predecessor organization was the Ontario Cancer Research Network (OCRN), a not-for-profit corporation established by the Government of Onta ...
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Micrometastasis
A micrometastasis is a small collection of cancer cells that has been shed from the original tumor and spread to another part of the body through the lymphovascular system. Micrometastases are too few, in size and quantity, to be picked up in a screening or diagnostic test, and therefore cannot be seen with imaging tests such as a mammogram, MRI, ultrasound, PET, or CT scans. These migrant cancer cells may group together to form a second tumor, which is so small that it can only be seen under a microscope. Approximately ninety percent of people who die from cancer die from metastatic disease, since these cells are so challenging to detect. It is important for these cancer cells to be treated immediately after discovery, in order to prevent the relapse (regrowth of the cancer) and the likely death of the patient. Detection of micrometastatic cells The major concern with micrometastases is that the only way to determine if they are present in distant tissue is to remove cells from wh ...
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Brain Metastases
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. The metastasis typically shares a cancer cell type with the original site of the cancer. Metastasis is the most common cause of brain cancer, as primary tumors that originate in the brain are less common. The most common sites of primary cancer which metastasize to the brain are lung, breast, colon, kidney, and skin cancer. Brain metastases can occur in patients months or even years after their original cancer is treated. Brain metastases have a poor prognosis for cure, but modern treatments are allowing patients to live months and sometimes years after the diagnosis. Symptoms and signs Because different parts of the brain are responsible for different functions, symptoms vary depending on the site of metastasis within the brain. However, brain metastases should be considered in any cancer patient who presents with neu ...
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Glioblastomas
Glioblastoma, previously known as glioblastoma multiforme (GBM), is one of the most aggressive types of cancer that begin within the brain. Initially, signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Symptoms often worsen rapidly and may progress to unconsciousness. The cause of most cases of glioblastoma is not known. Uncommon risk factors include genetic disorders, such as neurofibromatosis and Li–Fraumeni syndrome, and previous radiation therapy. Glioblastomas represent 15% of all brain tumors. They can either start from normal brain cells or develop from an existing low-grade astrocytoma. The diagnosis typically is made by a combination of a CT scan, MRI scan, and tissue biopsy. There is no known method of preventing the cancer. Treatment usually involves surgery, after which chemotherapy and radiation therapy are used. The medication temozolomide is frequently used as ...
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Medulloblastomas
Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. The brain is divided into two main parts, the larger cerebrum on top and the smaller cerebellum below towards the back. They are separated by a membrane called the tentorium. Tumors that originate in the cerebellum or the surrounding region below the tentorium are, therefore, called infratentorial. Historically medulloblastomas have been classified as a primitive neuroectodermal tumor (PNET), but it is now known that medulloblastoma is distinct from supratentorial PNETs and they are no longer considered similar entities. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. Metastasis all the way d ...
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Cancer Research
Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy. Cancer research is done in academia, research institutes, and corporate environments, and is largely government funded. History Cancer research has been ongoing for centuries. Early research focused on the causes of cancer. Percivall Pott identified the first environmental trigger (chimney soot) for cancer in 1775 and cigarette smoking was identif ...
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