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Scedosporium Prolificans
''Lomentospora prolificans'' is an emerging opportunistic fungal pathogen that causes a wide variety of infections in immunologically normal and immunosuppressed people and animals. It is resistant to most antifungal drugs and infections are often fatal. Drugs targeting the Dihydroorotate dehydrogenase (quinone), Class II dihydroorotate dehydrogenase (DHODH) proteins of ''L. prolificans'', ''Scedosporium'', ''Aspergillus'' and other rare moulds are the basis for at least one new therapy, Olorofim, which is currently in phase 2b clinical trials and has received breakthrough status by FDA. For information on all DHODH proteins, please see Dihydroorotate dehydrogenase. History The genus ''Lomentospora'' was erected by G. Hennebert and B.G. Desai in 1974 to accommodate a culture obtained from greenhouse soil originating from a forest in Belgium. The fungus, which they named ''Lomentospora prolificans'', was thought incorrectly to be related to the genus ''Beauveria'' - a group of insec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungi
A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related organisms, named the ''Eumycota'' (''t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albaconazole
Albaconazole (development code UR-9825) is an experimental triazole antifungal. It has potential broad-spectrum activity. The drug blocks a number of CYP450 liver enzymes. It has also been studied as an antiprotozoal Antiprotozoal agents ( ATC code: ATC P01) is a class of pharmaceuticals used in treatment of protozoan infection. A paraphyletic group, protozoans have little in common with each other. For example, ''Entamoeba histolytica'', a unikont eukaryot ... agent. References Chloroarenes Fluoroarenes Lactams Lanosterol 14α-demethylase inhibitors Phenylethanolamines Quinazolines Tertiary alcohols Triazole antifungals {{antiinfective-agent-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miltefosine
Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as ''Naegleria fowleri'' and ''Balamuthia mandrillaris''. This includes the three forms of leishmaniasis: cutaneous, visceral and mucosal. It may be used with liposomal amphotericin B or paromomycin. It is taken by mouth. Common side effects include vomiting, abdominal pain, fever, headaches, and decreased kidney function. More severe side effects may include Stevens–Johnson syndrome or low blood platelets. Use during pregnancy appears to cause harm to the baby and use during breastfeeding is not recommended. How it works is not entirely clear. Miltefosine was first made in the early 1980s and studied as a treatment for cancer. A few years later it was found to be useful for leishmaniasis and was approved for this use in 2002 in India. It is on the World Health Organization's List of Essential Medicines. Medical uses Leishma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Posaconazole
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. It was approved for medical use in the United States in September 2006, and is available as a generic medication. Medical uses Posaconazole is used to treat invasive ''Aspergillus'' and '' Candida'' infections. It is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy. It is also used to treat invasive infections by ''Candida'', ''Mucor'', and ''Aspergillus'' species in severely immunocompromised patients. Clinical evidence for its utility in treatment of invasive disease caused by ''Fusarium'' species (fusariosis) is limited. It appears to be helpful in a mouse model of naegleriasis. Pharmacology Pharmacodynamics Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the el ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Terbinafine
Terbinafine, sold under the brand name Lamisil among others, is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. It is either taken by mouth or applied to the skin as a cream or ointment. The cream and ointment are not effective for nail infections. Common side effects when taken by mouth include nausea, diarrhea, headache, cough, rash, and elevated liver enzymes. Severe side effects include liver problems and allergic reactions. Liver injury is, however, unusual. Use during pregnancy is not typically recommended. The cream and ointment may result in itchiness but are generally well tolerated. Terbinafine is in the allylamines family of medications. It works by decreasing the ability of fungi to synthesize sterols. It appears to result in fungal cell death. Terbinafine was discovered in 1991. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 279th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Voriconazole
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by ''Scedosporium'' or ''Fusarium''. It can be taken by mouth or used by injection into a vein. Common side effects include vision problems, nausea, abdominal pain, rash, headache, and seeing or hearing things that are not present. Use during pregnancy may result in harm to the baby. It is in the triazole family of medications. It works by affecting fungal metabolism and fungal cell membranes. Voriconazole was patented in 1990 and approved for medical use in the United States in 2002. It is on the World Health Organization's List of Essential Medicines. Medical uses Voriconazole is used to treat invasive aspergillosis and candidiasis and fungal infections caused by ''Scedosporium'' and ''Fusarium'' species, which may occur in immunocomprom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schefflera Actinophylla
''Heptapleurum actinophyllum'' (formerly ''Schefflera actinophylla'') is a tree in the family Araliaceae. It is native to tropical rainforests and gallery forests in northern and north-eastern Queensland coasts and the Northern Territory of Australia, as well as New Guinea and Java. Common names include Australian umbrella tree, Queensland umbrella tree, octopus tree and amate. Description ''Heptapleurum actinophyllum'' is an evergreen tree growing to tall. It has palmately compound medium green leaves in groups of seven leaflets. It is usually multi-trunked, and the flowers develop at the top of the tree. It often grows as a hemiepiphyte on other rainforest trees. It produces racemes up to long containing up to 1,000 small red flowers. Flowering begins in early summer and typically continues for several months. The specific epithet ''actinophyllum'' means "with radiating leaves". Ecology The up to 1,000 flowers produced by the plant generate large amounts of nectar, attractin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ficus Benjamina
''Ficus benjamina'', commonly known as weeping fig, benjamin fig or ficus tree, and often sold in stores as just ficus, is a species of flowering plant in the family Moraceae, native to Asia and Australia. It is the official tree of Bangkok. The species is also naturalized in the West Indies and in the states of Florida and Arizona in the United States. In its native range, its small fruit are favored by some birds. Description ''Ficus benjamina'' is a tree reaching tall in natural conditions, with gracefully drooping branchlets and glossy leaves , oval with an acuminate tip. The bark is light gray and smooth. The bark of young branches is brownish. The widely spread, highly branching tree top often covers a diameter of 10 meters. It is a relatively small-leaved fig. The changeable leaves are simple, entire and stalked. The petiole is long. The young foliage is light green and slightly wavy, the older leaves are green and smooth; the leaf blade is ovate to ovate-lanceolate wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scedosporium Apiospermum
''Pseudallescheria boydii'' is a species of fungus classified in the Ascomycota. It is associated with some forms of eumycetoma/ maduromycosis and is the causative agent of pseudallescheriasis. Typically found in stagnant and polluted water, it has been implicated in the infection of immunocompromised and near-drowned pneumonia patients. Treatment of infections with ''P. boydii'' is complicated by resistance to many of the standard antifungal agents normally used to treat infections by filamentous fungi. ''Pseudallescheria boydii'' fungal infection was the cause of death in three athletes submerged in the Yarkon River after a bridge collapsed during the 1997 Maccabiah Games. Taxonomy The fungus was originally described by American mycologist Cornelius Lott Shear in 1922 as a species of '' Allescheria''. Shear obtained cultures from a patient of the Medical Department of the University of Texas. The microbe was apparently associated with a penetrating thorn the patient ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synonym (taxonomy)
The Botanical and Zoological Codes of nomenclature treat the concept of synonymy differently. * In botanical nomenclature, a synonym is a scientific name that applies to a taxon that (now) goes by a different scientific name. For example, Linnaeus was the first to give a scientific name (under the currently used system of scientific nomenclature) to the Norway spruce, which he called ''Pinus abies''. This name is no longer in use, so it is now a synonym of the current scientific name, ''Picea abies''. * In zoology, moving a species from one genus to another results in a different binomen, but the name is considered an alternative combination rather than a synonym. The concept of synonymy in zoology is reserved for two names at the same rank that refers to a taxon at that rank - for example, the name ''Papilio prorsa'' Linnaeus, 1758 is a junior synonym of ''Papilio levana'' Linnaeus, 1758, being names for different seasonal forms of the species now referred to as ''Araschnia le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scedosporium
''Scedosporium'' is a genus (biology), genus of fungi in the family Microascaceae. The genus shed the alternative name ''Pseudallescheria'' as the "One Fungus, One Name" principle overtook the previous dual naming system, which had a distinct names for the anamorph and teleomorph. Species and species complexes The following are based on Ramirez-Garcia ''et al.'', 2018 * ''Scedosporium apiospermum'' Species complex ** ''Scedosporium angustum'' ** ''Scedosporium apiospermum'' ** ''Scedosporium boydii'' Species complex ** ''Scedosporium ellipsoideum'' ** ''Scedosporium fusarium'' * ''Scedosporium prolificans'' * ''Scedosporium aurantiacum'' * ''Scedosporium minutisporum'' * ''Scedosporium desertorum'' * ''Scedosporium cereisporum'' * ''Scedosporium dehoogii'' Species complex See also * Scedosporiosis * ''Pseudallescheria'' References Microascales {{Microascales-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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