Sarah Stewart (cancer Researcher)
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Sarah Stewart (cancer Researcher)
Sarah Elizabeth Stewart (August 16, 1905 – November 27, 1976) was a Mexican-American researcher who pioneered the field of viral oncology research, and the first to show that cancer-causing viruses can spread from animal to animal. She and Bernice Eddy co-discovered the first polyoma virus, and SE (Stewart-Eddy) polyoma virus is named after them. Personal life and education Early life Sarah Elizabeth Stewart was born on August 16, 1905, in Tecalitlán, Jalisco, Mexico, to a Native Mexican mother and an American mining engineer father. Due to the Mexican Revolution, her and her family were asked to leave the country in 1911, forcing them to migrate to the United States. Stewart would continue to speak Spanish fluently throughout her lifetime. Stewart and her family lived in Cottage Grove, Oregon, where she completed her lower education. Education In 1927, she graduated with a Bachelors of Science and a degree in economics from New Mexico State University. She went on ...
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Tecalitlán
Tecalitlán is a city and municipality in the central Pacific coastal state of Jalisco, Mexico. Located just south of Ciudad Guzmán, its population was 16,705 as of 2020. Industry One of Tecalitlán's major industries was the growing of sugar cane. This industry ended about thirty years ago. Nowadays the economy comes from agriculture and the raising of animals such as cattle, pigs, chickens, and goats. Many families of emigrants in the United States receive substantial money from them. Culture Tecalitlán is at the heart of the region where mariachi music was developed, and in fact the most famous exponent of that genre, Vargas de Tecalitlán, was founded there in the 1890s (though now resident in Mexico City). There is a museum of this mariachi in Tecalitlan. Tecalitlan has many traditions, such as the fiestas de diciembre which celebrate religion and the love toward the Virgin of Guadalupe. People in this town are very friendly. A very interesting tradition kept until now ...
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Microbiology
Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, protistology, mycology, immunology, and parasitology. Eukaryotic microorganisms possess membrane-bound organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include Bacteria and Archaea. Microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means. Microbiologists often rely on molecular biology tools such as DNA sequence based identification, for example the 16S rRNA gene sequence used for bacteria identification. Viruses have been variably classified as organisms, as they have ...
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Jonas Salk
Jonas Edward Salk (; born Jonas Salk; October 28, 1914June 23, 1995) was an American virologist and medical researcher who developed one of the first successful polio vaccines. He was born in New York City and attended the City College of New York and New York University School of Medicine. In 1947, Salk accepted a professorship in the School of Medicine at the University of Pittsburgh. It was there that he undertook a project to determine the number of different types of poliovirus, starting in 1948. For the next seven years, Salk devoted himself towards developing a vaccine against polio. Salk was immediately hailed as a "miracle worker" when the vaccine's success was first made public in April 1955, and chose to not patent the vaccine or seek any profit from it in order to maximize its global distribution. The National Foundation for Infantile Paralysis and the University of Pittsburgh looked into patenting the vaccine but, since Salk's techniques were not novel, their paten ...
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Burkitt's Lymphoma Virus
Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa. The overall cure rate for Burkitt lymphoma in developed countries is about 90%, and it is worse in low-income countries. Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis. Classification Burkitt lymphoma can be divided into three main clinical variants: the endemic, the sporadic, and the immunodeficiency-associated variants. By morphology (i.e., microscopic appearance), immunophenotype, and genetics, the variants of Burkitt lymphoma are alike. * The endemic variant (also called "African variant") most commonly occurs in children living in malaria-endemic regions of the world (e.g., equatorial Africa, Brazil, and Papua New Guinea). Epstein–Barr virus (EBV) infection is found in nearly all patients. Chronic malari ...
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American Association For The Advancement Of Science
The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the betterment of all humanity. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal ''Science''. History Creation The American Association for the Advancement of Science was created on September 20, 1848, at the Academy of Natural Sciences in Philadelphia, Pennsylvania. It was a reformation of the Association of American Geologists and Naturalists. The society chose William Charles Redfield as their first president because he had proposed the most comprehensive plans for the organization. According to the first constitution which was agreed to at the September 20 meeting, the goal of ...
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Ludwik Gross
Ludwik Gross (September 11, 1904 – July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses—murine leukemia virus and mouse polyomavirus—capable of causing cancers in laboratory mice. Biography Gross was born on September 11, 1904 in Kraków, Poland to a prominent Jewish family. He studied for a degree in medicine at the Jagiellonian University. He escaped from occupied Poland in 1940 soon after the 1939 Nazi invasion and travelled to the United States, ultimately serving in the United States Armed Forces during World War II. After the war, he joined other scientists (notably Rosalyn Yalow, recipient of the 1977 Nobel Prize in Medicine or Physiology) in the "Golden Age" of research at the Bronx Veterans Administration Medical Center, becoming director of the Cancer Research Division. One story claims that this appointment allowed him to move his research mice from the trunk of his car, where he had been carrying out studies, into a fully ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ...
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Ludwig Gross
Ludwik Gross (September 11, 1904 – July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses—murine leukemia virus and mouse polyomavirus—capable of causing cancers in laboratory mice. Biography Gross was born on September 11, 1904 in Kraków, Poland to a prominent Jewish family. He studied for a degree in medicine at the Jagiellonian University. He escaped from occupied Poland in 1940 soon after the 1939 Nazi invasion and travelled to the United States, ultimately serving in the United States Armed Forces during World War II. After the war, he joined other scientists (notably Rosalyn Yalow, recipient of the 1977 Nobel Prize in Medicine or Physiology) in the "Golden Age" of research at the Bronx Veterans Administration Medical Center, becoming director of the Cancer Research Division. One story claims that this appointment allowed him to move his research mice from the trunk of his car, where he had been carrying out studies, into a fully ...
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Polyomavirus
''Polyomaviridae'' is a family of viruses whose natural hosts are primarily mammals and birds. As of 2020, there are six recognized genera and 117 species, five of which are unassigned to a genus. 14 species are known to infect humans, while others, such as Simian Virus 40, have been identified in humans to a lesser extent. Most of these viruses are very common and typically asymptomatic in most human populations studied. BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients, JC virus with progressive multifocal leukoencephalopathy, and Merkel cell virus with Merkel cell cancer. Structure and genome Polyomaviruses are non-enveloped double-stranded DNA viruses with circular genomes of around 5000 base pairs. The genome is packaged in a viral capsid of about 40-50 nanometers in diameter, which is icosahedral in shape (T=7 symmetry). The capsid is composed of 72 pentameric capsomeres of a protein called VP1, which is capabl ...
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National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding each ...
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World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ...
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