Salvia Pachyphylla
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Salvia Pachyphylla
''Salvia pachyphylla'' (the rose sage, blue sage, or mountain desert sage) is a perennial shrub native to California, Nevada, and Arizona. In California, it grows between elevation on dry rocky slopes, blooming from July to September. It reaches high, with blue-violet flowers, rarely rose, growing in dense clusters. In the course of a study of the chemical composition of the flora used in Latin American traditional medicine, Ivan C. Guerrero and coworkers have performed phytochemical studies of extracts of the aerial parts from ''Salvia pachyphylla'' and '' Salvia clevelandii ''. The major secondary metabolites were isolated from these species and the ''in vitro'' cytotoxic effects against five human cancer cells were reported for eight of the compounds obtained: carnosol, rosmanol, 20-deoxocarnosol, carnosic acid Carnosic acid is a natural benzenediol abietane diterpene found in rosemary (''Rosmarinus officinalis'') and common sage (''Salvia officinalis''). Dried leaves ...
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Epling
Carl Clawson Epling (15 April 1894 – 17 November 1968) was an American botanist and taxonomist. He is best known for being the major authority on the Lamiaceae (mint family) of the Americas from the 1920s to the 1960s. In his later years he also developed an interest in genetics. University of California: In Memoriam − Carl Clawson Epling, Botany: UC Los Angeles
December 1970.


History

Epling obtained his B.A. from the College of Agriculture at in 1921. He received his M.A. in 1923 and Ph.D. in 1924 from

Pachyphyllone Structure
Pachyphyllone is a diterpenoid of the abietane class found in the herb In general use, herbs are a widely distributed and widespread group of plants, excluding vegetables and other plants consumed for macronutrients, with savory or aromatic properties that are used for flavoring and garnishing food, for medicinal ... mountain desert sage (''Salvia pachyphylla''). See also * List of phytochemicals in food References Ketones Salvia {{ketone-stub ...
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Traditional Medicine
Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the era of modern medicine. The World Health Organization (WHO) defines traditional medicine as "the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness". Traditional medicine is often contrasted with scientific medicine. In some Asian and African countries, up to 80% of the population relies on traditional medicine for their primary health care needs. When adopted outside its traditional culture, traditional medicine is often considered a form of alternative medicine. Practices known as traditional medicines ...
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Salvia Clevelandii
''Salvia clevelandii'', the fragrant sage, blue sage, Jim sage and Cleveland sage, is a perennial plant that is native to Southern California and northern Baja California, growing below elevation in California coastal sage and chaparral habitat. The plant was named in 1874 by Asa Gray, honoring plant collector Daniel Cleveland. Description ''Salvia clevelandii'' is an evergreen shrub that reaches in height and width. The fragrant, ashy green leaves are obovate and rugose, growing less than long. Flowers are on spikes, with numerous whorls of upright amethyst blooms opening in June–July. Phytochemistry The rose potpourri scented foliage of hybrids is composed of camphor and 1,8-cineole. Named cultivars with a eucalyptus scent also contain around 20% 1,8-cineole. Taxonomy This species was described in 1874 as ''Audibertia clevelandii'' (the basionym) by Asa Gray, named in honor of Daniel Cleveland. Cleveland was an amateur botanist and civic leader from San Dieg ...
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In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ...
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Cytotoxic
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa''). Cell physiology Treating cells with the cytotoxic compound can result in a variety of cell fates. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. The cells can stop actively growing and dividing (a decrease in cell viability), or the cells can activate a genetic program of controlled cell death (apoptosis). Cells undergoing necrosis typically exhibit rapid swelling, lose membrane integrity, shut down metabolism, and release their contents into the environment. Cells that undergo rapid necrosis in vitro do not have sufficient time or energy to activate apoptotic machinery and will not express apoptotic markers. Apoptosis is characterized by well defined cytological and molecular events including a change i ...
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