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Salinomycin
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Antibacterial activity Salinomycin and its derivatives exhibit high antimicrobial activity against Gram-positive bacteria, including the most problematic bacteria strains such as methicillin-resistant ''Staphylococcus aureus'' and methicillin-resistant ''Staphylococcus epidermidis'', and ''Mycobacterium tuberculosis''. Salinomycin is inactive against fungi such as ''Candida'' and Gram-negative bacteria. Cancer research Pre-clinical Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse. The mechanism of action by which salinomyci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Narasin
Narasin is a coccidiostat and antibacterial agent. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of ''Streptomyces aureofaciens ''Kitasatospora aureofaciens'' is a species of ''Kitasatospora'', and the source of many tetracycline antibiotics. The organism was first isolated at Sanborn Field on the University of Missouri campus in Columbia, Missouri, US; the site became a ...''. References Antibiotics Antiparasitic agents Carboxylic acids Secondary alcohols Tertiary alcohols Ketones Tetrahydropyrans Tetrahydrofurans Spiro compounds Ketals {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Stem Cells
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. However, animals do not provide a complete m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ionophore
In chemistry, an ionophore () is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). Structurally, an ionophore contains a hydrophilic center and a hydrophobic portion that interacts with the membrane. Some ionophores are synthesized by microorganisms to import ions into their cells. Synthetic ion carriers have also been prepared. Ionophores selective for cations and anions have found many applications in analysis. These compounds have also shown to have various biological effects and a synergistic effect when combined with the ion they bind. Classification Biological activities of metal ion-binding compounds can be changed in response to the increment of the metal concentrati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (journal)
''Cell'' is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. The journal was established in 1974 by Benjamin LewinElsevier: ''Cell'': Home (accessed 12 December 2008) and is published twice monthly by , an imprint of |
Polyketide Synthase
Polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (or reduced forms of a ketone) and methylene groups: (-CO-CH2-). First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by heating dehy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyketide
Polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (or reduced forms of a ketone) and methylene groups: (-CO-CH2-). First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by heating dehy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ChemBioChem
''ChemBioChem'' is a peer-reviewed scientific journal covering chemical biology, synthetic biology, and bio-nanotechnology and published by Wiley-VCH on behalf of Chemistry Europe. The journal publishes communications, full papers, reviews, minireviews, highlights, concepts, book reviews, and conference reports. Viewpoints, correspondence, essays, web sites, and databases are also occasionally featured. It is abstracted and indexed in major databases and has been online-only since 2016. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 3.461. References External links * Chemistry Europe academic journals Publications established in 2000 Biochemistry journals English-language journals On ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces Albus
{{Streptomyces-stub ...
''Streptomyces albus'' is a bacterial species from which the pseudodisaccharide aminoglycoside salbostatin was isolated. ''S. albus'' is known to produce white aerial mycelium. References Further reading * External linksType strain of ''Streptomyces albus'' at Bac''Dive'' - the Bacterial Diversity Metadatabase albus Albus may refer to: * Albus (surname) * Albinus (cognomen), or Albus, a Latin surname * Albus (coin), ''groschen'' coin of the Holy Roman Empire * Albus, a Geomantic figure * 'Albus', a cultivar of Rosemary Entertainment * Albus Dumbledore ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cambridge
, mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Scholars of the University of Cambridge , type = Public research university , endowment = £7.121 billion (including colleges) , budget = £2.308 billion (excluding colleges) , chancellor = The Lord Sainsbury of Turville , vice_chancellor = Anthony Freeling , students = 24,450 (2020) , undergrad = 12,850 (2020) , postgrad = 11,600 (2020) , city = Cambridge , country = England , campus_type = , sporting_affiliations = The Sporting Blue , colours = Cambridge Blue , website = , logo = University of Cambridge logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-Cancer Agents In Medicinal Chemistry
''Anti-Cancer Agents in Medicinal Chemistry'' is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori ( "G. d'Annunzio" University of Chieti-Pescara). The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers. It is related to the journal ''Current Medicinal Chemistry'' and was established in 2001 as ''Current Medicinal Chemistry – Anti-Cancer Agents''. The journal obtained its present title in 2006. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioorganic & Medicinal Chemistry Letters
''Bioorganic & Medicinal Chemistry Letters'' is a scientific journal focusing on the results of research on the molecular structure of biological organisms and the interaction of biological targets with chemical agents. It is published by Elsevier, which also publishes ''Bioorganic & Medicinal Chemistry ''Bioorganic & Medicinal Chemistry'' is a scientific journal focusing on the results of research on the molecular structure of biological organisms and the interaction of biological targets with chemical agents.Bioorganic & Medicinal Chemistry' It ...'' for longer works. Biochemistry journals Elsevier academic journals English-language journals Medicinal chemistry journals {{biochem-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Biomedicine And Biotechnology
''BioMed Research International'' is a peer-reviewed open access scientific journal covering all aspects of biomedical sciences. It was established in 2001 as the ''Journal of Biomedicine and Biotechnology'' with Abdelali Haoudi as first editor-in-chief (until 2008). The journal obtained its current title in 2013 and is published by Hindawi Publishing Corporation. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2014 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 1.579, and in 2016 its ranking was 65/158 of Biotechnology & Applied Microbiology. References External links * Hindawi Publishing Corporation academic journals Publications established in 2001 Open access jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
