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Saccharopolyspora Spinosa
''Saccharopolyspora spinosa'' is a species of actinobacterium first isolated from soil in a rum still in an abandoned sugar mill on the Virgin Islands. It was discovered and described by researchers Mertz and Yao while collecting specimens to be screened for novel antibiotics. It develops aerial, pale, yellowish pink hyphae and bears long chains of spores encased in spiny spore sheaths. It can also reproduce by fragmentation in an aqueous environment. Its type strain is A83543.1 (= NRRL 18395). ''Saccharopolyspora spinosa'' is the source of a family of insecticidal compounds called spinosyns. They act as neurotoxins by activation of nicotinic acetylcholine receptors in insects. The insecticide Spinetoram is composed of two synthetic derivatives of spinosyns. See also *Spinosad Spinosad is an insecticide based on chemical compounds found in the bacterial species ''Saccharopolyspora spinosa''. The genus ''Saccharopolyspora'' was discovered in 1985 in isolates from crushed su ...
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Virgin Islands
The Virgin Islands ( es, Islas Vírgenes) are an archipelago in the Caribbean Sea. They are geologically and biogeographically the easternmost part of the Greater Antilles, the northern islands belonging to the Puerto Rico Trench and St. Croix being a displaced part of the same geologic structure. Politically, the British Virgin Islands have been governed as the western island group of the Leeward Islands, which are the northern part of the Lesser Antilles, and form the border between the Caribbean Sea and the Atlantic Ocean. The archipelago is separated from the true Lesser Antilles by the Anegada Passage and from the main island of Puerto Rico by the Virgin Passage. The islands fall into three different political jurisdictions: * Virgin Islands, informally referred to as British Virgin Islands, a British overseas territory, * Virgin Islands of the United States, an unincorporated territory of the United States, * Spanish Virgin Islands, the easternmost islands of the Comm ...
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Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) ...
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Hyphae
A hypha (; ) is a long, branching, filamentous structure of a fungus, oomycete, or actinobacterium. In most fungi, hyphae are the main mode of vegetative growth, and are collectively called a mycelium. Structure A hypha consists of one or more cells surrounded by a tubular cell wall. In most fungi, hyphae are divided into cells by internal cross-walls called "septa" (singular septum). Septa are usually perforated by pores large enough for ribosomes, mitochondria, and sometimes nuclei to flow between cells. The major structural polymer in fungal cell walls is typically chitin, in contrast to plants and oomycetes that have cellulosic cell walls. Some fungi have aseptate hyphae, meaning their hyphae are not partitioned by septa. Hyphae have an average diameter of 4–6 µm. Growth Hyphae grow at their tips. During tip growth, cell walls are extended by the external assembly and polymerization of cell wall components, and the internal production of new cell membrane. ...
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Spore
In biology, a spore is a unit of sexual or asexual reproduction that may be adapted for dispersal and for survival, often for extended periods of time, in unfavourable conditions. Spores form part of the life cycles of many plants, algae, fungi and protozoa. Bacterial spores are not part of a sexual cycle, but are resistant structures used for survival under unfavourable conditions. Myxozoan spores release amoeboid infectious germs ("amoebulae") into their hosts for parasitic infection, but also reproduce within the hosts through the pairing of two nuclei within the plasmodium, which develops from the amoebula. In plants, spores are usually haploid and unicellular and are produced by meiosis in the sporangium of a diploid sporophyte. Under favourable conditions the spore can develop into a new organism using mitotic division, producing a multicellular gametophyte, which eventually goes on to produce gametes. Two gametes fuse to form a zygote which develops into a new s ...
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Fragmentation (reproduction)
Fragmentation in multicellular or colonial organisms is a form of asexual reproduction or cloning, where an organism is split into fragments. Each of these fragments develops into mature, fully grown individuals that are clones of the original organism. The organism may develop specific organs or zones to shed or be easily broken off. If the splitting occurs without the prior preparation of the organism, both fragments must be able to regenerate the complete organism for it to function as reproduction. Fragmentation as a method of reproduction is seen in organisms such as filamentous cyanobacteria, molds, lichens, sponges, acoel flatworms, some annelid worms and sea stars. Fragmentation in various organisms Molds, yeasts and mushrooms, all of which are part of the Fungi kingdom, produce tiny filaments called hyphae. These hyphae obtain food and nutrients from the body of other organisms to grow and fertilize. Then a piece of hyphae breaks off and grows into a new individual ...
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Spinosad
Spinosad is an insecticide based on chemical compounds found in the bacterial species ''Saccharopolyspora spinosa''. The genus ''Saccharopolyspora'' was discovered in 1985 in isolates from crushed sugarcane. The bacteria produce yellowish-pink aerial hyphae, with bead-like chains of spores enclosed in a characteristic hairy sheath. This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. ''S. spinosa'' was isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. Spinosad is a mixture of chemical compounds in the spinosyn family that has a generalized structure consisting of a unique tetracyclic ring system attached to an amino sugar (D-forosamine) and a neutral sugar (tri-''Ο''-methyl-L-rhamnose). Spinosad is relatively nonpolar and not easily dissolved in water. Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of ''S ...
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Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system. The nicotinic receptors are considered cholinergi ...
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Spinetoram
Spinetoram (marketed as Cheristin in its topical veterinary dosage-form) is an insecticidal mixture of two active neurotoxic constituents of ''Saccharopolyspora spinosa''. It is used to control pest insects in stored grain and on domestic cats. See also *Spinosad Spinosad is an insecticide based on chemical compounds found in the bacterial species ''Saccharopolyspora spinosa''. The genus ''Saccharopolyspora'' was discovered in 1985 in isolates from crushed sugarcane. The bacteria produce yellowish-pink ae ... References {{reflist Insecticides ...
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Pseudonocardineae
The Pseudonocardiaceae are a family of bacteria in the order Actinomycetales and the only member of the suborder Pseudonocardineae. Genomics The species within the family Pseudonocardiaceae form a distinct clade in phylogenetic trees based on concatenated protein sequences. Additionally, ''Nakamurella multipartite'', currently part of the order Frankiales, also formed a clade with the Pseudonocardiaceae species in 100% of the bootstrap replications of the phylogenetic trees. A conserved signature indel has been identified which is found in ''N. multipartite'' and all but one of the Pseudonocardiaceae species. This one-amino-acid insertion in UMP kinase serves to both provide a molecular marker for nearly all of the Pseudonocardiaceae and suggests ''N. multipartite'' is closely related to this group. Some evidence also suggests the orders Pseudonocardiales and Corynebacteriales are closely related. Several conserved signature indels have been identified which are found in both ...
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