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Rudolph Peters
Sir Rudolph Albert Peters MC MID FRS H FRSE FRCP LLD (13 April 1889 – 29 January 1982) was a British biochemist. He led the research team at Oxford who developed British Anti-Lewisite (BAL), an antidote for the chemical warfare agent lewisite. His efforts investigating the mechanism of arsenic war gases were deemed crucial in maintaining battlefield effectiveness. Life He was born in Kensington in London the son of Dr Albert E. D. R. Peters (1863-1945), a physician, and his wife, Agnes Malvina Watts (1867-1950). He was educated at Wellington College, Berkshire, then studied Medicine at King's College London and Gonville and Caius College, Cambridge. In the First World War he served in the Royal Army Medical Corps as Medical Officer to the 60th Rifles. From 1917 he was attached to the chemical warfare section at Porton Down. After the war he returned to Cambridge University lecturing in Biochemistry. In 1923 he was created Professor of Biochemistry at Oxford University. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kensington
Kensington is a district in the Royal Borough of Kensington and Chelsea in the West End of London, West of Central London. The district's commercial heart is Kensington High Street, running on an east–west axis. The north-east is taken up by Kensington Gardens, containing the Albert Memorial, the Serpentine Gallery and John Hanning Speke, Speke's monument. South Kensington and Gloucester Road, London, Gloucester Road are home to Imperial College London, the Royal College of Music, the Royal Albert Hall, Natural History Museum, London, Natural History Museum, Victoria and Albert Museum, and Science Museum, London, Science Museum. The area is also home to many embassies and consulates. Name The Manorialism, manor of ''Chenesitone'' is listed in the Domesday Book of 1086, which in the Old English language, Anglo-Saxon language means "Chenesi's List of generic forms in place names in Ireland and the United Kingdom, ton" (homestead/settlement). One early spelling is ''Kesyngton ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University
Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the University of Oxford, the oldest university in the English-speaking world; it has buildings in every style of English architecture since late Anglo-Saxon. Oxford's industries include motor manufacturing, education, publishing, information technology and science. History The history of Oxford in England dates back to its original settlement in the Saxon period. Originally of strategic significance due to its controlling location on the upper reaches of the River Thames at its junction with the River Cherwell, the town grew in national importance during the early Norman period, and in the late 12th century became home to the fledgling University of Oxford. The city was besieged during The Anarchy in 1142. The university rose to domina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1982 Deaths
__NOTOC__ Year 198 (CXCVIII) was a common year starting on Sunday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Sergius and Gallus (or, less frequently, year 951 ''Ab urbe condita''). The denomination 198 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire *January 28 **Publius Septimius Geta, son of Septimius Severus, receives the title of Caesar. **Caracalla, son of Septimius Severus, is given the title of Augustus. China *Winter – Battle of Xiapi: The allied armies led by Cao Cao and Liu Bei defeat Lü Bu; afterward Cao Cao has him executed. By topic Religion * Marcus I succeeds Olympianus as Patriarch of Constantinople (until 211). Births * Lu Kai (or Jingfeng), Chinese official and general (d. 269) * Quan Cong, Chinese general and advisor (d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1889 Births
Events January–March * January 1 ** The total solar eclipse of January 1, 1889 is seen over parts of California and Nevada. ** Paiute spiritual leader Wovoka experiences a vision, leading to the start of the Ghost Dance movement in the Dakotas. * January 4 – An Act to Regulate Appointments in the Marine Hospital Service of the United States is signed by President Grover Cleveland. It establishes a Commissioned Corps of officers, as a predecessor to the modern-day U.S. Public Health Service Commissioned Corps. * January 5 – Preston North End F.C. is declared the winner of the inaugural Football League in England. * January 8 – Herman Hollerith receives a patent for his electric tabulating machine in the United States. * January 15 – The Coca-Cola Company is originally incorporated as the Pemberton Medicine Company in Atlanta, Georgia. * January 22 – Columbia Phonograph is formed in Washington, D.C. * January 30 – Rudolf, Crown Prince of Austria and his ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Westgate-on-Sea
Westgate-on-Sea is a seaside town and civil parish on the north-east coast of Kent, England. It is within the Thanet local government district and borders the larger seaside resort of Margate. Its two sandy beaches have remained a popular tourist attraction since the town's development in the 1860s from a small farming community. The town had a population of 6,996 at the 2011 Census. The town is notable for once being the location of a Royal Naval Air Service seaplane base at St Mildred's Bay, which defended the Thames Estuary coastal towns during World War I. The town is the subject of Sir John Betjeman's poem, "Westgate-on-Sea". Residents have included the 19th-century surgeon Sir Erasmus Wilson and former archbishop of Canterbury William Temple. The artist Sir William Quiller Orchardson painted several of his best-known pictures whilst living in Westgate-on-Sea. The British composer Arnold Cooke attended the town's Streete Preparatory School in the early 20th century, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bodleian Library
The Bodleian Library () is the main research library of the University of Oxford, and is one of the oldest libraries in Europe. It derives its name from its founder, Sir Thomas Bodley. With over 13 million printed items, it is the second-largest library in Britain after the British Library. Under the Legal Deposit Libraries Act 2003, it is one of six legal deposit libraries for works published in the United Kingdom, and under Irish law it is entitled to request a copy of each book published in the Republic of Ireland. Known to Oxford scholars as "Bodley" or "the Bod", it operates principally as a reference library and, in general, documents may not be removed from the reading rooms. In 2000, a number of libraries within the University of Oxford were brought together for administrative purposes under the aegis of what was initially known as Oxford University Library Services (OULS), and since 2010 as the Bodleian Libraries, of which the Bodleian Library is the largest comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Edinburgh
The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established in 1783. , there are around 1,800 Fellows. The Society covers a broader selection of fields than the Royal Society of London, including literature and history. Fellowship includes people from a wide range of disciplines – science & technology, arts, humanities, medicine, social science, business, and public service. History At the start of the 18th century, Edinburgh's intellectual climate fostered many clubs and societies (see Scottish Enlightenment). Though there were several that treated the arts, sciences and medicine, the most prestigious was the Society for the Improvement of Medical Knowledge, commonly referred to as the Medical Society of Edinburgh, co-founded by the mathematician Colin Maclaurin in 1731. Maclaurin was unhappy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elizabeth II
Elizabeth II (Elizabeth Alexandra Mary; 21 April 1926 – 8 September 2022) was Queen of the United Kingdom and other Commonwealth realms from 6 February 1952 until her death in 2022. She was queen regnant of 32 sovereign states during her lifetime, and was head of state of 15 realms at the time of her death. Her reign of 70 years and 214 days was the longest of any British monarch and the longest verified reign of any female monarch in history. Elizabeth was born in Mayfair, London, as the first child of the Duke and Duchess of York (later King George VI and Queen Elizabeth The Queen Mother). Her father acceded to the throne in 1936 upon the abdication of his brother Edward VIII, making the ten-year-old Princess Elizabeth the heir presumptive. She was educated privately at home and began to undertake public duties during the Second World War, serving in the Auxiliary Territorial Service. In November 1947, she married Philip Mountbatten, a former prince ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Babraham Institute
The Babraham Institute is a life sciences research institution and a partner organisation of the University of Cambridge. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme. The Babraham Institute is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. History The institute is located on the historic Babraham Hall Estate (now called the Babraham Research Campus), situated six miles south-east of Cambridge University, near the Gog Magog Hills. It is close to where the ancient Roman Via Devana crossed the prehistoric Ickni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Croonian Lecture
The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single lectureship at both the Royal Society and the Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 .... His wife provided the bequest in 1701 specifying that it was "for the support of a lecture and illustrative experiment for the advancement of natural knowledge on locomotion, or (conditionally) of such other subjects as, in the opinion of the President for the time being, should be most useful in promoting the objects for which the Royal Society was instituted". One lecture was to be delivered by a Fellow of the Royal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lethal Synthesis
Lethal synthesis, or suicide metabolism, is the biosynthesis of a toxin from a precursor which is not itself toxic, such as the synthesis of fluorocitrate from fluoroacetate or the synthesis of methylglyoxal from glycerol. The term was first publicised by Rudolph Peters in his Croonian Lecture of 1951. Lethal Synthesis of Methylglyoxal A 1971 study published by the Harvard Medical School identified methylglyoxal, a form of glycerol, as a product of lethal synthesis in a specific ''E.coli'' mutant. In ''E.coli,'' the synthesis of triose phosphate from glycerol is a reaction regulated by the synthesis rate of glycerol kinase and by feedback inhibition by fructose-1,6-bisphosphate. The study demonstrated that, in ''E.coli'' mutants that had lost both control mechanisms, glycerol kinase no longer reacted to feedback regulation and instead produced the cytotoxic methylglyoxal. A more recent review of research done on methylglyoxal metabolism concluded that the compound's cytotoxic nat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluorocitric Acid
Fluorocitric acid is a Fluorine, fluorinated carboxylic acid derived from citric acid by Substituent, substitution of one hydrogen by a fluorine atom. The appropriate anion is called fluorocitrate. Fluorocitrate is formed in two steps from fluoroacetate. Fluoroacetate is first converted to fluoroacetyl-CoA by acetyl-CoA synthetase in the mitochondria. Then fluoroacetyl-CoA condenses with oxaloacetate to form fluorocitrate. This step is catalyzed by citrate synthase. Flurocitrate is a metabolite of fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle (where fluorocitrate takes place of citrate as the Substrate (biochemistry), substrate). The enzyme is Enzyme inhibitor, inhibited and the cycle stops working. See also * Citric acid * Fluoroacetic acid * Citrate cycle References External links PubChem: Fluorocitrate [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
