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Robin Holliday
Robin Holliday (6 November 1932 – 9 April 2014) was a British molecular biologist. Holliday described a mechanism of DNA-strand exchange that attempted to explain gene-conversion events that occur during meiosis in fungi. That model first proposed in 1964 and is now known as the Holliday Junction. Education and employment Holliday held a B.A. in Natural Sciences and a PhD in genetics from Cambridge University. He was a Fellow of the Royal Society, a Fellow Australian Academy of Science (FAA), a member of the European Molecular Biology Organization, a Foreign Fellow of the Indian National Science Academy, and held the 1987 Lord Cohen Medal for Gerontological research. He was formerly the Head of the Genetics Division, National Institute for Medical Research, (Medical Research Council), Mill Hill, London, UK, and prior to his death was a retired Chief Research Scientist, CSIRO Division of BioMolecular Engineering, Sydney, Australia. Epigenetic research In 1975 he suggested that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holliday Junction
A Holliday junction is a branched nucleic acid structure that contains four double-stranded arms joined. These arms may adopt one of several conformations depending on buffer salt concentrations and the sequence of nucleobases closest to the junction. The structure is named after Robin Holliday, the molecular biologist who proposed its existence in 1964. In biology, Holliday junctions are a key intermediate in many types of genetic recombination, as well as in double-strand break repair. These junctions usually have a symmetrical sequence and are thus mobile, meaning that the four individual arms may slide through the junction in a specific pattern that largely preserves base pairing. Additionally, four-arm junctions similar to Holliday junctions appear in some functional RNA molecules. Immobile Holliday junctions, with asymmetrical sequences that lock the strands in a specific position, were artificially created by scientists to study their structure as a model for natura ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biogerontologist
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journaBIOGERONTOLOGYin 2000. It involves interdisciplinary research on the causes, effects, and mechanisms of biological aging. Biogerontologist Leonard Hayflick has said that the natural average lifespan for a human is around 92 years and, if humans do not invent new approaches to treat aging, they will be stuck with this lifespan. James Vaupel has predicted that life expectancy in industrialized countries will reach 100 for children born after the year 2000. Many surveyed biogerontologists have predicted life expectancies of more than three centuries for people born after the year 2100. Other scientists, more controversially, suggest the possibility of unlimited lifespans for those currently living. For example, Aubrey ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellows Of The Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathematics, engineering science, and medical science". Fellowship of the Society, the oldest known scientific academy in continuous existence, is a significant honour. It has been awarded to many eminent scientists throughout history, including Isaac Newton (1672), Michael Faraday (1824), Charles Darwin (1839), Ernest Rutherford (1903), Srinivasa Ramanujan (1918), Albert Einstein (1921), Paul Dirac (1930), Winston Churchill (1941), Subrahmanyan Chandrasekhar (1944), Dorothy Hodgkin (1947), Alan Turing (1951), Lise Meitner (1955) and Francis Crick (1959). More recently, fellowship has been awarded to Stephen Hawking (1974), David Attenborough (1983), Tim Hunt (1991), Elizabeth Blackburn (1992), Tim Berners-Lee (2001), Venki Ramak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellows Of The Australian Academy Of Science
The Fellowship of the Australian Academy of Science is made up of about 500 Australian scientists. Scientists judged by their peers to have made an exceptional contribution to knowledge in their field may be elected to Fellowship of the Academy. Fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...s are often denoted using the post-nominal FAA (Fellow of the Australian Academy of Science). A small number of distinguished foreign scientists with substantial connections to Australian science are elected as Corresponding Members. Fellows are appointed for life; this table also contains deceased fellows. Fellows Corresponding Members References *Australian Academy of ScienceFellowship list External links *http://www.asap.unimelb.edu.au/asap_inf.htm – Australian Scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Australian Geneticists
Australian(s) may refer to: Australia * Australia, a country * Australians, citizens of the Commonwealth of Australia ** European Australians ** Anglo-Celtic Australians, Australians descended principally from British colonists ** Aboriginal Australians, indigenous peoples of Australia as identified and defined within Australian law * Australia (continent) ** Indigenous Australians * Australian English, the dialect of the English language spoken in Australia * Australian Aboriginal languages * ''The Australian'', a newspaper * Australiana, things of Australian origins Other uses * Australian (horse), a racehorse * Australian, British Columbia, an unincorporated community in Canada See also * The Australian (other) * Australia (other) * * * Austrian (other) Austrian may refer to: * Austrians, someone from Austria or of Austrian descent ** Someone who is considered an Austrian citizen, see Austrian nationality law * Austrian German dialect * Somet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2014 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1932 Births
Year 193 ( CXCIII) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Sosius and Ericius (or, less frequently, year 946 ''Ab urbe condita''). The denomination 193 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * January 1 – Year of the Five Emperors: The Roman Senate chooses Publius Helvius Pertinax, against his will, to succeed the late Commodus as Emperor. Pertinax is forced to reorganize the handling of finances, which were wrecked under Commodus, to reestablish discipline in the Roman army, and to suspend the food programs established by Trajan, provoking the ire of the Praetorian Guard. * March 28 – Pertinax is assassinated by members of the Praetorian Guard, who storm the imperial palace. The Empire is auctioned of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Hamster Ovary Cell
Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins. They have found wide use in studies of genetics, toxicity screening, nutrition and gene expression, particularly to express recombinant proteins. CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics. History Chinese hamsters had been used in research since 1919, where they were used in place of mice for typing pneumococci. They were subsequently found to be excellent vectors for transmission of kala-azar (visceral leishmaniasis), facilitating ''Leishmania'' research. In 1948, the Chinese hamster was first used in the United States for breeding in research laboratories. In 1957, Theodore T. Puck obtained a female Chinese hamster from Dr. George Yerganian's laboratory at the Boston Cancer Research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suresh Rattan
Suresh Rattan (full name: ''Suresh Inder Singh Rattan''; born in 1955 in Amritsar, India) is a biogerontologist – a researcher in the field of biology of ageing, biogerontology. In addition to his professional research work on the biology of ageing, he is also very much interested and involved in the public communication of science and he likes to undertake explorations in the Indian classical music and semi-classical music by playing Tabla – the North Indian drums, as evident from music CDs "State of the Art: Small Town People" by Harry Jokumsen and other artists (2008), and "The Fall and the Rise of a Woman" by Pearl (2014) in which he plays Tabla under his artistic name Shashi Maharaj. Academic background Suresh Rattan has been heading, since its inception in 1984, the Laboratory of Cellular Ageing at the Department of Molecular Biology and Genetics at the Aarhus University in Denmark, where he has become Emeritus since 2020. He was introduced to the field of ageing by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetic
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene express ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CSIRO
The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is an Australian Government agency responsible for scientific research. CSIRO works with leading organisations around the world. From its headquarters in Canberra, CSIRO maintains more than 50 sites across Australia and in France, Chile and the United States, employing about 5,500 people. Federally funded scientific research began in Australia years ago. The Advisory Council of Science and Industry was established in 1916 but was hampered by insufficient available finance. In 1926 the research effort was reinvigorated by establishment of the Council for Scientific and Industrial Research (CSIR), which strengthened national science leadership and increased research funding. CSIR grew rapidly and achieved significant early successes. In 1949, further legislated changes included renaming the organisation as CSIRO. Notable developments by CSIRO have included the invention of atomic absorption spectroscopy, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
