Robert T. Sauer
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Robert T. Sauer
Robert Thomas Sauer (born 13 July 1948) is an American biochemist who is the Salvador E. Luria Professor of Biology at the Massachusetts Institute of Technology. Early life and education Bob Sauer was born in Cornwall, New York, in the Hudson Valley area of New York. He attended Amherst College in Massachusetts as an undergraduate and earned his bachelor's degree in biophysics in 1972. He received his PhD in Biochemistry and Molecular Biology from Harvard University in 1979. Academic career Sauer joined the faculty at the Massachusetts Institute of Technology in 1978, a year before he completed his PhD. He has remained at MIT for his entire academic career, becoming a full professor in 1987 and the Edwin C. Whitehead Professor in 1991. Sauer assumed his current appointment as the Salvador E. Luria Professor of Biology in 1999. He has held a number of service roles at MIT and spent five years, from 1999 to 2004, as the head of the biology department. He was the president of the ...
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Cornwall, New York
Cornwall is a town in Orange County, New York, United States, approximately north of New York City on the western shore of the Hudson River. As of the 2020 census, the population was at 12,884. Cornwall has become a bedroom community for area towns and cities including New York City. Commuter rail service to North Jersey and New York City is available via the Salisbury Mills–Cornwall train station, operated by NJ Transit on behalf of Metro-North Railroad. The town is located less than an hour from the George Washington Bridge with access to major commuter routes such as the New York State Thruway and the Palisades Parkway. Cornwall's Main Street includes gift shops, taverns, restaurants, coffeehouses, yoga studios and boutiques. Government offices, churches, parks, the riverfront, and St. Luke's Cornwall Hospital, a part of the Montefiore Health System, are situated within walking distance of downtown. The town is a designated Tree City. Cornwall was featured as "The Best ...
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Hans Neurath
Hans Neurath (October 29, 1909 – April 2002) was a biochemist, a leader in protein chemistry, and the founding chairman of the Department of Biochemistry at the University of Washington in Seattle. He was born in Vienna, Austria and received his doctorate in 1933 from the University of Vienna. He then studied in London and at the University of Minnesota. In 1938, he was appointed professor at Duke University, where he established a research program on the physical chemistry of proteins. Neurath was a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and a foreign member of the Max Planck Society of Germany. Scientific research Neurath had wide-ranging interests in the physical chemistry of proteins. He published seminal papers on protein structure and denaturation and debunked early models of protein structures, notably those of William Astbury. His research focused mainly on the proteases, (proteins that act as enzymes cleaving other ...
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Fellows Of The American Academy Of Arts And Sciences
Fellows may refer to Fellow, in plural form. Fellows or Fellowes may also refer to: Places *Fellows, California, USA *Fellows, Wisconsin, ghost town, USA Other uses *Fellows Auctioneers, established in 1876. *Fellowes, Inc., manufacturer of workspace products *Fellows, a partner in the firm of English canal carriers, Fellows Morton & Clayton *Fellows (surname) See also *North Fellows Historic District, listed on the National Register of Historic Places in Wapello County, Iowa *Justice Fellows (other) Justice Fellows may refer to: * Grant Fellows (1865–1929), associate justice of the Michigan Supreme Court * Raymond Fellows (1885–1957), associate justice of the Maine Supreme Judicial Court {{disambiguation, tndis ...
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Members Of The United States National Academy Of Sciences
Member may refer to: * Military jury, referred to as "Members" in military jargon * Element (mathematics), an object that belongs to a mathematical set * In object-oriented programming, a member of a class ** Field (computer science), entries in a database ** Member variable, a variable that is associated with a specific object * Limb (anatomy), an appendage of the human or animal body ** Euphemism for penis * Structural component of a truss, connected by nodes * User (computing), a person making use of a computing service, especially on the Internet * Member (geology), a component of a geological formation * Member of parliament * The Members, a British punk rock band * Meronymy, a semantic relationship in linguistics * Church membership, belonging to a local Christian congregation, a Christian denomination and the universal Church * Member, a participant in a club or learned society A learned society (; also learned academy, scholarly society, or academic association) is an ...
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Amherst College Alumni
Amherst may refer to: People * Amherst (surname), including a list of people with the name * Earl Amherst of Arracan in the East Indies, a title in the British Peerage; formerly ''Baron Amherst'' * Baron Amherst of Hackney of the City of London, a title in the British Peerage Places Australia *Amherst, Victoria Burma * Kyaikkami, Myanmar, formerly known as Amherst Canada * Amherst Cove, Newfoundland and Labrador * Middle Amherst Cove, Newfoundland and Labrador *Upper Amherst Cove, Newfoundland and Labrador * Amherst, Nova Scotia *Amherst Head, Nova Scotia * Amherst Internment Camp, Nova Scotia (1915-1919) *Amherst Point, Nova Scotia * Amherst Shore, Nova Scotia * East Amherst, Nova Scotia *West Amherst, Nova Scotia *Amherst Island, Ontario *Amherst Pointe, Ontario *Amherstburg, Ontario *Amherstview, Ontario *Amherst, Quebec * Saint-Rémi-d'Amherst, Quebec *Amherst Island (Nunavut) United States *Amherst, Colorado *Amherst, Maine * Amherst, Massachusetts *Amherst Center, Massa ...
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Harvard University Alumni
The list of Harvard University people includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see notable non-graduate alumni of Harvard. For a list of Harvard's presidents, see President of Harvard University. Eight President of the United States, Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ...
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Massachusetts Institute Of Technology School Of Science Faculty
Massachusetts (Massachusett language, Massachusett: ''Muhsachuweesut [Massachusett writing systems, məhswatʃəwiːsət],'' English: , ), officially the Commonwealth of Massachusetts, is the most populous U.S. state, state in the New England region of the Northeastern United States. It borders on the Atlantic Ocean and Gulf of Maine to the east, Connecticut and Rhode Island to the south, New Hampshire and Vermont to the north, and New York (state), New York to the west. The state's capital and List of municipalities in Massachusetts, most populous city, as well as its cultural and financial center, is Boston. Massachusetts is also home to the urban area, urban core of Greater Boston, the largest metropolitan area in New England and a region profoundly influential upon American History of the United States, history, academia, and the Economy of the United States, research economy. Originally dependent on agriculture, fishing, and trade. Massachusetts was transformed into a manuf ...
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American Biochemists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ...
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Protein Degradation
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing the accumulation of unwanted or misfolded proteins in cells. Consequently, abnormality in the regulation of proteolysis can cause disease. Proteolysis can also be used as an analytical tool for studying proteins in the laboratory, and it may also be used in industry, for example in food process ...
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DNA-binding Protein
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for DNA#Base pairing, single- or double-stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However, there are some known minor groove DNA-binding ligands such as netropsin, distamycin, Hoechst 33258, pentamidine, DAPI and others. Examples DNA-binding proteins include transcription factors which Gene modulation, modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging and transcription in the cell nucleus. DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid. There are also more unusual examples such as TAL effector, transcription activa ...
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Intermolecular Interaction
An intermolecular force (IMF) (or secondary force) is the force that mediates interaction between molecules, including the electromagnetic forces of attraction or repulsion which act between atoms and other types of neighbouring particles, e.g. atoms or ions. Intermolecular forces are weak relative to intramolecular forces – the forces which hold a molecule together. For example, the covalent bond, involving sharing electron pairs between atoms, is much stronger than the forces present between neighboring molecules. Both sets of forces are essential parts of force fields frequently used in molecular mechanics. The investigation of intermolecular forces starts from macroscopic observations which indicate the existence and action of forces at a molecular level. These observations include non-ideal-gas thermodynamic behavior reflected by virial coefficients, vapor pressure, viscosity, superficial tension, and absorption data. The first reference to the nature of microscopic for ...
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Protein Folding
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA to a linear chain of amino acids. At this stage the polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding of many proteins begins even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), ...
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