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Robert F. Furchgott
Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems. Early life and education Furchgott was born in Charleston, South Carolina, to Arthur Furchgott (December 1884 – January 1971), a department store owner, and Pena (Sorentrue) Furchgott. He graduated with from the University of North Carolina at Chapel Hill in 1937 with a degree in chemistry and went on to earn a Ph.D in biochemistry at Northwestern University in 1940. Career Furchgott was faculty member and professor of pharmacology at Cornell University Medical College from 1940 to 1949, at Washington University School of Medicine from 1949 to 1956, at SUNY Brooklyn from 1956 to 1989, and at the University of Miami from 1989 through the end of his career. In 1978, Furchgott discovered a substance in endothelial cells that relaxes blood vessels, calling it endotheli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charleston, South Carolina
Charleston is the largest city in the U.S. state of South Carolina, the county seat of Charleston County, and the principal city in the Charleston–North Charleston metropolitan area. The city lies just south of the geographical midpoint of South Carolina's coastline on Charleston Harbor, an inlet of the Atlantic Ocean formed by the confluence of the Ashley, Cooper, and Wando rivers. Charleston had a population of 150,277 at the 2020 census. The 2020 population of the Charleston metropolitan area, comprising Berkeley, Charleston, and Dorchester counties, was 799,636 residents, the third-largest in the state and the 74th-largest metropolitan statistical area in the United States. Charleston was founded in 1670 as Charles Town, honoring King CharlesII, at Albemarle Point on the west bank of the Ashley River (now Charles Towne Landing) but relocated in 1680 to its present site, which became the fifth-largest city in North America within ten years. It remained unincorpor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weill Cornell Medicine
The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with NewYork-Presbyterian Hospital, Weill Cornell Medical Center, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, and Rockefeller University, all of which are located nearby on York Avenue. Weill Cornell's clinical affiliates rank highly, with the NewYork-Presbyterian Hospital ranked #1 in the region and #4 in the nation, the Hospital for Special Surgery ranked #1 in the nation for orthopedics and the Memorial Sloan Kettering Center #2 for cancer. Memorial Sloan Kettering Cancer Center and Rockefeller University joined Weill Cornell to establish the Tri-Institutional MD–PhD Program in 1991. In 2001, the school opened a campus in Qatar. Weill Cornell has also been affiliated with Houston Methodist Hospital since 2004. On Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gairdner Foundation International Award
The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2020, 95 Nobel Prizes have been awarded to prior Gairdner recipients. Canada Gairdner International Awards are given annually in the amount of $100,000 (each) payable in Canadian funds and can be awarded to residents of any country in the world. A joint award may be given for the same discovery or contribution to medical science, but in that case each awardee receives a full prize. Past winners *1959 Alfred Blalock, , Harry M. Rose, William D.M. Paton, Eleanor Zaimis, Wilfred G. Bigelow *1960 Joshua Harold Burn, John H. Gibbon Jr., William F. Hamilton, John McMichael, Karl Meyer, Arnold Rice Rich *1961 Russell Brock, Alan C. Burton, Alexander B. Gutman, Jonas H. Kellgren ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viagra
Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by mouth or by injection into a vein. Onset is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. Caution is advised in those with cardiovascular disease. Rare but serious side effects include a prolonged erection (priapism) that can lead to damage to the penis, vision problems, and hearing loss. Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. Sildenafil should not be taken within four hours of taking an alpha blocker. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angina Pectoris
Angina, also known as angina pectoris, is chest pain or pressure, usually caused by insufficient blood flow to the heart muscle (myocardium). It is most commonly a symptom of coronary artery disease. Angina is typically the result of obstruction or spasm of the arteries that supply blood to the heart muscle. The main mechanism of coronary artery obstruction is atherosclerosis as part of coronary artery disease. Other causes of angina include abnormal heart rhythms, heart failure and, less commonly, anemia. The term derives from the Latin ''angere'' ("to strangle") and ''pectus'' ("chest"), and can therefore be translated as "a strangling feeling in the chest". There is a weak relationship between severity of angina and degree of oxygen deprivation in the heart muscle, however, the severity of angina does not always match the degree of oxygen deprivation to the heart or the risk of a myocardial infarction (heart attack). Some people may experience severe pain even though the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitroglycerin
Nitroglycerin (NG), (alternative spelling of nitroglycerine) also known as trinitroglycerin (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a dense, colorless, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester. Chemically, the substance is an organic nitrate compound rather than a nitro compound, but the traditional name is retained. Invented in 1847 by Ascanio Sobrero, nitroglycerin has been used ever since as an active ingredient in the manufacture of explosives, namely dynamite, and as such it is employed in the construction, demolition, and mining industries. Since the 1880s, it has been used by militaries as an active ingredient and gelatinizer for nitrocellulose in some solid propellants such as cordite and ballistite. It is a major component in double-based smokeless propellants used by reloaders. Combined with nitrocellulose, hund ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The American Medical Association
''The Journal of the American Medical Association'' (''JAMA'') is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biomedicine. The journal was established in 1883 with Nathan Smith Davis as the founding editor. Kirsten Bibbins-Domingo of the University of California San Francisco became the journal editor-in-chief on July 1, 2022, succeeding Howard Bauchner of Boston University. History The journal was established in 1883 by the American Medical Association and superseded the ''Transactions of the American Medical Association''. ''Councilor's Bulletin'' was renamed the ''Bulletin of the American Medical Association'', which later was absorbed by the ''Journal of the American Medical Association''. In 1960, the journal obtained its current title, ''JAMA: The Journal of the American Medical Association''. The journal is commonly referred to as ''JAMA''. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquired ''The Lancet'' from Hodder & Stoughton in 1991. Impact According to the ''Journal Citation Reports'', the journal has a 202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferid Murad
Ferid Murad (born September 14, 1936) is an American physician and pharmacologist, and a co-winner of the 1998 Nobel Prize in Physiology or Medicine. Early life Murad was born in Whiting, Indiana. His parents were Henrietta Josephine Bowman of Alton, Illinois and Xhabir Murat Ejupi, an Albanian immigrant from Gostivar in present-day North Macedonia. who subsequently changed his name to John Murad after being processed at Ellis Island in 1913. His mother was from a Baptist family and ran away from home in 1935, aged 17, to marry his father, who was 39 and Muslim. Murad is the oldest of three boys; his brothers are John Abderhaman and Turhon Allen. Murad and his brothers were raised as Catholics. He was later baptized an Episcopalian while in college. The family owned a small restaurant while Murad was growing up, and he spent his youth working at the family business. In the eighth grade, he was asked to write an essay of his top three career choices, which he indicated as ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Ignarro
Louis J. Ignarro (born May 31, 1941) is an American pharmacologist. For demonstrating the signaling properties of nitric oxide, he was co-recipient of the 1998 Nobel Prize in Physiology or Medicine with Robert F. Furchgott and Ferid Murad. Currently, he is professor emeritus of pharmacology at the UCLA School of Medicine's department of molecular and medical pharmacology in Los Angeles, which he joined in 1985. Before relocating to California, he was a professor of pharmacology at Tulane University School of Medicine, New Orleans, for 12 years. Ignarro has also previously worked as a staff scientist, research department, for the pharmaceutical division of Novartis, CIBA-GEIGY Corporation in New York. Ignarro has published numerous research articles. He received the Basic Research Prize of the American Heart Association in 1998. This was in recognition of his outstanding contributions to the advancement of cardiovascular science. That same year, he was inducted into the Nation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitric Oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its chemical formula In chemistry, a chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, ... (•N=O or •NO). Nitric oxide is also a heteronuclear diatomic molecule, a class of molecules whose study spawned early modern molecular orbital theory, theories of chemical bonding. An important Reaction intermediate, intermediate in chemical industry, industrial chemistry, nitric oxide forms in combustion systems and can be generated by lightning in thunderstorms. In mammals, including humans, nitric oxide is a signaling molecule in many physiological and pathological pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endothelium-derived Relaxing Factor
Endothelium-derived relaxing factor (EDRF) is a name for a Chemical substance, substance that Robert F. Furchgott discovered had the eponymous properties. Today, it is firmly established this substance is nitric oxide (NO). Endothelium produces NO which then diffuses to the vascular smooth muscle tissue, although there seems to be evidence that vasodilation may also be of neuronal origin, rather than endothelial. NO is produced by the enzyme nitric oxide synthase and it relaxes Smooth muscle, smooth muscle tissue by promoting the synthesis of Cyclic guanosine monophosphate, cGMP. Furchgott was a co-recipient of the 1998 Nobel Prize in Physiology or Medicine, Nobel Prize in Medicine with his colleagues Louis J. Ignarro and Ferid Murad. Shortly after his death in May 2009, Furchgott's website at SUNY Downstate Medical Center continued to state that his group was "investigating whether the endothelium-derived relaxing factor (EDRF) is simply nitric oxide or a mixture of substances". ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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