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Reiji Okazaki
was a pioneer Japanese molecular biologist, known for his research on DNA replication and especially for describing the role of Okazaki fragments along with his wife Tsuneko. Okazaki was born in Hiroshima, Japan. He graduated in 1953 from Nagoya University, and worked as a professor there after 1963. He died of leukemia in 1975 at the age of 44 while traveling to the United States; he had been heavily irradiated in Hiroshima when the first atomic bomb was dropped. Okazaki Fragments In 1968, Reiji and Tsuneko Okazaki discovered the way in which the lagging strand of DNA is replicated via fragments, now called Okazaki fragments. Their experiments used ''E. coli''. After introducing 3T-thymidine for only ten seconds to ''E. coli'' during DNA replication, they placed the sample in a test tube of alkaline sucrose. The larger, heavier DNA flowed to the bottom of the test tube, while the smaller, lighter DNA did not. When samples were taken from the bottom of the test tube, it was f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Kornberg
Arthur Kornberg (March 3, 1918 – October 26, 2007) was an American biochemist who won the Nobel Prize in Physiology or Medicine 1959 for the discovery of "the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid" together with Spanish biochemist and physician Severo Ochoa of New York University. He was also awarded the Paul-Lewis Award in Enzyme Chemistry from the American Chemical Society in 1951, an L.H.D. degree from Yeshiva University in 1962, and the National Medal of Science in 1979. In 1991, Kornberg received the Golden Plate Award of the American Academy of Achievement and the Gairdner Foundation Award in 1995. His primary research interests were in biochemistry, especially enzyme chemistry, deoxyribonucleic acid synthesis (DNA replication) and studying the nucleic acids which control heredity in animals, plants, bacteria and viruses. Early life and education Born in New York City, Kornberg was the son of Jewish parents Joseph and Lena ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Polymerase I
DNA polymerase I (or Pol I) is an enzyme that participates in the process of prokaryotic DNA replication. Discovered by Arthur Kornberg in 1956, it was the first known DNA polymerase (and the first known of any kind of polymerase). It was initially characterized in '' E. coli'' and is ubiquitous in prokaryotes. In ''E. coli'' and many other bacteria, the gene that encodes Pol I is known as ''polA''. The ''E. coli'' Pol I enzyme is composed of 928 amino acids, and is an example of a processive enzyme — it can sequentially catalyze multiple polymerisation steps without releasing the single-stranded template. The physiological function of Pol I is mainly to support repair of damaged DNA, but it also contributes to connecting Okazaki fragments by deleting RNA primers and replacing the ribonucleotides with DNA. Discovery In 1956, Arthur Kornberg and colleagues discovered Pol I by using ''Escherichia coli'' (''E. coli'') extracts to develop a DNA synthesis assay. The scientist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hibakusha
''Hibakusha'' ( or ; ja, 被爆者 or ; "person affected by a bomb" or "person affected by exposure o radioactivity) is a word of Japanese origin generally designating the people affected by the atomic bombings of Hiroshima and Nagasaki at the end of World War II. Definition The word ''hibakusha'' is Japanese, originally written in kanji. While the term Hibakusha (''hi'' "affected" + ''baku'' "bomb" + ''sha'' "person") has been used before in Japanese to designate any victim of bombs, its worldwide democratisation led to a definition concerning the survivors of the atomic bombs dropped in Japan by the United States Army Air Forces on the 6 and 9 August 1945. Anti-nuclear movements and associations, among others of ''hibakusha'', spread the term to designate any direct victim of nuclear disaster, including the ones of the nuclear plant in Fukushima. They therefore prefer the writing (substituting ''baku'' with the homophonous "exposition") or "person affected by the ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Hiroshima
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Molecular Biologists
Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspora, Japanese emigrants and their descendants around the world * Japanese citizens, nationals of Japan under Japanese nationality law ** Foreign-born Japanese, naturalized citizens of Japan * Japanese writing system, consisting of kanji and kana * Japanese cuisine, the food and food culture of Japan See also * List of Japanese people * * Japonica (other) * Japonicum * Japonicus * Japanese studies Japanese studies ( Japanese: ) or Japan studies (sometimes Japanology in Europe), is a sub-field of area studies or East Asian studies involved in social sciences and humanities research on Japan. It incorporates fields such as the study of Japan ... {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Biochemists
Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspora, Japanese emigrants and their descendants around the world * Japanese citizens, nationals of Japan under Japanese nationality law ** Foreign-born Japanese, naturalized citizens of Japan * Japanese writing system, consisting of kanji and kana * Japanese cuisine, the food and food culture of Japan See also * List of Japanese people * * Japonica (other) * Japonicum * Japonicus * Japanese studies Japanese studies (Japanese: ) or Japan studies (sometimes Japanology in Europe), is a sub-field of area studies or East Asian studies involved in social sciences and humanities research on Japan. It incorporates fields such as the study of Japanese ... {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1975 Deaths
It was also declared the ''International Women's Year'' by the United Nations and the European Architectural Heritage Year by the Council of Europe. Events January * January 1 - Watergate scandal (United States): John N. Mitchell, H. R. Haldeman and John Ehrlichman are found guilty of the Watergate cover-up. * January 2 ** The Federal Rules of Evidence are approved by the United States Congress. ** Bangladesh revolutionary leader Siraj Sikder is killed by police while in custody. ** A bomb blast at Samastipur, Bihar, India, fatally wounds Lalit Narayan Mishra, Minister of Railways. * January 5 – Tasman Bridge disaster: The Tasman Bridge in Hobart, Tasmania, Australia, is struck by the bulk ore carrier , killing 12 people. * January 7 – OPEC agrees to raise crude oil prices by 10%. * January 10–February 9 – The flight of ''Soyuz 17'' with the crew of Georgy Grechko and Aleksei Gubarev aboard the ''Salyut 4'' space station. * January 15 – Alvor Agreement: Portuga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1930 Births
Year 193 ( CXCIII) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Sosius and Ericius (or, less frequently, year 946 '' Ab urbe condita''). The denomination 193 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * January 1 – Year of the Five Emperors: The Roman Senate chooses Publius Helvius Pertinax, against his will, to succeed the late Commodus as Emperor. Pertinax is forced to reorganize the handling of finances, which were wrecked under Commodus, to reestablish discipline in the Roman army, and to suspend the food programs established by Trajan, provoking the ire of the Praetorian Guard. * March 28 – Pertinax is assassinated by members of the Praetorian Guard, who storm the imperial palace. The Empire is auctioned o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Ligase
DNA ligase is a specific type of enzyme, a ligase, () that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role in repairing single-strand breaks in duplex DNA in living organisms, but some forms (such as DNA ligase IV) may specifically repair double-strand breaks (i.e. a break in both complementary strands of DNA). Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA. DNA ligase is used in both DNA repair and DNA replication (see '' Mammalian ligases''). In addition, DNA ligase has extensive use in molecular biology laboratories for recombinant DNA experiments (see '' Research applications''). Purified DNA ligase is used in gene cloning to join DNA molecules together to form recombinant DNA. Enzymatic mechanism The mechanism of DNA ligase is to form two covalent phos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atomic Bombings Of Hiroshima And Nagasaki
The United States detonated two atomic bombs over the Japanese cities of Hiroshima and Nagasaki on 6 and 9 August 1945, respectively. The two bombings killed between 129,000 and 226,000 people, most of whom were civilians, and remain the only use of nuclear weapons in armed conflict so far. In the final year of World War II, the Allies prepared for a costly invasion of the Japanese mainland. This undertaking was preceded by a conventional and firebombing campaign that devastated 64 Japanese cities. The war in the European theatre concluded when Germany surrendered on 8 May 1945, and the Allies turned their full attention to the Pacific War. By July 1945, the Allies' Manhattan Project had produced two types of atomic bombs: "Fat Man", a plutonium implosion-type nuclear weapon; and "Little Boy", an enriched uranium gun-type fission weapon. The 509th Composite Group of the United States Army Air Forces was trained and equipped with the specialized Silverplate version of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biologist
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Little Boy
"Little Boy" was the type of atomic bomb dropped on the Japanese city of Hiroshima on 6 August 1945 during World War II, making it the first nuclear weapon used in warfare. The bomb was dropped by the Boeing B-29 Superfortress ''Enola Gay'' piloted by Colonel Paul W. Tibbets, Jr., commander of the 509th Composite Group of the United States Army Air Forces and Captain Robert A. Lewis. It exploded with an energy of approximately and caused widespread death and destruction throughout the city. The Hiroshima bombing was the second man-made nuclear explosion in history, after the Trinity nuclear test. Little Boy was developed by Lieutenant Commander Francis Birch (geophysicist), Francis Birch's group at the Manhattan Project's Los Alamos Laboratory during World War II, a reworking of their unsuccessful Thin Man (nuclear bomb), Thin Man nuclear bomb. Like Thin Man, it was a gun-type fission weapon, but it derived its explosive power from the nuclear fission of uranium-235, where ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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