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Regina Barzilay
Regina Barzilay (born 1970) is an Israeli-American computer scientist. She is a professor at the Massachusetts Institute of Technology and a faculty lead for artificial intelligence at the MIT Jameel Clinic. Her research interests are in natural language processing and applications of deep learning to chemistry and oncology. Education Barzilay was born in Chișinău, Moldova and emigrated to Israel with her parents at the age of 20. She received bachelor and masters degrees from Ben-Gurion University of the Negev in 1993 and 1998, respectively. She obtained a PhD in computer science from Columbia University in 2003 for research supervised by Kathleen McKeown. Career and research After her PhD, she spent a year as a postdoctoral researcher at Cornell University. She was appointed as Delta Electronics Professor of Electrical Engineering and Computer Science at MIT in 2016. She was diagnosed with breast cancer in 2014, which prompted her to conduct research in oncology. Barzilay w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chișinău
Chișinău ( , , ), also known as Kishinev (russian: Кишинёв, r=Kishinjóv ), is the Capital city, capital and largest city of the Republic of Moldova. The city is Moldova's main industrial and commercial center, and is located in the middle of the country, on the river Bîc River, Bâc, a tributary of the Dniester. According to the results of the 2014 Moldovan census, 2014 census, the city proper had a population of 532,513, while the population of the Municipality of Chișinău (which includes the city itself and other nearby communities) was 700,000. Chișinău is the most economically prosperous locality in Moldova and its largest transportation hub. Nearly a third of Moldova's population lives in the metro area. Etymology The origin of the city's name is unclear. A theory suggests that the name may come from the archaism, archaic Romanian word ''chișla'' (meaning "spring", "source of water") and ''nouă'' ("new"), because it was built around a small spring, at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MIT Jameel Clinic
The MIT Abdul Latif Jameel Clinic for Machine Learning in Health (commonly, MIT Jameel Clinic; previously, J-Clinic) is a research center at the Massachusetts Institute of Technology (MIT) in the field of artificial intelligence (AI) and health sciences, including disease detection, drug discovery, and the development of medical devices. The MIT Jameel Clinic also supports the commercialization of solutions through grant funding, and has partnered with pharmaceutical companies, like Takeda and Sanofi, to forge collaborations between research and development functions and MIT researchers. Co-founded in 2018 by MIT and Community Jameel, the MIT Jameel Clinic is housed in the MIT Schwarzman College of Computing. The mission of the Jameel Clinic is to "revolutionize the prevention, detection, and treatment of disease", and it describes itself as "the epicenter of AI and healthcare at MIT". History On September 17, 2018, the MIT Jameel Clinic was co-founded by MIT and Community Jamee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antimicrobial Resistance
Antimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials. All classes of microbes can evolve resistance. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. Protozoa evolve antiprotozoal resistance, and bacteria evolve antibiotic resistance. Those bacteria that are considered extensively drug resistant (XDR) or totally drug-resistant (TDR) are sometimes called "superbugs".A.-P. Magiorakos, A. Srinivasan, R. B. Carey, Y. Carmeli, M. E. Falagas, C. G. Giske, S. Harbarth, J. F. Hinndler ''et al''Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria... Clinical Microbiology and Infection, Vol 8, Iss. 3 first published 27 July 2011 ia Wiley Online Library Retrieved 28 August 2020 Although antimicrobial resistance is a naturally-occurring process, it is often the result of improper usage of the drugs and management of the infections. Antibiotic resistance is a major subset o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Halicin
Halicin (SU-3327) is a chemical compound that acts as an inhibitor of the enzyme c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes, but development was discontinued for this application due to poor results in testing. Naming Researchers named the molecule after the fictional artificial intelligence system from ''2001: A Space Odyssey'' because of how AI predictive computer models were used to identify the probability it would work as an antibiotic. Antibiotic ability Halicin was identified by artificial intelligence researchers at the MIT Jameel Clinic in 2019 using an ''in silico'' deep learning approach, as a likely broad-spectrum antibiotic. This likelihood was verified by ''in vitro'' cell culture testing, followed by ''in vivo'' tests in mice. It showed activity against drug-resistant strains of ''Clostridioides difficile (bacteria), Clostridiodes difficile'', ''Acinetobacter baumannii'', and ''Mycobacterium tuberculosis'', with an u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Collins (bioengineer)
James J. Collins (born June 26, 1965) is an American bioengineer, and the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT. He is one of the founders of the emerging field of synthetic biology, and has made multiple synthetic biology breakthroughs in biotechnology and biomedicine, including paper-based diagnostics for Zika & Ebola and programmable cells that serve as living diagnostics and living therapeutics to detect-and-treat infections, rare genetic metabolic disorders, and inflammatory bowel disease. Collins is also a pioneering researcher in systems biology, having made fundamental discoveries regarding the actions of antibiotics and the emergence of antibiotic resistance. Collins was elected a member of the National Academy of Engineering in 2011 for contributions to synthetic biology and engineered gene networks. Biography Collins received a bachelor's degree in physics (summa cum laude; class valedictorian) from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Device
A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assurance before regulating governments allow marketing of the device in their country. As a general rule, as the associated risk of the device increases the amount of testing required to establish safety and efficacy also increases. Further, as associated risk increases the potential benefit to the patient must also increase. Discovery of what would be considered a medical device by modern standards dates as far back as c. 7000 BC in Baluchistan where Neolithic dentists used flint-tipped drills and bowstrings. Study of archeology and Roman medical literature also indicate that many types of medical devices were in widespread use during the time of ancient Rome. In the United States it wasn't until the Federal Food, Drug, and Cosmetic Act (F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Modern drug discovery involves the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach and make contributions in all fields of knowledge—from the classics to the sciences, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's founding principle, a popular 1868 quotation from founder Ezra Cornell: "I would found an institution where any person can find instruction in any study." Cornell is ranked among the top global universities. The university is organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its specific admission standards and academic programs in near autonomy. The university also administers three satellite campuses, two in New York City and one in Education City, Qatar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Researcher
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Israel
Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated on the southeastern shore of the Mediterranean Sea and the northern shore of the Red Sea, and shares borders with Lebanon to the north, Syria to the northeast, Jordan to the east, and Egypt to the southwest. Israel also is bordered by the Palestinian territories of the West Bank and the Gaza Strip to the east and west, respectively. Tel Aviv is the economic and technological center of the country, while its seat of government is in its proclaimed capital of Jerusalem, although Israeli sovereignty over East Jerusalem is unrecognized internationally. The land held by present-day Israel witnessed some of the earliest human occupations outside Africa and was among the earliest known sites of agriculture. It was inhabited by the Canaanites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
