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Ralph Raphael
Ralph Alexander Raphael (1 January 1921 – 27 April 1998) was a British organic chemist, well known for his use of acteylene derivatives in the synthesis of natural products with biological activity. Early life and education Ralph Raphael was born in Croydon, London on New Year's Day 1921, the son of master tailor Jacob ("Jack") Raphael (1889-1978) and his wife, Lily (née Woolf; 1892-1956). He attended secondary school at Wesley College, Dublin and then Tottenham County School, where a chemistry master, Edgar Ware, introduced him to the subject that would become Raphael's lifetime passion. In 1939 he won scholarships to study at Imperial College, graduating BSc with a first-class degree in 1941 and winning the Hofmann Prize for practical chemistry. During the Second World War both the undergraduate and PhD courses at Imperial College were of two year's duration and Raphael completed the latter in 1943. His doctoral work, aimed at the synthesis of vitamin A, was published ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Croydon
Croydon is a large town in south London, England, south of Charing Cross. Part of the London Borough of Croydon, a local government district of Greater London. It is one of the largest commercial districts in Greater London, with an extensive shopping district and night-time economy. The entire town had a population of 192,064 as of 2011, whilst the wider borough had a population of 384,837. Historically an ancient parish in the Wallington hundred of Surrey, at the time of the Norman conquest of England Croydon had a church, a mill, and around 365 inhabitants, as recorded in the Domesday Book of 1086. Croydon expanded in the Middle Ages as a market town and a centre for charcoal production, leather tanning and brewing. The Surrey Iron Railway from Croydon to Wandsworth opened in 1803 and was an early public railway. Later 19th century railway building facilitated Croydon's growth as a commuter town for London. By the early 20th century, Croydon was an important industria ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Sondheimer
Franz Sondheimer FRS (17 May 1926 – 11 February 1981) was a German-born British professor of chemistry. In 1960, he was awarded the Israel Prize for his contributions to science. Biography Franz Sondheimer was born in Stuttgart on 17 May 1926, the second son of Max and Ida Sondheimer. His father ran the family glue manufacturing business. His elder brother, Ernst, was Professor of Mathematics at Westfield College. Having business connections in England, Max Sondheimer managed to get his family to London in September 1937. Sondheimer, knowing no English, began his schooling in England first at Southend and then at Hailey School in Bournemouth. In 1940, having passed Common Entrance, he attended the part of Highgate School remaining in London, where he obtained School Certificate in nine subjects in 1942. A little over a year later he gained entrance to Imperial College, where he studied until the end of the war, coming top of his year in the final examination. He was awarded a P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillic Acid
Penicillic acid is a mycotoxin that is produced by ''Aspergillus flavus'' and ''Penicillium roqueforti'' mold. It is also the major product of acid degradation of penicillin. Its first practical synthesis was reported in 1947 by Ralph Raphael, who had worked on penicillin during World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin .... References Mycotoxins Furanones {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial Chemical Industries
Imperial Chemical Industries (ICI) was a British chemical company. It was, for much of its history, the largest manufacturer in Britain. It was formed by the merger of four leading British chemical companies in 1926. Its headquarters were at Millbank in London. ICI was a constituent of the FT 30 and later the FTSE 100 indices. ICI made general chemicals, plastics, paints, pharmaceuticals and speciality products, including food ingredients, speciality polymers, electronic materials, fragrances and flavourings. In 2008, it was acquired by AkzoNobel, which immediately sold parts of ICI to Henkel and integrated ICI's remaining operations within its existing organisation. History Development of the business (1926–1944) The company was founded in December 1926 from the merger of four companies: Brunner Mond, Nobel Explosives, the United Alkali Company, and British Dyestuffs Corporation. It established its head office at Millbank in London in 1928. Competing with DuPont a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
May & Baker
May & Baker was a British chemical company founded by John May and William Gerrard Baker in Wandsworth, London in 1839. They initially specialized in the manufacture of chemicals derived from mercury and bismuth. Over the years they diversified into other chemical fields including photographic chemicals, pharmaceuticals, agrochemicals, and chemicals for research and development. The company was bought by Établissements Poulenc Frères (later to become Société des Usines Chimiques Rhône-Poulenc) in 1922, and subsequently moved to Dagenham, Essex, although it continued to trade under the May & Baker name. During this time May & Baker branched into pharmaceuticals, with one of their major discoveries being sulphapyridine (M&B 693), first produced in 1937. This compound, May & Baker's most famous product, was one of the first generation of sulfonamide antibiotics. During WW2, M&B 693 saved many thousands of lives, including Sir Winston Churchill who was treated with it for p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin A
Vitamin A is a fat-soluble vitamin and an essential nutrient for humans. It is a group of organic compounds that includes retinol, retinal (also known as retinaldehyde), retinoic acid, and several provitamin A carotenoids (most notably beta-carotene ²-carotene. Vitamin A has multiple functions: it is essential for embryo development and growth, for maintenance of the immune system, and for vision, where it combines with the protein opsin to form rhodopsin the light-absorbing molecule necessary for both low-light (scotopic vision) and color vision. Vitamin A occurs as two principal forms in foods: A) retinol, found in animal-sourced foods, either as retinol or bound to a fatty acid to become a retinyl ester, and B) the carotenoids alpha-carotene, β-carotene, gamma-carotene, and the xanthophyll beta-cryptoxanthin (all of which contain β-ionone rings) that function as provitamin A in herbivore and omnivore animals which possess the enzymes that cleave and convert provi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tottenham
Tottenham () is a town in North London, England, within the London Borough of Haringey. It is located in the ceremonial county of Greater London. Tottenham is centred north-northeast of Charing Cross, bordering Edmonton to the north, Walthamstow, across the River Lea, to the east, and Stamford Hill to the south, with Wood Green and Harringay to the west. The area rapidly expanded in the late-19th century, becoming a working-class suburb of London following the advent of the railway and mass development of housing for the lower-middle and working classes. It is the location of Tottenham Hotspur Football Club, founded in 1882. The parish of Tottenham was granted urban district status in 1894 and municipal borough status in 1934. Following the Second World War, the area saw large-scale development of council housing, including tower blocks. Until 1965 Tottenham was in the historic county of Middlesex. In 1965, the borough of Tottenham merged with the municipal boroughs of Ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wesley College, Dublin
Wesley College is an independent co-educational secondary school for day and boarding students in Ballinteer, Dublin, Ireland. Wesley College is under the control of a Board of Governors, appointed each year by the Methodist Church in Ireland. Wesley College was founded on 1 October 1845 and counts two Nobel laureates among its alumni. Strong emphasis is put on religious education for all denominations and both extra-curricular activities and sport play an important part in this school. The college offers pupils an opportunity to explore the humanities, sciences, technology, business studies, English literature, music and the arts. Wesley College offers a range of extracurricular and sporting activities in the belief that these assist a "sound general education and contribute to the whole person". History Origins On 16 May 1844, a gathering of men met in Belfast and agreed to form a Wesleyan Proprietary Grammar School in Ireland "for the purpose of affording a thorough literary, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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