Radula Marginata
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Radula Marginata
''Radula marginata'', or Wairuakohu, is a species of plant in the genus ''Radula'', a genus of liverworts. It is endemic to New Zealand. It has been found to contain cannabinoids. Cannabinoids Users smoking the plant have experienced different effects. The cannabinoid is not THC, the main psychoactive chemical in cannabis, but it is of similar molecular structure. The liverwort contains perrottetinene and perrottetinenic acid. The quantity of cannabinoid present is much less than in cannabis. Perrottetinene has been shown to be a moderately potent CB1 agonist leading to mild psychoactive effects in mice. Legal status The liverwort grows as a common weed. Owning, growing and distributing the liverwort is legal. ''Radula marginata'' may have been used in rongoā refers to the traditional Māori medicinal practices in New Zealand. Rongoā was one of the Māori cultural practices targeted by the Tohunga Suppression Act 1907, until lifted by the Maori Welfare Act 1962. I ...
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Radula (plant)
''Radula'' is a genus of Marchantiophyta, liverwort, and is the only genus in family Radulaceae. It is a leafy liverwort. The appearance of the plants are as a scaly, green surface on the trunk of a tree, log or rock in a sheltered, moist out-door environment. The leaves are rounded, overlapping and consist of two unequal lobes. The smaller lobe is folded beneath the larger one. The oldest fossil species is ''Radula cretacea'' from the Cenomanian aged Burmese amber of Myanmar, belonging to the subgenus ''Odontoradula.'' Molecular evidence suggests that the genus arose during the Triassic, around 227.8 Ma, and the crown group began to diversify during the Early Jurassic, around 176.3 Ma. Species include: * ''Radula boninensis'' * ''Radula carringtonii'' J.B.Jack * ''Radula cavifolia'' * ''Radula complanata'' * ''Radula deflexilobula'' Promma, L.N.Zhang et R.L.Zhu * ''Radula demissa'' M.A.M.Renner, 2013 * ''Radula javanica'' * ''Radula jonesii'' Bouman, Dirkse & Yamada * ''Radula ...
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Marchantiophyta
The Marchantiophyta () are a division of non-vascular land plants commonly referred to as hepatics or liverworts. Like mosses and hornworts, they have a gametophyte-dominant life cycle, in which cells of the plant carry only a single set of genetic information. It is estimated that there are about 9000 species of liverworts. Some of the more familiar species grow as a flattened leafless thallus, but most species are leafy with a form very much like a flattened moss. Leafy species can be distinguished from the apparently similar mosses on the basis of a number of features, including their single-celled rhizoids. Leafy liverworts also differ from most (but not all) mosses in that their leaves never have a costa (present in many mosses) and may bear marginal cilia (very rare in mosses). Other differences are not universal for all mosses and liverworts, but the occurrence of leaves arranged in three ranks, the presence of deep lobes or segmented leaves, or a lack of clearly diff ...
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New Zealand
New Zealand ( mi, Aotearoa ) is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and over 700 smaller islands. It is the sixth-largest island country by area, covering . New Zealand is about east of Australia across the Tasman Sea and south of the islands of New Caledonia, Fiji, and Tonga. The country's varied topography and sharp mountain peaks, including the Southern Alps, owe much to tectonic uplift and volcanic eruptions. New Zealand's capital city is Wellington, and its most populous city is Auckland. The islands of New Zealand were the last large habitable land to be settled by humans. Between about 1280 and 1350, Polynesians began to settle in the islands and then developed a distinctive Māori culture. In 1642, the Dutch explorer Abel Tasman became the first European to sight and record New Zealand. In 1840, representatives of the United Kingdom and Māori chiefs ...
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Cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary intoxicating compound in cannabis. Cannabidiol (CBD) is a major constituent of temperate Cannabis plants and a minor constituent in tropical varieties. At least 113 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin. It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort, and earlier in Echinacea. Phytocannabinoids are multi-ring phenolic compounds structurally related to THC, but endocannabinoids are fatty acid derivatives. Nonclassical synthetic cannabinoids (cannabimimetics) include amin ...
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Tetrahydrocannabinol
Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC'' usually refers to the Delta-9-THC isomer with chemical name (−)-''trans''-Δ9-tetrahydrocannabinol. THC is a lipid found in cannabis and, like most pharmacologically active secondary metabolites of plants, it is assumed to be involved in the plant's evolutionary adaptation, putatively against insect predation, ultraviolet light, and environmental stress. THC was first discovered and isolated by Israeli chemist Raphael Mechoulam in Israel in 1964. It was found that, when smoked, THC is absorbed into the bloodstream and travels to the brain, attaching itself to endocannabinoid receptors located in the cerebral cortex, cerebellum, and basal ganglia. These are the parts of the brain responsible for thinking, memory, pleasure, coordination a ...
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Cannabis (drug)
Cannabis, also known as marijuana among List of names for cannabis, other names, is a psychoactive drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both Recreational marijuana, recreational and Entheogenic use of cannabis, entheogenic purposes and in various traditional medicines for centuries. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used by Cannabis smoking, smoking, Vaporizer (inhalation device), vaporizing, Cannabis edible, within food, or Tincture of cannabis, as an extract. Cannabis has various effects of cannabis, mental and physical effects, which include euphoria, altered states of mind and Cannabis and time perception, sense of time, difficulty concentrating, Cannabis and memory, impaired short-term memory, impaired motor skill, body mo ...
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Perrottetinene
Perrottetinene is a naturally occurring cannabinoid compound found in liverworts from the genus ''Radula'' native to Japan, New Zealand and Costa Rica, namely '' Radula perrottetii'', ''Radula marginata'' and ''Radula laxiramea'', along with a number of similar compounds. Its chemical structure closely resembles that of THC, the main active component of marijuana but with a ''cis'' rather than ''trans'' conformation. The absolute configuration of perrottetinene was established in 2008 by an enantioselective total synthesis. In 2018, a study showed that perrottetinene is moderately psychoactive through activation of the cannabinoid receptor 1. The same study also reported reduced prostaglandin D2 Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large a ... and E2 brain concentrations in mice ...
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Perrottetinene
Perrottetinene is a naturally occurring cannabinoid compound found in liverworts from the genus ''Radula'' native to Japan, New Zealand and Costa Rica, namely '' Radula perrottetii'', ''Radula marginata'' and ''Radula laxiramea'', along with a number of similar compounds. Its chemical structure closely resembles that of THC, the main active component of marijuana but with a ''cis'' rather than ''trans'' conformation. The absolute configuration of perrottetinene was established in 2008 by an enantioselective total synthesis. In 2018, a study showed that perrottetinene is moderately psychoactive through activation of the cannabinoid receptor 1. The same study also reported reduced prostaglandin D2 Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large a ... and E2 brain concentrations in mice ...
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Cannabinoid Receptor Type 1
Cannabinoid receptor type 1 (CB1), also known as cannabinoid receptor 1, is a G protein-coupled cannabinoid receptor that in humans is encoded by the ''CNR1'' gene. The human CB1 receptor is expressed in the peripheral nervous system and central nervous system. It is activated by: endocannabinoids, a group of retrograde neurotransmitters that include anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids, such as the compound THC which is an active ingredient of the psychoactive drug cannabis; and, synthetic analogs of THC. CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV). The primary endogenous agonist of the human CB1 receptor is anandamide. Structure The CB1 receptor shares the structure characteristic of all G-protein-coupled receptors, possessing seven transmembrane domains connected by three extracellular and three intracellular loops, an extracellular N-terminal tail, and an intracellular C-terminal tail. The receptor may exist ...
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Weed
A weed is a plant considered undesirable in a particular situation, "a plant in the wrong place", or a plant growing where it is not wanted.Harlan, J. R., & deWet, J. M. (1965). Some thoughts about weeds. ''Economic botany'', ''19''(1), 16-24. This introduces the concept of humans and their goals in a particular setting.Holzner, W., & Numata, M. (Eds.). (2013). ''Biology and ecology of weeds'' (Vol. 2). Springer Science & Business Media. The concept of weeds is particularly significant in agriculture, where the aim is growing crops or pastures of a single species, or a mixture of a few desired species. In such environments, other plant species are considered undesirable and therefore a weed. Besides, some weeds have undesirable characteristics making them a plant pest in most human settings.Harlan, J. R., & deWet, J. M. (1965). Some thoughts about weeds. ''Economic botany'', ''19''(1), 16-24.Holzner, W., & Numata, M. (Eds.). (2013). ''Biology and ecology of weeds'' (Vol. 2). Spri ...
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Rongoā
refers to the traditional Māori medicinal practices in New Zealand. Rongoā was one of the Māori cultural practices targeted by the Tohunga Suppression Act 1907, until lifted by the Maori Welfare Act 1962. In the later part of the 20th century there was renewed interest in Rongoā as part of a broader Māori renaissance. Rongoā can involve spiritual, herbal and physical components. Herbal aspects used plants such as harakeke, kawakawa, rātā, koromiko, kōwhai, kūmarahou, mānuka, tētēaweka and rimu ''Dacrydium cupressinum'', commonly known as rimu, is a large evergreen coniferous tree endemic to the forests of New Zealand. It is a member of the southern conifer group, the podocarps. The Māori name ''rimu'' comes from the Polynesian ....Franchelle Ofsoske-Wyber. The Sacred Plant Medicine of Aotearoa. References Further reading Mapping the themes of Maori talk about healthAcknowledging the Māori cultural values and beliefs embedded in rongoā Māori ...
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Porellales
Porellales is an order of liverworts. Taxonomy * Jubulineae Müller 1909 ** Frullaniaceae Lorch 1914 *** '' Frullania'' Raddi 1818a 'Amphijubula'' Schuster 1970a; ''Schusterella">Amphijubula.html" ;"title="'Amphijubula">'Amphijubula'' Schuster 1970a; ''Schusterella'' Hattori, Sharp & Mizutani 1972; ''Steerea'' Hattori & Kamimura 1971; ''Mylia'' Leman 1825 non Gray 1821] ** Jubulaceae von Klinggräff 1858 *** ''Jubula (plant), Jubula'' Dumortier 1822 nom. cons. non Bates 1929 Salviatus.html"_;"title="'Salviatus">'Salviatus''_Gray_1821***_''Neohattoria.html" ;"title="Salviatus">'Salviatus'' Gray 1821">Salviatus.html" ;"title="'Salviatus">'Salviatus'' Gray 1821*** ''Neohattoria">Salviatus">'Salviatus'' Gray 1821">Salviatus.html" ;"title="'Salviatus">'Salviatus'' Gray 1821*** ''Neohattoria'' Kamimura 1962 [''Hattoria'' Kamimura 1961 non Schuster 1961] *** ''Nipponolejeunea'' Hattori 1944d ** Lejeuneaceae Cavers 1910 [Metzgeriopsaceae] *** Lejeuneoideae **** Brachiolejeuneeae *** ...
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