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Rs6295
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene. It is one of the most investigated SNPs of its gene. The C-allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian race, Caucasian. The effect of the SNP on the binding potential of the human 5-HT1A receptor, 5-HT1A neuroreceptor has been assessed with positron emission tomography and the WAY-100635 radioligand, with a study reporting no apparent influence from the SNP. Disorders The SNP has been investigated for association with suicide attempts, and psychiatric disorders. One study found an association of the variant with schizophrenia. Some studies associate the G-allele or GG-genotype with major depression, depression. Not all studies show associations between the disorder and the G-allele. In one study of premenstrual dysphoric disorder C/C was found as the high-risk genotype. Several studies have examine the SNP association with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, at a specific base position in the human genome, the G nucleotide may appear in most individuals, but in a minority of individuals, the position is occupied by an A. This means that there is a SNP at this specific position, and the two possible nucleotide variations – G or A – are said to be the alleles for this specific position. SNPs pinpoint differences in our susceptibility to a wide range of diseases, for example age-related macular degeneration (a common SNP in the CFH gene is associated with increased risk of the disease) or nonalcoholic fatty liver disease (a SNP in the PNPLA3 gene is associated with incre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Depression
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-III), and has become widely used since. The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by relatives or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time of onset is in a person's 20s, with females affected about twice as often as males. The course of the disorder varies widely, from one epis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mood Disorder
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature. The classification is in the '' Diagnostic and Statistical Manual of Mental Disorders'' (DSM) and International Classification of Diseases (ICD). Mood disorders fall into seven groups, including; abnormally elevated mood, such as mania or hypomania; depressed mood, of which the best-known and most researched is major depressive disorder (MDD) (alternatively known as clinical depression, unipolar depression, or major depression); and moods which cycle between mania and depression, known as bipolar disorder (BD) (formerly known as manic depression). There are several sub-types of depressive disorders or psychiatric syndromes featuring less severe symptoms such as dysthymic disorder (similar to MDD, but longer lasting and more persistent, though often milder) and cyclothymic disorder (sim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-transcendence
Self-transcendence is a personality trait that involves the expansion of personal boundaries, including, potentially, experiencing spiritual ideas such as considering oneself an integral part of the universe. Several psychologists, including Viktor Frankl, Abraham Maslow, Pamela G. Reed, C. Robert Cloninger, Lars Tornstam, and Scott Barry Kaufman have made contributions to the theory of self-transcendence. Self-transcendence is distinctive as the first trait concept of a spiritual nature to be incorporated into a major theory of personality. Self-transcendence is one of the "character" dimensions of personality assessed in Cloninger's Temperament and Character Inventory. It is also assessed by the Self-Transcendence Scale and the Adult Self-Transcendence Inventory. Nature of the trait Several overlapping definitions of self-transcendence have been given. Viktor Frankl wrote, "The essentially self-transcendent quality of human existence renders man ''a being reaching out beyo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temperament And Character Inventory
The Temperament and Character Inventory (TCI) is an inventory for personality traits devised by Cloninger et al. It is closely related to and an outgrowth of the Tridimensional Personality Questionnaire (TPQ), and it has also been related to the dimensions of personality in Zuckerman's alternative five and Eysenck's models and those of the five factor model. TCI operates with seven dimensions of personality traits: four so-called ''temperaments'' * Novelty Seeking (NS) * Harm Avoidance (HA) * Reward Dependence (RD) * Persistence (PS) and three so-called ''characters'' * Self-Directedness (SD) * Cooperativeness (CO) * Self-Transcendence (ST) Each of these traits has a varying number of subscales. The dimensions are determined from a 240-item questionnaire. The TCI is based on a psychobiological model that attempts to explain the underlying causes of individual differences in personality traits. Versions Originally developed in English, TCI has been translated to other l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Neural Transmission
The ''Journal of Neural Transmission'' is a monthly peer-reviewed medical journal covering clinical neurology and translational neuroscience. It was established in 1950 by Carmen Coronini and Alexander Sturm as ''Acta Neurovegetativa''. It was renamed to the ''Journal of Neuro-Visceral Relations'' in 1968 and to its current title in 1972. From 1989 to 1995, the journal was published in two sections: a "general section" and a "Parkinson's disease and dementia section." The editor-in-chief is Peter Riederer. According to the ''Journal Citation Reports'', the journal has a 2019 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 3.505. References External links * Neurology journals Publications established in 1950 Monthly journals Springer Science+Business Media a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harm Avoidance
Harm avoidance (HA) is a personality trait characterized by excessive worrying; pessimism; shyness; and being fearful, doubtful, and easily fatigued. In MRI studies HA was correlated with reduced grey matter volume in the orbito-frontal, occipital and parietal regions. Harm avoidance is a temperament assessed in the Temperament and Character Inventory (TCI), its revised version (TCI-R) and the Tridimensional Personality Questionnaire (TPQ) and is positively related to the trait neuroticism and inversely to extraversion in the Revised NEO Personality Inventory and the Eysenck Personality Questionnaire. Researchers have contended that harm avoidance represents a composite personality dimension with neurotic introversion at one end of the spectrum and stable extraversion at the other end. Harm avoidance has also been found to have moderate inverse relationships with conscientiousness and openness to experience in the five factor model. The HA of TPQ and TCI-R has four subscales: # ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tridimensional Personality Questionnaire
Tridimensional Personality Questionnaire (TPQ) is a personality test. It was devised by C. Robert Cloninger. A newer version of the questionnaire is called Temperament and Character Inventory. As the name indicates TPQ seeks to measure three dimensions (traits) of the personality. These personality traits are novelty seeking, harm avoidance and reward dependence. Each have four subscales. There are 100 true-false questions which form the basis for the computation of the traits. The personality test also exists in Chinese, French and German versions. Neurobiology Cloninger suggested that the three dimensions, novelty seeking, harm avoidance, and reward dependence, were correlated with low basal dopaminergic activity, high serotonergic activity, and low basal noradrenergic activity, respectively. Much research has gone into examining these links, e.g., with personality genetics. References Other * {{Cite journal , author = C. R. Cloninger , title = A systematic meth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroticism
In the study of psychology, neuroticism has been considered a fundamental personality trait. For example, in the Big Five approach to personality trait theory, individuals with high scores for neuroticism are more likely than average to be moody and to experience such feelings as anxiety, worry, fear, anger, frustration, envy, jealousy, guilt, depressed mood, and loneliness. Such people are thought to respond worse to stressors and are more likely to interpret ordinary situations, such as minor frustrations, as appearing hopelessly difficult. People with high scores on the neuroticism index are thought to be at risk of developing common mental disorders ( mood disorders, anxiety disorders, and substance use disorders have been studied), and the sorts of symptoms traditionally referred to as "neuroses". Definition Neuroticism is a trait in many models within personality theory, but there is significant disagreement on its definition. It is sometimes defined as a tendency ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NEO PI-R
The Revised NEO Personality Inventory (NEO PI-R) is a personality inventory that assesses an individual on five dimensions of personality, the so-called Big Five personality traits. These traits are openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. In addition, the NEO PI-R also reports on six subcategories of each Big Five personality trait (called facets). Historically, development of the Revised NEO PI-R began in 1978 when Costa and McCrae published a personality inventory. The researchers later published three updated versions of their personality inventory in 1985, 1992, and 2005. These were called the NEO PI, NEO PI-R (or Revised NEO PI), and NEO PI-3, respectively. The revised inventories feature updated vocabulary that could be understood by adults of any education level, as well as children. The inventories have both longer and shorter versions, with the full NEO PI-R consisting of 240 items and providing detailed facet scores. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personality Trait
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality. Trait theorists are primarily interested in the measurement of ''traits'', which can be defined as habitual patterns of behaviour, thought, and emotion. According to this perspective, traits are aspects of personality that are relatively stable over time, differ across individuals (e.g. some people are outgoing whereas others are not), are relatively consistent over situations, and influence behaviour. Traits are in contrast to states, which are more transitory dispositions. In some theories and systems, traits are something a person either has or does not have, but in many others traits are dimensions such as extraversion vs. introversion, with each person rating somewhere along this spectrum. There are two approaches to define traits: as internal causal properties or as purely descriptive summaries. The internal causal definition states that traits influence our beha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common Side effect, side-effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, sexual dysfunction, and emotional blunting. There is a slight increased risk of suicidal thinking and behavior when taken by children, adolescents, and young adults. Antidepressant discontinuation syndrome, Discontinuation syndrome may occur after stopping any antidepressant which resembles recurrent depression. Some research regarding the effectiveness of antidepressants for depression in adults has found benefits, whilst other research has not. Evidence of benefit in children and adolescents is unclear. The twenty-one most commonly prescribed antidepressant medications are more effective than placebo for the short-term (acute) treatments of adults with major depressive disorder. There is debate in the medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
