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Robert C. Bast, Jr.
Robert Clinton Bast Jr., (born December 8, 1943) is an American physician-scientist who is currently Vice President for Translational Research at the University of Texas M.D. Anderson Cancer Center. Bast is best known for the discovery of CA125, a serum biomarker for ovarian cancer that has contributed to the care of ovarian cancer patients worldwide. His research spans early detection, enhancing chemotherapy and understanding regulation of dormancy and the role of autophagy Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent re ... in breast and ovarian cancer. References {{DEFAULTSORT:Bast, Robert C. 1943 births Wesleyan University alumni University of Texas MD Anderson Cancer Center faculty Harvard Medical School alumni Living people ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Texas MD Anderson Cancer Center
The University of Texas MD Anderson Cancer Center (colloquially MD Anderson Cancer Center) is a comprehensive cancer center in Houston, Texas. It is the largest cancer center in the U.S. and one of the original three comprehensive cancer centers in the country. It is both a degree-granting academic institution and a cancer treatment and research center located at the Texas Medical Center in Houston. It is affiliated with The University of Texas Health Science Center at Houston. According to Newsweek, MD Anderson Cancer Center is considered the best hospital in the world for oncology and related cancer treatment. History The cancer center is named after Monroe Dunaway Anderson, a banker and cotton trader from Jackson, Tennessee. He was a member of a business partnership with his brother-in-law Will Clayton. Their company became the largest cotton company in the world. Anderson feared that in the event of one of the partners' deaths, the company would lose a large amount of money t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wesleyan University
Wesleyan University ( ) is a Private university, private liberal arts college, liberal arts university in Middletown, Connecticut. Founded in 1831 as a Men's colleges in the United States, men's college under the auspices of the Methodist Episcopal Church and with the support of prominent residents of Middletown, the college was the first institution of higher education to be named after John Wesley, the founder of Methodism. It is now a secular institution. The college accepted female applicants from 1872 to 1909, but did not become fully co-educational until 1970. Before full co-education, Wesleyan alumni and other supporters of women's education established Connecticut College for women in 1912. Wesleyan, along with Amherst College, Amherst and Williams College, Williams colleges, is part of "The Little Three", also traditionally referred to as the Little Ivies. Its teams compete athletically as a member of the New England Small College Athletic Conference, NESCAC. Wesleyan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States, and provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering. History Harvard Medical School was founded on Septembe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Translational Research
Translational research (also called translation research, translational science, or, when the context is clear, simply translation) is research aimed at translating (converting) results in basic research into results that directly benefit humans. The term is used in science and technology, especially in biology and medical science. As such, translational research forms a subset of applied research. The term has been used most commonly in life-sciences and biotechnology but applies across the spectrum of science and humanities. In the context of biomedicine, translational research is also known as bench to bedside. In the field of education, it is defined as research which translates concepts to classroom practice. Critics of translational medical research (to the exclusion of more basic research) point to examples of important drugs that arose from fortuitous discoveries in the course of basic research such as penicillin and benzodiazepines. Other problems have stemmed from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CA-125
Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the ''MUC16'' gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign. Structure Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin. MUC16 is composed of three different domains: * An N-terminal domain * A tandem repeat domain * A C-terminal domain The N-terminal and tandem repeat domains are both entirely extracellular and highly O-glycosylated. All mucins contain a tandem repeat domain that has repeating amino acid sequences high in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
