RhoGAP

	RhoGAP RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/ Cdc42-like small GTPases. Human proteins containing this domain ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6; ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1; CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1; FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158; MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3; STARD13; STARD8 StAR-related lipid transfer domain protein 8 (STARD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP5 Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ''ARHGAP5'' gene. Function Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. Interactions ARHGAP5 has been shown to interact with Rnd1, Rnd2, Rnd3 and RHOA Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is .... References External links * Further reading * * * * * * * * * * * * * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP11B ''ARHGAP11B'' is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ''ARHGAP11B'' in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ''ARHGAP11B'' occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals. Structure ''ARHGAP11B'' encodes 267 amino acids. A truncated copy of '' ARHGAP11A'', which is found throughout the animal kingdom and encodes a Rho GTPase-activating-protein (RhoGAP domain), ''ARHGAP11B'' comprises most of the GAP domain (until lysine-220), followed by a novel C-terminal sequence that lacks the 756 C-terminal amino acids of ''ARHGAP11A''. Activity In contrast to full-length ''ARHGAP11A'' and ''ARHGAP11A 1-250'', ''ARHGAP11B'', like '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP10 Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene. Interactions ARHGAP1 has been shown to interact with: * BNIP2 * CDC42, and * RHOA Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is .... References External links * Further reading * * * * * * * * * * * * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP8 Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ''ARHGAP8'' gene. Function This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active ( GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be in ... variants encoding different isoforms have been descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP12 Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene. Interactions ARHGAP1 has been shown to interact with: * BNIP2 * CDC42, and * RHOA Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is .... References External links * Further reading * * * * * * * * * * * * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP4 Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ''ARHGAP4'' gene. It has been shown to regulate cell motility Motility is the ability of an organism to move independently, using metabolic energy. Definitions Motility, the ability of an organism to move independently, using metabolic energy, can be contrasted with sessility, the state of organisms th ... and axonal outgrowth in vitro. References External links * Further reading * * * * * * * * * * * * * * {{gene-X-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP1 Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene. Interactions ARHGAP1 has been shown to interact with: * BNIP2 * CDC42, and * RHOA Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is .... References External links * Further reading * * * * * * * * * * * * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP9 Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ''ARHGAP9'' gene. Function This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide s .... Multiple transcript variants encoding different isoforms have been found for this gene. References External links * * Further reading * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP24 Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ''ARHGAP24'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References External links * Further reading * * * * * * * {{gene-4-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP29 ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29, a protein that mediates the cyclical regulation of small GTP binding proteins such as RhoA. Function ARHGAP29 is expressed in the developing face and may act downstream of IRF6 in craniofacial development. Structure ARHGAP29 contains four domains including a coiled-coil region known to interact with Rap2, a C1 domain, the Rho GTPase domain, and a small C-terminal region that interacts with PTPL1. Clinical Significance The 1p22 locus containing ARHGAP29 was associated with nonsyndromic cleft lip/palate by genome wide association and meta-analysis. A follow-up study identified rare coding variants including a nonsense and a frameshift variant in patients with nonsyndromic cleft lip/palate. The finding of ARHGAP29's role in craniofacial development was discovered after the adjacent ABCA4 gene lacked functional or expression data to support it as the etiologic gene for nonsyndromic cle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ARHGAP19 Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ''ARHGAP19'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References External links * Further reading * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]