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RhTx
RhTx is a small peptide toxin from Chinese red-headed centipede, ''Scolopendra subspinipes mutilans'', also called the Chinese red-headed centipede. RhTx binds to the outer pore region of the temperature regulated TRPV1 ion channel, preferably in activated state, causing a downwards shift in the activation threshold temperature, which leads to the immediate onset of pungency, heat pain. Yang, S., Yang, F., Wei, N., Hong, J., Li, B., Luo, L., ... & Lai, R. (2015). ''A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1''. Nature Communications, 6. . Sources RhTx is a component of the venom of the Chinese red-headed centipede, ''S. subspinipes mutilans'', also called the Chinese red-headed centipede. Chemistry RhTx is a small peptide toxin, with a compact 3D-structure. The gene encoding for RhTx translates into a 69 amino acid peptide that shows no homology to any known animal toxin. This peptide, after post- translational modifications, yields ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Red-headed Centipede
The Chinese red-headed centipede, also known as the Chinese red head, (''Scolopendra subspinipes mutilans'') is a centipede from East Asia and Australasia. It averages 20 cm (8 in) in length and lives in damp environments. In ancient Chinese traditions, this centipede is used for its healing properties. Putting a Chinese red head on a rash or other skin-disease is said to speed up the healing process. The roasted dry centipede is pulverized and used in Korea for the treatment of back pain, furuncles, and sores. ''S. s. mutilans'' is known for harbouring little aggression to other centipedes, a trait very rare amongst giant centipedes, and allows it to be kept communally. Antimicrobial activities of the identified compounds were reported against Gram-positive and Gram-negative bacteria, fungi, viruses, and parasites, that possibly explain centipede's survival in harsh and polluted environments. Females are incubator mothers, guarding the eggs by wrapping their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
