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Reminyl
Galantamine is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. It is an alkaloid that has been isolated from the bulbs and flowers of ''Galanthus nivalis'' (Common snowdrop), ''Galanthus caucasicus'' (Caucasian snowdrop), ''Galanthus woronowii'' (Voronov's snowdrop), and some other members of the family ''Amaryllidaceae'', such as ''Narcissus'' (daffodil), ''Leucojum aestivum'' (snowflake), and ''Lycoris'' including ''Lycoris radiata'' (red spider lily). It can also be produced synthetically. Studies of usage in modern medicine began in the Soviet Union in the 1950s. Galantamine was isolated for the first time from bulbs of ''Galanthus nivalis'' (common snowdrop) by the Bulgarian chemist D. Paskov and his team in 1956. The active ingredient was extracted, identified, and studied, in particular in relation to its acetylcholinesterase (AChE)-inhibiting properties. The first industrial process was developed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Administration
Oral administration is a route of administration where a substance is taken through the mouth. Per os abbreviated to P.O. is sometimes used as a direction for medication to be taken orally. Many medications are taken orally because they are intended to have a systemic effect, reaching different parts of the body via the bloodstream, for example. Oral administration can be easier and less painful than other routes, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients willing and able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galantamine Total Synthesis
The article concerns the total synthesis of galanthamine, a drug used for the treatment of mild to moderate Alzheimer's disease. The natural source of galantamine are certain species of daffodil and because these species are scarce and because the isolation of galanthamine from daffodil is expensive (a 1996 figure specifies 50,000 US dollar per kilogram, the yield from daffodil is 0.1–0.2% dry weight) alternative synthetic sources are under development by means of total synthesis. Outline In 1962 racemic galanthamine and epi-galanthamine were prepared by organic reduction of racemic narwedine by D. H. R. Barton. Narwedine is the related enone (galanthamine the allyl alcohol) obtained in an oxidative coupling. Chemical yield: 1.4%. In addition they isolated (−)-narwardine by chiral resolution from a mixture of racemix narwedine and 0.5 equivalents of (+)-galanthamine. In this way they were able to obtain (−)galanthamine again by reduction In 1976 Kametani obtained both gala ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movement of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, sweat glands, and many other parts of the body. In broad terms, anticholinergics are divided into two categories in accordance with their specific targets in the central and peripheral nervous system and at the neuromuscular junction: antimuscarinic agents, and antinicotinic agents ( ganglionic blockers, neuromuscular blockers). The term "anticholinergic" is typically used to refer to antimuscarinics which competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delirium
Delirium (also known as acute confusional state) is an organically caused decline from a previous baseline of mental function that develops over a short period of time, typically hours to days. Delirium is a syndrome encompassing disturbances in attention, consciousness, and cognition. It may also involve other neurological deficits, such as psychomotor disturbances (e.g. hyperactive, hypoactive, or mixed), impaired sleep-wake cycle, emotional disturbances, and perceptual disturbances (e.g. hallucinations and delusions), although these features are not required for diagnosis. Delirium is caused by an acute organic process, which is a physically identifiable structural, functional, or chemical problem in the brain that may arise from a disease process ''outside'' the brain that nonetheless affects the brain. It may result from an underlying disease process (e.g. infection, hypoxia), side effect of a medication, withdrawal from drugs, over-consumption of alcohol, usage of hall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Datura Stramonium
''Datura stramonium'', known by the common names thorn apple, jimsonweed (jimson weed), devil's snare, or devil's trumpet, is a poisonous flowering plant of the nightshade family Solanaceae. It is a species belonging to the ''Datura'' genus and '' Daturae'' tribe. Its likely origin was in Central America, and it has been introduced in many world regions. It is an aggressive invasive weed in temperate climates across the world. ''D. stramonium'' has frequently been employed in traditional medicine to treat a variety of ailments. It has also been used as a hallucinogen (of the anticholinergic/antimuscarinic, deliriant type), taken entheogenically to cause intense, sacred or occult visions.Schultes, Richard Evans; Albert Hofmann (1979). ''Plants of the Gods: Origins of Hallucinogenic Use'' New York: McGraw-Hill. . It is unlikely ever to become a major drug of abuse owing to effects upon both mind and body frequently perceived as being highly unpleasant, giving rise to a state of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dioscorides
Pedanius Dioscorides ( grc-gre, Πεδάνιος Διοσκουρίδης, ; 40–90 AD), “the father of pharmacognosy”, was a Greek physician, pharmacologist, botanist, and author of ''De materia medica'' (, On Medical Material) —a 5-volume Greek encyclopedia about herbal medicine and related medicinal substances (a pharmacopeia), that was widely read for more than 1,500 years. For almost two millennia Dioscorides was regarded as the most prominent writer on plants and plant drugs. Life A native of Anazarbus, Cilicia, Asia Minor, Dioscorides likely studied medicine nearby at the school in Tarsus, which had a pharmacological emphasis, and he dedicated his medical books to Laecanius Arius, a medical practitioner there. Though he writes he lived a "soldier's life" or "soldier-like life", his pharmacopeia refers almost solely to plants found in the Greek-speaking eastern Mediterranean, making it likely that he served in campaigns, or travelled in a civilian capacity, less w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circe
Circe (; grc, , ) is an Magician (paranormal), enchantress and a minor goddess in ancient Greek mythology and Ancient Greek religion, religion. She is either a daughter of the Titans, Titan Helios and the Oceanid nymph Perse (mythology), Perse or the goddess Hecate and Aeëtes. Circe was renowned for her vast knowledge of potions and herbs. Through the use of these and a magic wand or staff, she would Shapeshifting, transform her enemies, or those who offended her, into animals. The best known of her legends is told in Homer's ''Odyssey'' when Odysseus visits her island of Aeaea on the way back from the Trojan War and she changes most of his crew into swine. He manages to persuade her to return them to human shape, lives with her for a year and has sons by her, including Latinus and Telegonus (son of Odysseus), Telegonus. Her ability to change others into animals is further highlighted by the story of Picus, an Italian king whom she turns into a woodpecker for resisting her adv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hermes
Hermes (; grc-gre, Ἑρμῆς) is an Olympian deity in ancient Greek religion and mythology. Hermes is considered the herald of the gods. He is also considered the protector of human heralds, travellers, thieves, merchants, and orators. He is able to move quickly and freely between the worlds of the mortal and the divine, aided by his winged sandals. Hermes plays the role of the psychopomp or "soul guide"—a conductor of souls into the afterlife. In myth, Hermes functions as the emissary and messenger of the gods, and is often presented as the son of Zeus and Maia, the Pleiad. Hermes is regarded as "the divine trickster," about which the '' Homeric Hymn to Hermes'' offers the most well-known account. His attributes and symbols include the herma, the rooster, the tortoise, satchel or pouch, talaria (winged sandals), and winged helmet or simple petasos, as well as the palm tree, goat, the number four, several kinds of fish, and incense. However, his main symbol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Odyssey
The ''Odyssey'' (; grc, Ὀδύσσεια, Odýsseia, ) is one of two major Ancient Greek literature, ancient Greek Epic poetry, epic poems attributed to Homer. It is one of the oldest extant works of literature still widely read by modern audiences. As with the ''Iliad'', the poem is divided into 24 books. It follows the Greek hero cult, Greek hero Odysseus, king of Homer's Ithaca, Ithaca, and his journey home after the Trojan War. After the war, which lasted ten years, his journey lasted for ten additional years, during which time he encountered many perils and all his crew mates were killed. In his absence, Odysseus was assumed dead, and his wife Penelope and son Telemachus had to contend with a Suitors of Penelope, group of unruly suitors who were competing for Penelope's hand in marriage. The ''Odyssey'' was originally composed in Homeric Greek in around the 8th or 7th century BCE and, by the mid-6th century BCE, had become part of the Greek literary canon. In Classic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homer
Homer (; grc, Ὅμηρος , ''Hómēros'') (born ) was a Greek poet who is credited as the author of the ''Iliad'' and the ''Odyssey'', two epic poems that are foundational works of ancient Greek literature. Homer is considered one of the most revered and influential authors in history. Homer's ''Iliad'' centers on a quarrel between King Agamemnon and the warrior Achilles during the last year of the Trojan War. The ''Odyssey'' chronicles the ten-year journey of Odysseus, king of Ithaca, back to his home after the fall of Troy. The poems are in Homeric Greek, also known as Epic Greek, a literary language which shows a mixture of features of the Ionic and Aeolic dialects from different centuries; the predominant influence is Eastern Ionic. Most researchers believe that the poems were originally transmitted orally. Homer's epic poems shaped aspects of ancient Greek culture and education, fostering ideals of heroism, glory, and honor. To Plato, Homer was simply the one who ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase
Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ... that catalysis, catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: : acetylcholine + H2O = choline + acetate It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate neurotransmission, synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. Enzyme structure and mechani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dimitar Paskov
Dimitar Paskov (, 18 October 1914, Gorno Brodi – 24 April 1986, Bulgaria) is a Bulgarian chemist who led the Sopharma team that extracted NivalinCHRUSCIEL, M. and VARAGIĆ, V. (1966), THE EFFECT OF GALANTAMINE ON THE BLOOD PRESSURE OF THE RAT. British Journal of Pharmacology and Chemotherapy, 26: 295–301. doi: 10.1111/j.1476-5381.1966.tb01908.x (Galantamine) in 1959. The original phytopreparation is an extract of the alkaloid from bulbs of Galanthus nivalis, common snowdrop. Galantamine hydrobromide (Nivalin) has formula C17H21NO3.HBr and molecular weight 386.3. References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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