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Recombinant Bovine Somatotropin
Bovine somatotropin or bovine somatotrophin (abbreviated bST and BST), or bovine growth hormone (BGH), is a peptide hormone produced by cows' pituitary glands. Like other hormones, it is produced in small quantities and is used in regulating metabolic processes. Recombinant bovine somatotropin (usually "rBST"), is a synthetic version of the bovine growth hormone given to dairy cattle by injection to increase milk production. Synthesis After the biotech company Genentech discovered and patented the gene for BST in the 1970s,Keith Schneider. 10 June 1990"Betting the Farm on Biotech." ''the New York Times'' it became possible to synthesize the hormone using recombinant DNA technology to create recombinant bovine somatotropin (rBST), recombinant bovine growth hormone (rBGH), or artificial growth hormone. Industrial production Four large pharmaceutical companies, Monsanto, American Cyanamid, Eli Lilly, and Upjohn, developed commercial rBST products and submitted them to the US Foo ...
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Holstein Dairy Cows
Holstein (; nds, label=Northern Low Saxon, Holsteen; da, Holsten; Latin and historical en, Holsatia, italic=yes) is the region between the rivers Elbe and Eider. It is the southern half of Schleswig-Holstein, the northernmost state of Germany. Holstein once existed as the German County of Holstein (german: Grafschaft Holstein, links=no; 811–1474), the later Duchy of Holstein (german: Herzogtum Holstein, links=no; 1474–1866), and was the northernmost territory of the Holy Roman Empire. The history of Holstein is closely intertwined with the history of the Danish Duchy of Schleswig ( da, Slesvig, links=no). The capital of Holstein is Kiel. Holstein's name comes from the Holcetae, a Saxon tribe mentioned by Adam of Bremen as living on the north bank of the Elbe, to the west of Hamburg. The name means "dwellers in the wood" (Northern Low Saxon: ; german: Holzsassen, links=no). History Origins After the Migration Period of the Early Middle Ages, Holstein was adjacent to t ...
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Lactation
Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The process of feeding milk in all animals (including humans) is called ''nursing'', and in humans it is also called ''breastfeeding''. Newborn infants often produce some milk from their own breast tissue, known colloquially as witch's milk. In most species, lactation is a sign that the female has been pregnant at some point in her life, although it can happen without pregnancy. Nearly every species of mammal has nipples; except for monotremes, egg-laying mammals, which instead release milk through ducts in the abdomen. In only one species of mammal, the Dayak fruit bat from Southeast Asia, is milk production a normal male function. ''Galactopoiesis'' is the maintenance of milk production. This stage requires prolactin. Oxytocin is critical for t ...
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Estrous Synchronization
In agriculture, estrous synchronization is used (particularly in the dairy and beef industries) to facilitate breeding by artificial insemination. Background The term “estrus” refers to the phase of the estrous cycle in which a sexually mature, non-pregnant female is receptive to sexual advances from the male³. Ovulation occurs at approximately this time. Estrous synchronisation is the process of targeting female mammals to come to heat within a short time frame (36 to 96 hours). This is achieved through the use of one or more hormones. Methods to improve our ability to synchronize the reproductive process and result in the ‘timed insemination’ without the detection of heat have been developed. These include the “Synch” protocols that involve the application of GnRH and PGF2α in various combinations. These “Synch” protocols may include: Select Synch, OvSynch, CoSynch, and Modified Select Synch The synchronization of the estrous cycle is commonly used in different ...
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National Agricultural Statistics Service
The National Agricultural Statistics Service (NASS) is the statistical branch of the U.S. Department of Agriculture and a principal agency of the U.S. Federal Statistical System. NASS has 12 regional offices throughout the United States and Puerto Rico and a headquarters unit in Washington, D.C. NASS conducts hundreds of surveys and issues nearly 500 national reports each year on issues including agricultural production, economics, demographics and the environment. NASS also conducts the United States Census of Agriculture every five years. History During the Civil War, USDA collected and distributed crop and livestock statistics to help farmers assess the value of the goods they produced. At that time, commodity buyers usually had more current and detailed market information than did farmers, a circumstance that often prevented farmers from getting a fair price for their goods. Producers in today's marketplace would be similarly handicapped were it not for the information provid ...
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United States Department Of Agriculture
The United States Department of Agriculture (USDA) is the United States federal executive departments, federal executive department responsible for developing and executing federal laws related to farming, forestry, rural economic development, and food. It aims to meet the needs of commercial farming and livestock food production, promotes agricultural trade and production, works to assure food safety, protects natural resources, fosters rural communities and works to end hunger in the United States and internationally. It is headed by the United States Secretary of Agriculture, Secretary of Agriculture, who reports directly to the President of the United States and is a member of the president's Cabinet of the United States, Cabinet. The current secretary is Tom Vilsack, who has served since February 24, 2021. Approximately 80% of the USDA's $141 billion budget goes to the Food and Nutrition Service (FNS) program. The largest component of the FNS budget is the Supplementa ...
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Upregulated
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus. The complementary process that involves increases of such components is called upregulation. An example of downregulation is the cellular decrease in the expression of a specific receptor in response to its increased activation by a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule. This is an example of a locally acting (negative feedback) mechanism. An example of upregulation is the response of liver cells exposed to such xenobiotic molecules as dioxin. In this situation, the cells increase their production of cytochrome P450 enzymes, which in turn increases degradation of these dioxin molecules. Downregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. Such an epigene ...
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Insulin-like Growth Factor
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. IGF1/GH axis The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (commonly referred to as IGF-1 or at times using Roman numerals as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and ...
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Udder
An udder is an organ formed of two or four mammary glands on the females of dairy animals and ruminants such as cattle, goats, and sheep. An udder is equivalent to the breast in primates and elephantine pachyderms. The udder is a single mass hanging beneath the animal, consisting of pairs of mammary glands with protruding teats. In cattle and camels, there are normally two pairs, in sheep, goats and deer, there is one pair, and in some animals, there are many pairs. In animals with udders, the mammary glands develop on the milk line near the groin, and mammary glands that develop on the chest (such as in humans and apes and elephants) are generally referred to as breasts. Udder care and hygiene in cows is important in milking, aiding uninterrupted and untainted milk production, and preventing mastitis. Products exist to soothe the chapped skin of the udder. This helps prevent bacterial infection, and reduces irritation during milking by the cups, and so the cow is less likely to ...
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Patrick Leahy
Patrick Joseph Leahy (; born March 31, 1940) is an American politician and attorney who is the senior United States senator from Vermont and serves as the president pro tempore of the United States Senate. A member of the Democratic Party, Leahy was first elected in 1974 and is in his eighth term. He is the chair of the Appropriations Committee, and served as president pro tempore from 2012 to 2015 and again since 2021. Upon Representative Don Young's death in March 2022, he became the most senior member of Congress. Leahy is also the last of the Senate's "Watergate Babies"—Democrats first elected to Congress in the wave election of 1974 that followed President Richard Nixon's resignation over the Watergate scandal. , Leahy is one of three members of Congress to have served during Gerald Ford's presidency and one of eight to have served during Jimmy Carter's. The dean of his state's congressional delegation, Leahy is Vermont's longest-serving U.S. senator, as well a ...
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Bioreactors
A bioreactor refers to any manufactured device or system that supports a biologically active environment. In one case, a bioreactor is a vessel in which a chemical reaction, chemical process is carried out which involves organisms or biochemistry, biochemically active chemical substance, substances derived from such organisms. This process can either be Aerobic organism, aerobic or Anaerobic organism, anaerobic. These bioreactors are commonly cylindrical, ranging in size from litres to cubic metres, and are often made of stainless steel. It may also refer to a device or system designed to grow Cell (biology), cells or Biological tissue, tissues in the context of cell culture. These devices are being developed for use in tissue engineering or biochemical engineering, biochemical/bioprocess engineering, bioprocess engineering. On the basis of mode of operation, a bioreactor may be classified as batch reactor, batch, fed-batch, fed batch or continuous reactor, continuous (e.g. a conti ...
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Escherichia Coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are harmless, but some serotypes ( EPEC, ETEC etc.) can cause serious food poisoning in their hosts, and are occasionally responsible for food contamination incidents that prompt product recalls. Most strains do not cause disease in humans and are part of the normal microbiota of the gut; such strains are harmless or even beneficial to humans (although these strains tend to be less studied than the pathogenic ones). For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by pathogenic bacteria. These mutually beneficial relationships between ''E. col ...
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Genetic Engineering
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome. An organism that is generated through genetic engineering is considered to be genetically modified (GM) an ...
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