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Rauvolfia Vomitoria
''Rauvolfia vomitoria'', the poison devil's-pepper, is a plant species in the genus ''Rauvolfia''. It is native from Senegal east to Sudan and Tanzania, south to Angola; and naturalized in China, Bangladesh, different ranges of Himalayan and Puerto Rico. The plant contains a number of compounds of interest to the pharmaceutical industry and is widely used in traditional medicine. Description ''Rauvolfia vomitoria'' is a small tree or large shrub, growing to high. The branches grow in whorls, and the leaves grow from swollen nodes in groups of three. The leaf blades are broadly lanceolate or elliptical, tapering to a long point. The small, fragrant flowers are followed by globular red fruit. All parts of the plant, except the mature wood, contain latex. Ecology This is a fast-growing tree that produces large quantities of seeds which are dispersed by birds. The seedlings and saplings are tolerant of shade and the tree regenerates after cutting or burning, soon forming dense th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adam Afzelius
Adam Afzelius (8 October 175020 January 1837) was a Swedish botanist and an apostle of Carl Linnaeus. Afzelius was born at Larv in Västergötland in 1750. He was appointed teacher of oriental languages at Uppsala University in 1777, and in 1785 demonstrator of botany. In 1793 he was elected a member of the Royal Swedish Academy of Sciences. In 1800, Adam Afzelius became member of the German Academy of Sciences Leopoldina. Between 1792 and 1796, as part of the Sierra Leone Company, he made two journeys to West Africa, where he reported on the geography, climate and natural resources of the region. While here, he also collected botanical specimens that were later acquired by Uppsala University.Afzelius, Adam (1750-1837) at JSTOR Global Plants In 1797-98 he acted as secretary of the Swedish |
Purgative
Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubricant and saline laxatives are used to evacuate the colon for rectal and bowel examinations, and may be supplemented by enemas under certain circumstances. Sufficiently high doses of laxatives may cause diarrhea. Some laxatives combine more than one active ingredient. Laxatives may be administered orally or rectally. Types Bulk-forming agents Bulk-forming laxatives, also known as roughage, are substances, such as fiber in food and hydrophilic agents in over-the-counter drugs, that add bulk and water to stools so that they can pass more easily through the intestines (lower part of the digestive tract). Properties * Site of action: small and large intestines * Onset of action: 12–72 hours * Examples: dietary fiber, Metamucil, Citru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoquinone
Benzoquinone (C6H4O2) is a quinone with a single benzene ring. There are 2 (out of 3 hypothetical) benzoquinones: * 1,4-Benzoquinone, most commonly, right image (also ''para''-benzoquinone, ''p''-benzoquinone, ''para''-quinone, or just quinone) * 1,2-Benzoquinone, less commonly, left image (also ''ortho''-benzoquinone, ''o''-benzoquinone, ''ortho''-quinone) *1,3-benzoquinone "does not exist, because its structure would be nonplanar and highly strained", though derivatives are known. An alkylated ''p''-benzoquinone has been found in the rhizomes of ''Iris kemaonensis''. See also * Arene substitution pattern Arene substitution patterns are part of organic chemistry IUPAC nomenclature and pinpoint the position of substituents other than hydrogen in relation to each other on an aromatic hydrocarbon. ''Ortho'', ''meta'', and ''para'' substitution * I ... References {{Chemistry index ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,6-Dimethoxybenzoquinone
2,6-Dimethoxybenzoquinone (2,6-DMBQ) is a chemical compound, classified as a benzoquinone, that has been found in ''Rauvolfia vomitoria'' and in ''Tibouchina pulchra''. Toxicity At physiological concentrations 2,6-dimethoxybenzoquinone is an antibacterial substance. At higher concentrations there is evidence that it is mutagenic,Brambilla G; Robbiano L; Cajelli E; Martelli A; Turmolini F; Mazzei M Cytotoxic, DNA-damaging and mutagenic properties of 2,6-dimethoxy-1,4-benzoquinone, formed by dimethophrine-nitrite interaction. The Journal of Pharmacology and Experimental Therapeutics (1988), 244(3), 1011-5 cytotoxic, genotoxic, and hepatotoxic Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn fro .... Some reports have challenged its mutagenicity and others exclude such a possibility.Int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ajmaline
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent. It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome. Individuals suffering from Brugada syndrome will be more susceptible to the arrhythmogenic effects of the drug, and this can be observed on an electrocardiogram as an ST elevation. The compound was first isolated by Salimuzzaman Siddiqui in 1931 from the roots of '' Rauvolfia serpentina''. He named it ''ajmaline'', after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia. Ajmaline can be found in most species of the genus '' Rauvolfia'' as well as ''Catharanthus roseus''. In addition to Southeast Asia, ''Rauvolfia'' species have also been found in tropical regions of India, Africa, South America, and some oceanic islands. Other indole alkaloids found in ''Rauvolfia'' include reserpine, ajmalicine, serpen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ajmalicine
Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raunatin, Saltucin Co, Salvalion, and Sarpan. It is an alkaloid found naturally in various plants such as ''Rauvolfia'' spp., ''Catharanthus roseus'', and ''Mitragyna speciosa''. Ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. Like corynanthine, it acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects. Additionally, it is a very strong inhibitor of the CYP2D6 liver enzyme, which is responsible for the breakdown of many drugs. Its binding affinity at this receptor is 3.30 nM. See also * Corynanthine * Rauwolscine * Spegatrine * Yo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deserpidine
Deserpidine (INN) or reserpidine (USAN) is an antihypertensive drug related to reserpine which occurs naturally in ''Rauvolfia ''Rauvolfia'' (sometimes spelled ''Rauwolfia'') is a genus of evergreen trees and shrubs, commonly known as devil peppers, in the family Apocynaceae. The genus is named to honor Leonhard Rauwolf. The genus can mainly be found in tropical reg ... spp.'' References Alkaloids found in Rauvolfia Antihypertensive agents Benzoate esters Tryptamine alkaloids Indoloquinolizines Quinolizidine alkaloids Monoamine-depleting agents Pyrogallol ethers VMAT inhibitors {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reserpinine
Rescinnamine, known by the brand names moderil, cinnasil, and anaprel, is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is a vinca alkaloid obtained from ''Rauvolfia serpentina'' and other species of ''Rauvolfia ''Rauvolfia'' (sometimes spelled ''Rauwolfia'') is a genus of evergreen trees and shrubs, commonly known as devil peppers, in the family Apocynaceae. The genus is named to honor Leonhard Rauwolf. The genus can mainly be found in tropical reg ...''. References Indoloquinolizines Tryptamine alkaloids Isoquinoline alkaloids ACE inhibitors Antihypertensive agents Alkaloids found in Rauvolfia Pyrogallol ethers Cinnamate esters Indole ethers at the benzene ring {{Antihypertensive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reserpine
Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. Although the use of reserpine as a solo drug has declined since it was first approved by the FDA in 1955, the combined use of reserpine and a thiazide diuretic or vasodilator is still recommended in patients who do not achieve adequate lowering of blood pressure with first-line drug treatment alone. The reserpine-hydrochlorothiazide combo pill was the 17th most commonly prescribed of the 43 combination antihypertensive pills available In 2012. The antihypertensive actions of reserpine are largely due to its antinoradrenergic effects, which are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodenticide
Rodenticides are chemicals made and sold for the purpose of killing rodents. While commonly referred to as "rat poison", rodenticides are also used to kill mice, squirrels, woodchucks, chipmunks, porcupines, nutria, beavers, and voles. Despite the crucial roles that rodents play in nature, there are times when they need to be controlled. Some rodenticides are lethal after one exposure while others require more than one. Rodents are disinclined to gorge on an unknown food (perhaps reflecting an adaptation to their inability to vomit), preferring to sample, wait and observe whether it makes them or other rats sick. This phenomenon of poison shyness is the rationale for poisons that kill only after multiple doses. Besides being directly toxic to the mammals that ingest them, including dogs, cats, and humans, many rodenticides present a secondary poisoning risk to animals that hunt or scavenge the dead corpses of rats. Classes of rodenticides Anticoagulants Anticoagulant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cassava
''Manihot esculenta'', common name, commonly called cassava (), manioc, or yuca (among numerous regional names), is a woody shrub of the spurge family, Euphorbiaceae, native to South America. Although a perennial plant, cassava is extensively cultivated as an annual agriculture, crop in tropical and subtropical regions for its edible starchy tuberous root, a major source of carbohydrates. Though it is often called ''yuca'' in parts of Spanish America and in the United States, it is not related to yucca, a shrub in the family Asparagaceae. Cassava is predominantly consumed in boiled form, but substantial quantities are used to extract cassava starch, called tapioca, which is used for food, animal feed, and industrial purposes. The Brazilian farinha, and the related ''garri'' of West Africa, is an edible coarse flour obtained by grating cassava roots, pressing moisture off the obtained grated pulp, and finally drying it (and roasting both in the case of farinha and garri). Cassav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
