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RI-1 (cell Line)
RI-1 may refer to: * Rhode Island's 1st congressional district Rhode Island's 1st congressional district is a congressional district in the U.S. state of Rhode Island. It includes all of Bristol and Newport counties, along with parts of Providence County, including most of the city of Providence. The di ... * RI-1 (chemical), an experimental oncology drug * U.S. Route 1 in Rhode Island, a portion of a north–south highway in the United States {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhode Island's 1st Congressional District
Rhode Island's 1st congressional district is a congressional district in the U.S. state of Rhode Island. It includes all of Bristol and Newport counties, along with parts of Providence County, including most of the city of Providence. The district is currently represented by Democrat David Cicilline. In 2010, it was the least populous congressional district in the country. History and composition Bristol County: Barrington, Bristol, and Warren. Newport County: Jamestown, Little Compton, Middletown, Newport, Portsmouth, and Tiverton. Providence County: Central Falls, Cumberland, East Providence, Lincoln, North Providence, North Smithfield, Pawtucket, Providence (part), Smithfield, and Woonsocket. Voter registration Recent results from statewide elections List of members representing the district Election history 2006 2008 2010 2012 2014 2016 2018 2020 2022 Historical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RI-1 (chemical)
RI-1 is a selective inhibitor of RAD51, which is a central gene molecule of homologous recombination, with IC50 ranging from 5 to 30 μM. Antitumor mechanism ''RAD51'' is a eukaryote gene, encoding RAD51 protein that participates in DNA damage induction and complex signal pathway of cell cycle checkpoint of homologous recombination in cells. However, over-expression of RAD51 may lead the occurrence and development progress of tumours and besides, the insensitivity of tumours to chemoradiotherapy. At present, over-expression of RAD51 has been found in many kinds of human cancers, such as breast cancer, lung cancer and ovarian cancer. RI-1 inhibits the over-expression of RAD51 in cancer cells by bonding covalently to the surface of RAD51 protein at Cys 319 and irreversibly loosen a protein-protein interface that is essential for filament formation and recombinase activity. Targeted drugs to RAD51 has the prospect to be a new generation of oncologic drugs, like RI-1. It is also a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
