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Quantum Microscopy
Quantum microscopy allows microscopic properties of matter and quantum particles to be measured and imaged. Various types of microscopy use quantum principles. The first microscope to do so was the scanning tunneling microscope, which paved the way for development of the photoionization microscope and the quantum entanglement microscope. Scanning tunneling The scanning tunneling microscope (STM) uses the concept of quantum tunneling to directly image atoms. A STM can be used to study the three-dimensional structure of a sample, by scanning the surface with a sharp, metal, conductive tip close to the sample. Such an environment is conducive to quantum tunneling: a quantum mechanical effect that occurs when electrons move through a barrier due to their wave-like properties. Tunneling depends on the thickness of the barrier; the Schrödinger equation gives the probability that a particle will be detected on the far side and, for a sufficiently thin barrier, predicts some electrons wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scanning Tunneling Microscope
A scanning tunneling microscope (STM) is a type of microscope used for imaging surfaces at the atomic level. Its development in 1981 earned its inventors, Gerd Binnig and Heinrich Rohrer, then at IBM Zürich, the Nobel Prize in Physics in 1986. STM senses the surface by using an extremely sharp conducting tip that can distinguish features smaller than 0.1 nm with a 0.01 nm (10 pm) depth resolution. This means that individual atoms can routinely be imaged and manipulated. Most microscopes are built for use in ultra-high vacuum at temperatures approaching zero kelvin, but variants exist for studies in air, water and other environments, and for temperatures over 1000 °C. STM is based on the concept of quantum tunneling. When the tip is brought very near to the surface to be examined, a bias voltage applied between the two allows electrons to tunnel through the vacuum separating them. The resulting ''tunneling current'' is a function of the tip position, applied ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aneta Stodolna
Aneta Sylwia Stodolna is a Polish physicist known for being the first person to successfully use a quantum microscope to image electrons in a hydrogen atom. Stodolna earned her Ph.D. from Radboud University Radboud University (abbreviated as RU, nl, Radboud Universiteit , formerly ''Katholieke Universiteit Nijmegen'') is a public research university located in Nijmegen, the Netherlands. The university bears the name of Saint Radboud, a 9th century D ... in 2014. References 21st-century Polish physicists Polish women physicists Year of birth missing (living people) Living people Radboud University Nijmegen alumni {{Poland-scientist-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optical Tweezer
Optical tweezers (originally called single-beam gradient force trap) are scientific instruments that use a highly focused laser beam to hold and move microscopic and sub-microscopic objects like atoms, nanoparticles and droplets, in a manner similar to tweezers. If the object is held in air or vacuum without additional support, it can be called optical levitation. The laser light provides an attractive or repulsive force (typically on the order of piconewtons), depending on the relative refractive index between particle and surrounding medium. Levitation is possible if the force of the light counters the force of gravity. The trapped particles are usually micron-sized, or even smaller. Dielectric and absorbing particles can be trapped, too. Optical tweezers are used in biology and medicine (for example to grab and hold a single bacterium, a cell like a sperm cell or a blood cell, or a molecule like DNA), nanoengineering and nanochemistry (to study and build materials from singl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Squeezed States Of Light
In quantum physics, light is in a '' squeezed state'' if its electric field strength ''Ԑ'' for some phases \vartheta has a quantum uncertainty smaller than that of a coherent state. The term ''squeezing'' thus refers to a reduced quantum uncertainty. To obey Heisenberg's uncertainty relation, a squeezed state must also have phases at which the electric field uncertainty is ''anti-squeezed'', i.e. larger than that of a coherent state. Since 2019, the gravitational-wave observatories LIGO and Virgo employ ''squeezed'' laser light, which has significantly increased the rate of observed gravitational-wave events. Quantum physical background An oscillating physical quantity cannot have precisely defined values at all phases of the oscillation. This is true for the electric and magnetic fields of an electromagnetic wave, as well as for any other wave or oscillation (see figure right). This fact can be observed in experiments and is described by quantum theory. For electromagne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gravitational Wave
Gravitational waves are waves of the intensity of gravity generated by the accelerated masses of an orbital binary system that propagate as waves outward from their source at the speed of light. They were first proposed by Oliver Heaviside in 1893 and then later by Henri Poincaré in 1905 as waves similar to electromagnetic waves but the gravitational equivalent. Gravitational waves were later predicted in 1916 by Albert Einstein on the basis of his general theory of relativity as ripples in spacetime. Later he refused to accept gravitational waves. Gravitational waves transport energy as gravitational radiation, a form of radiant energy similar to electromagnetic radiation. Newton's law of universal gravitation, part of classical mechanics, does not provide for their existence, since that law is predicated on the assumption that physical interactions propagate instantaneously (at infinite speed)showing one of the ways the methods of Newtonian physics are unable to explain ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photobleaching
In optics, photobleaching (sometimes termed fading) is the photochemical alteration of a dye or a fluorophore molecule such that it is permanently unable to fluoresce. This is caused by cleaving of covalent bonds or non-specific reactions between the fluorophore and surrounding molecules. Such irreversible modifications in covalent bonds are caused by transition from a singlet state to the triplet state of the fluorophores. The number of excitation cycles to achieve full bleaching varies. In microscopy, photobleaching may complicate the observation of fluorescent molecules, since they will eventually be destroyed by the light exposure necessary to stimulate them into fluorescing. This is especially problematic in time-lapse microscopy. However, photobleaching may also be used prior to applying the (primarily antibody-linked) fluorescent molecules, in an attempt to quench autofluorescence. This can help improve the signal-to-noise ratio. Photobleaching may also be exploited to study ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phototoxicity
Phototoxicity, also called photoirritation, is a chemically induced skin irritation, requiring light, that does not involve the immune system. It is a type of photosensitivity. The skin response resembles an exaggerated sunburn. The involved chemical may enter into the skin by topical administration or it may reach the skin via systemic circulation following ingestion or parenteral administration. The chemical needs to be "photoactive," which means that when it absorbs light, the absorbed energy produces molecular changes that cause toxicity. Many synthetic compounds, including drug substances like tetracyclines or fluoroquinolones, are known to cause these effects. Surface contact with some such chemicals causes photodermatitis; many plants cause phytophotodermatitis. Light-induced toxicity is a common phenomenon in humans; however, it also occurs in other animals. Scientific background A phototoxic substance is a chemical compound which becomes toxic when exposed to light. * So ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angular Resolution
Angular resolution describes the ability of any image-forming device such as an optical or radio telescope, a microscope, a camera, or an eye, to distinguish small details of an object, thereby making it a major determinant of image resolution. It is used in optics applied to light waves, in antenna theory applied to radio waves, and in acoustics applied to sound waves. The colloquial use of the term "resolution" sometimes causes confusion; when an optical system is said to have a high resolution or high angular resolution, it means that the perceived distance, or actual angular distance, between resolved neighboring objects is small. The value that quantifies this property, ''θ,'' which is given by the Rayleigh criterion, is low for a system with a high resolution. The closely related term spatial resolution refers to the precision of a measurement with respect to space, which is directly connected to angular resolution in imaging instruments. The Rayleigh criterion shows th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NOON State
In quantum optics, a NOON state or N00N state is a quantum-mechanical many-body Quantum entanglement, entangled state: : , \psi_\text \rangle = \frac, \, which represents a superposition of ''N'' particles in mode ''a'' with zero particles in mode ''b'', and vice versa. Usually, the particles are photons, but in principle any bosonic field can support NOON states. Applications NOON states are an important concept in quantum metrology and quantum sensing for their ability to make precision phase measurements when used in an optical Interferometry, interferometer. For example, consider the observable : A = , N,0\rangle\langle 0,N, + , 0,N\rangle\langle N,0, . \, The expectation value of A for a system in a NOON state switches between +1 and −1 when \theta changes from 0 to \pi/N. Moreover, the error in the phase measurement becomes : \Delta \theta = \frac = \frac. This is the so-called Heisenberg limit, and gives a quadratic improvement over the quantum limit, st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Differential Interference Contrast Microscopy
Differential interference contrast (DIC) microscopy, also known as Nomarski interference contrast (NIC) or Nomarski microscopy, is an optical microscopy technique used to enhance the contrast in unstained, transparent samples. DIC works on the principle of interferometry to gain information about the optical path length of the sample, to see otherwise invisible features. A relatively complex optical system produces an image with the object appearing black to white on a grey background. This image is similar to that obtained by phase contrast microscopy but without the bright diffraction halo. The technique was developed by Polish physicist Georges Nomarski in 1952. DIC works by separating a polarized light source into two orthogonally polarized mutually coherent parts which are spatially displaced (sheared) at the sample plane, and recombined before observation. The interference of the two parts at recombination is sensitive to their optical path difference (i.e. the product ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal-to-noise Ratio
Signal-to-noise ratio (SNR or S/N) is a measure used in science and engineering that compares the level of a desired signal to the level of background noise. SNR is defined as the ratio of signal power to the noise power, often expressed in decibels. A ratio higher than 1:1 (greater than 0 dB) indicates more signal than noise. SNR, bandwidth, and channel capacity of a communication channel are connected by the Shannon–Hartley theorem. Definition Signal-to-noise ratio is defined as the ratio of the power of a signal (meaningful input) to the power of background noise (meaningless or unwanted input): : \mathrm = \frac, where is average power. Both signal and noise power must be measured at the same or equivalent points in a system, and within the same system bandwidth. Depending on whether the signal is a constant () or a random variable (), the signal-to-noise ratio for random noise becomes: : \mathrm = \frac where E refers to the expected value, i.e. in this case ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantum Limit
A quantum limit in physics is a limit on measurement accuracy at quantum scales. Depending on the context, the limit may be absolute (such as the Heisenberg limit), or it may only apply when the experiment is conducted with naturally occurring quantum states (e.g. the standard quantum limit in interferometry) and can be circumvented with advanced state preparation and measurement schemes. The usage of the term standard quantum limit or SQL is, however, broader than just interferometry. In principle, any linear measurement of a quantum mechanical observable of a system under study that does not commute with itself at different times leads to such limits. In short, it is the Heisenberg uncertainty principle that is the cause. A more detailed explanation would be that any measurement in quantum mechanics involves at least two parties, an Object and a Meter. The former is the system whose observable, say \hat x, we want to measure. The latter is the system we couple to the Object in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
